Search Results (7,738)

The optimal reconfiguration of electrical distribution feeders is a fundamental strategy for reducing active power losses and improving voltage profiles, yet it remains a challenging mixed-integer nonlinear programming (MINLP) problem due to the combinatorial explosion of radial topologies and the nonlinearities introduced by power flow equations. This paper proposes a novel master–slave methodology that integrates a Chu and Beasley genetic algorithm (CBGA) with a minimum spanning tree (MST)-based repair mechanism to address these challenges. In the master stage, the CBGA explores the binary space of switching decisions via steady-state population management, duplicate elimination, and stagnation restart policies. A key contribution lies in the MST-based repair procedure, which ensures that every individual generated by crossover and mutation is projected onto a feasible radial and connected configuration, effectively confining the search to the constrained solution space without recourse to penalty functions. A systematic weight-design rule preserves the Hamming distance between infeasible offspring and repaired solutions, minimizing the distortion of genetic information. The slave stage evaluates each candidate topology using a successive approximations power flow solver, assessing electrical feasibility and computing active power losses. The proposed methodology is validated on multiple test feeders, ranging from small 9- and 24-bus networks to large-scale benchmarks including 33-, 69-, 84-, 136-, and 415-bus systems. A comparison against the deterministic sequential switch opening method (SSOM) and a specialized tabu search demonstrates that the CBGA-MST consistently matches the best-known optima in the literature, achieving loss reductions of up to 9.63% compared to SSOM on the 415-bus system. A statistical analysis over 100 independent runs confirms the algorithm’s robustness, with zero standard deviation for networks of up to 69 buses and a standard deviation of only 2.99 kW (0.51%) for the 415-bus system. The findings confirm that the proposed approach offers superior scalability, robustness, and solution quality, positioning it as a practical and effective tool for distribution system operators seeking to enhance network efficiency under peak load conditions. Full article

Background/Objectives: Arsenic (ARS) exposure is a major cause of kidney injury, driven by oxidative stress, inflammation, fibrosis, and apoptosis. This study evaluated the renoprotective effects of morin (MOR) and morin-loaded PLGA nanoparticles (MOR–PGNPs) against ARS-induced nephrotoxicity in rats. Methods: Sixty male Sprague Dawley rats were randomly allocated into six groups (n = 10 per group). The control group received corn oil. The MOR group received MOR (100 mg/kg), and the MOR–PGNPs group received the same dose of MOR encapsulated in PLGA nanoparticles. ARS was administered at 10 mg/kg for 14 days. Co-treated groups received ARS together with either MOR or MOR–PGNPs, with a 28 min interval between administrations. Renal function markers (serum urea, creatinine, uric acid, renal KIM-1), oxidative stress and antioxidant parameters (Nrf2/HO-1, CAT, SOD, GPx, ROS, MDA), inflammatory mediators (TLR4/NF-κB, TNF-α, IL-6, IL-1β), fibrotic markers (TGF-β1, fibronectin), and apoptotic proteins (caspase-3, caspase-8, Bax, Bcl-2) were assessed, alongside histopathological and ultrastructural evaluations. Results: ARS exposure significantly impaired renal function, increased KIM-1, suppressed Nrf2/HO-1 signaling, reduced antioxidant enzyme activities, and elevated ROS and MDA levels. It also activated TLR4/NF-κB signaling, upregulated pro-inflammatory cytokines and fibrotic markers, and increased pro-apoptotic proteins while downregulating Bcl-2. MOR co-treatment partially ameliorated these alterations. MOR–PGNPs produced potentially enhanced protection, restoring kidney function markers, enhancing antioxidant defenses, and markedly attenuating inflammation, fibrosis, and apoptosis. Histopathological and ultrastructural analyses confirmed preservation of glomerular and tubular architecture, mitochondrial integrity, and minimal cytoplasmic vacuolization in the MOR–PGNPs group. Conclusions: MOR–PGNPs at 100 mg/kg effectively mitigated ARS-induced renal damage through antioxidant, anti-inflammatory, antifibrotic, and anti-apoptotic mechanisms, supporting PLGA-based morin nanoparticles as a promising and safe renoprotective strategy. Full article

The COVID-19 pandemic exposed vulnerabilities in global blood supply systems and accelerated the adoption of patient blood management (PBM) strategies aimed at optimizing transfusion practices in surgical care. Perioperative anemia is a key contributor to adverse outcomes and is frequently treated with allogeneic blood transfusion (ABT), which carries infectious and immunologic risks. Iron deficiency remains the most common and potentially correctable cause of perioperative anemia. This narrative review examines various approaches to perioperative anemia, strategies to minimize reliance on ABT, and alternatives within the PBM paradigm. Evidence supports the use of iron therapy, erythropoiesis-stimulating agents, antifibrinolytic strategies, and blood conservation techniques to reduce transfusion requirements and improve clinical outcomes. Lessons from the COVID-19 pandemic highlight PBM as a framework to enhance transfusion safety and sustainability. Broader implementation of PBM may improve patient outcomes, reduce unnecessary transfusions, and preserve scarce blood resources. Full article

The search for extraterrestrial life has traditionally focused on environments where liquid H₂O is stable over long timescales, such as subsurface aquifers, hydrothermal systems, or ice-rich deposits. However, many planetary bodies are characterized by active cycles of particulate transport involving either mineral dust or atmospheric aerosols. In planetary science, these are commonly distinguished as refractory particles (non-volatile mineral dust) and volatile or mixed aerosol particles, including condensates such as ices, organics, or acidic droplets. Here, we propose the concept of planetary aerobiomes, defined as distributed particle-associated microbial persistence and dispersal systems in extraterrestrial environments. In this framework, refractory mineral particles may act as mobile particle-associated microenvironments that could support microbial survival and dispersal, while in some cases also providing partial physical shielding from environmental stressors. Drawing on observations from terrestrial dust-associated microbiomes and mineral–microbe interactions, particle-associated systems may represent previously overlooked ecological substrates in planetary environments. Rather than replacing models centred on environments with persistent liquid H₂O, this perspective expands them by considering particle-associated microenvironments as transient but potentially relevant biosignature-preservation niches in arid, dust-dominated worlds such as Mars, as well as in aerosol-rich environments including Titan, Venus, and icy moons. We further discuss the implications for life-detection strategies, highlighting atmospheric particles as potential reservoirs of biosignatures, and consider their relevance for applied microbiology, including in situ resource utilization (ISRU) and bioregenerative life-support systems (BLSS). Beyond astrobiological implications, understanding microbial persistence within particle-associated extreme environments may provide useful models for applied microbiology, including stress-resilient microbial engineering, biomining, contamination control, and bioregenerative technologies for space exploration. Full article

Retrofitting existing residential buildings is a critical strategy for achieving urban decarbonization while addressing public health disparities, particularly in communities disproportionately affected by environmental and socioeconomic stressors. This study presents a scalable urban building energy modeling framework that integrates physics-based simulations with machine learning to evaluate and prioritize health-driven retrofit strategies across residential building stocks. Synthetic datasets were generated through parametric simulations of representative building archetypes and retrofit scenarios, capturing variations in envelope performance, HVAC systems, infiltration rates, and ventilation strategies. Machine learning models were trained as surrogate predictors of building energy performance, enabling the rapid evaluation of retrofit impacts. A range of algorithms—including decision trees, random decision forests, gradient-boosting machines, support vector machines, k-nearest neighbors, and artificial neural networks—were evaluated. An artificial neural network implemented as a multilayer perceptron was selected for further analysis due to its strong predictive performance (R² = 0.94) and ability to capture complex nonlinear relationships among retrofit variables. The final model used the Port optimization algorithm for stable convergence and improved generalization. The framework is applied to Seattle’s Duwamish Valley, a community experiencing disproportionate environmental and health burdens, and is generalizable and transferable to other cities with comparable residential building stocks across a range of climatic and environmental contexts. The results highlight retrofit priorities—particularly infiltration reduction, HVAC upgrades, and improved envelope performance—that deliver co-benefits for energy efficiency, indoor environmental quality, and occupant health. The results demonstrate that machine learning-enhanced physics-based UBEM can significantly accelerate retrofit evaluation while preserving the interpretability of simulation-based approaches. The proposed framework provides a scalable approach for identifying health-informed retrofit pathways that support equitable urban decarbonization. Full article

Preservation of dentition remains the primary goal of equine dentistry; however, cheek tooth extraction is required in cases of severe dental pathology. Following tooth extraction, management of the post-extraction alveolus remains a significant clinical challenge due to its large size and susceptibility to contamination with feed material and bacteria. To mitigate these risks, alveolar plugs are commonly used to protect the alveolus, stabilize the blood clot, and support granulation tissue formation. This review summarizes the current case reports and research articles regarding the use of alveolar plugs following equine cheek tooth extraction, with a focus on packing materials, post-extraction management strategies, complications, and clinical outcomes. Reported packing materials include polymethyl methacrylate (PMMA), plaster of Paris (PoP), dental wax, gauze swabs, and polyvinyl siloxane (PVS). Each material has unique advantages and disadvantages, which are summarized in this review. The choice of plug material and its management protocol should be individualized for each case, as it depends on alveolar depth, tooth location, extraction method, and the presence of complications. Although standardized protocols for equine alveolar plug management have not yet been established, it may be suggested that any of the currently described packing materials can be used following routine tooth extractions. For marginally positioned teeth, gauze swab plugs may be more favorable, although they may not be the optimal choice in older horses. Regardless of whether the extraction is routine or complicated, alveolar inspection at 7–14-day intervals may be recommended. However, specific recommendations regarding alveolar inspection intervals and detailed management strategies require further research. Full article

The present work investigates the chemical composition of black cumin (Nigella sativa L.) cake obtained as a by-product of cold-pressed oil extraction. The aim of the study is to assess its potential for further utilization and secondary applications. By applying a combination of analytical techniques, including chemical analysis, Soxhlet extraction, ICP-OES, ICP-MS, FTIR, and SEM-EDS, the material was characterized as a rich organic matrix with a significant residual fat content (approximately 20%), proteins, and essential mineral elements such as K, Ca, Fe, Cu, Zn, and P, while containing low levels of toxic elements. Since cold pressing preserves residual bioactive compounds, and considering the high content of essential elements, black cumin cake represents a promising ingredient for food supplements. In addition, its porous surface structure observed by SEM-EDS, together with the functional groups identified by FTIR analysis, suggests potential sorption properties. These findings position black cumin cake as a promising resource within the framework of sustainable agro-industrial waste valorization strategies. Full article

Background/Objectives: Mild traumatic brain injury (mTBI) is common and may result in persistent cognitive and affective disturbances driven, at least in part, by delayed secondary injury mechanisms, including oxidative stress, neuroinflammation, apoptosis-related signaling, and impaired neuroplasticity. Pharmacological strategies targeting these interconnected processes remain limited. The present study investigated leucovorin, also known as folinic acid, a clinically approved reduced folate, as a potential repurposing candidate in an experimental model of mTBI. Methods: Male Wistar rats were subjected to mild diffuse brain injury using a modified weight-drop model and received a single intraperitoneal dose of leucovorin (20 mg/kg). Behavioral performance was evaluated using the open field, elevated plus maze, forced swim, and novel object recognition tests. Oxidative stress markers, including total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI), as well as inflammatory mediators tumor necrosis factor-α (TNF-α) and cyclooxygenase-2 (COX-2), caspase-3, brain-derived neurotrophic factor (BDNF), and acetylcholinesterase (AChE), were measured in hippocampal tissue and plasma. Histopathological and immunohistochemical evaluations were also performed in cortical and hippocampal regions. Results: Experimental mTBI was associated with anxiety-like and depressive-like behaviors and impaired recognition memory, whereas basal locomotor activity was not significantly altered. Trauma was also associated with increased oxidative stress, elevated inflammatory and apoptosis-related markers, reduced BDNF levels, altered AChE activity, and histopathological abnormalities. Compared with untreated mTBI animals, leucovorin-treated animals showed attenuation of biochemical and tissue alterations, accompanied by improved behavioral outcomes. Immunohistochemical findings were consistent with reduced inflammatory labeling and relative preservation of tissue architecture following leucovorin treatment. Conclusions: Leucovorin attenuated behavioral, biochemical, histopathological, and immunohistochemical alterations associated with experimental mTBI. These findings suggest that leucovorin may have neuroprotective potential in this setting; however, further studies are needed to clarify the underlying mechanisms, optimal treatment paradigms, and translational relevance. Full article

Wildfires are increasing in frequency and severity across Mediterranean ecosystems. However, the immediate soil biogeochemical responses that determine shortly post-fire resilience remain poorly understood. This study assessed how contrasting fire severity levels influence soil physicochemical, nutrient, and biochemical properties in ecologically relevant vegetation microsites—beneath Quercus ilex L. canopy, Stipa tenacissima L. tussock, and open interspaces—in a Mediterranean holm oak woodland in central Spain. Soils were sampled early after a wildfire and analyzed for organic matter, nutrient pools, water repellency, microbial respiration, nitrogen mineralization, and enzyme activities. Fire severity was the dominant driver of immediate post-fire soil responses. High-severity fire reduced soil organic matter, cation exchange capacity, total C and N, nitrate, microbial respiration, and all measured enzyme activities, with the most pronounced losses occurring beneath Q. ilex canopy. In contrast, ammonium, labile phosphorus, pH and soil water repellency increased under high severity, mainly in this microsite. Low-severity fire generally preserved biological functioning, with values comparable to unburned soils. Microsite identity modulated the magnitude of fire effects, with soils beneath Q. ilex cover microsite showing the greatest sensitivity, and open interspaces the least. The microsite × severity interaction detected for key nutrients and biochemical variables suggests that high-severity fire might destroy the microsite-specific fertility islands that constitute the functional core of Mediterranean woodland soils. These findings should be considered in management strategies prioritizing their monitoring and protection. Full article

Urban green spaces (UGSs) are increasingly recognised as critical infrastructure for mitigating climate extremes and promoting public health; indeed, the microclimatic mechanisms through which vegetation structure translates into measurable improvements in human comfort at the neighbourhood scale are of significant interest, particularly in the context of new urban developments. This study examines the cooling effects of an urban redevelopment project in the Marconi district of Imola, Italy, using ENVI-met (Version 6.0.0, ENVI-met GmbH, Essen, Germany) simulations to compare ex ante (current) and ex post (planned) scenarios under extreme heat conditions. Physiological Equivalent Temperature (PET) was computed at the pedestrian level for both standard adult and elderly models to assess spatial patterns of thermal comfort. The results demonstrate that tree canopies are the primary determinant of local cooling, with newly planted trees reducing PET by up to 3.5 °C at the core of the regenerated block and by 1–2 °C along adjacent pavements, while grass and low vegetation provided negligible mitigation. However, new buildings generated localised warming bands of 0.5–2 °C along façades, revealing a trade-off between densification and outdoor liveability. Elderly populations experienced slightly stronger thermal stress near buildings, highlighting spatial concentrations of vulnerability. These findings reinforce the need to prioritise tree planting and canopy management as core climate adaptation strategies, while simultaneously addressing near-building heat accumulation through integrated design approaches such as façade greening and ventilation preservation. The study demonstrates the value of spatially explicit microclimate simulation for evidence-based urban planning, contributing to the development of sustainable and liveable urban environments. Full article

Humankind is facing the enormous challenge of ensuring a sustainable future for new generations. A key guide to addressing this challenge is the Sustainable Development Goals (SDGs), which aim to promote economic and social development and environmental preservation. Despite the good intentions embedded in the SDGs, current performance worldwide remains below expectations. To be effective, the progress on the SDGs depends on the creation of new scientific knowledge. In this context, universities and research institutes should play a fundamental role in generating new scientific knowledge. Although recent models have been developed to assess universities’ knowledge creation to advance the SDGs, it remains necessary to develop new models that can more effectively evaluate and detail this capability. The goal of this article is to introduce a three-level framework for identifying SDG science at the country level across universities and research institutes. This model is validated through a documentary study based on SciVal-Elsevier data, on Brazilian universities, and a research institute in the context of SDG 2 research—zero hunger—between 2015 and 2024. As the main results, the framework provides three levels of knowledge mapping based on subject areas, knowledge categories, and cluster names, whereas the first and the last are used in the Scopus database, and the third is proposed in this study. As a result, this framework consists of a practical instrument for the mapping of the effective issues addressed in each SDG, and for comparing the effective content of SDG science between research institutions. As the main contribution, this article introduces a practical instrument for the assessment of the contribution of universities and research institutes in SDG science. Theoretically, this framework provides a practical process for rapidly identifying the current SDG science performance in research institutions at the country level. For practical purposes, this study can be used by universities, research institutes, and policymakers to understand the current state of SDG science in a country or region and to develop new research programmes and strategies for SDG science and innovation. Full article

Porous hydrogels are critical for tissue engineering and regenerative medicine, as they mimic the native extracellular matrix to support cell infiltration and mass transport. A common strategy for engineering pore structures involves the incorporation and subsequent removal of sacrificial porogen templates (e.g., crystals or microspheres). Although this approach offers excellent control over pore architecture, it often suffers from complex procedures and biosafety concerns arising from incomplete template removal. In this work, we present a simple, biocompatible, and versatile templating approach. By systematically investigating the coacervation parameters, we produced gelatin microspheres (GSs) with tunable diameters from 7 µm to 300 µm via a green, instrument-free, and scalable process. Using GSs of 20–160 µm as porogens, we obtained alginate hydrogels with adjustable viscoelasticity, stiffness, and pore sizes. We then validated two cell-loading strategies for bulk porous alginate hydrogels using immortalized human T (Jurkat) cells: (i) post-seeding into pre-formed pores supported high-density, long-term, and organized cell aggregates with > 90% viability; (ii) in situ encapsulation (prior to pore formation) yielded > 80% viability and preserved the cluster-forming growth characteristics of Jurkat cells. Moreover, composites of smaller GSs (7–20 µm) with alginate could be syringe-extruded into stable, sub-millimeter porous filaments, demonstrating the potential for 3D printing. Collectively, this work provides a promising platform for three-dimensional culture of immune cells. Full article

This paper examines the impact of the 1923 Turkish–Greek Population Exchange on the urban and architectural heritage of Tirilye, a historic coastal settlement in Bursa, Türkiye. The study addresses how migration-related transformations shaped both the tangible and intangible dimensions of heritage, focusing particularly on traditional houses and their adaptive reuse strategies. The research aims to identify patterns of continuity and transformation in residential architecture and to interpret population exchange heritage as a multi-layered cultural process. The study adopts a qualitative multi-method approach combining literature review, archival research, field surveys, architectural and typological analyses, and oral history interviews. The monuments and twenty-eight traditional houses were comparatively analysed at urban and building scales in terms of plan organisation, façade typology, construction techniques, and functional transformation. The findings demonstrate that Tirilye largely preserved its historic urban fabric despite demographic rupture. Traditional houses retained many original spatial and architectural characteristics while adapting to new social and economic conditions. The study reveals a hybrid architectural nature combining the effects of various living traditions and highlights the continuity of production-related spaces associated with olive cultivation and sericulture. The paper proposes understanding population exchange heritage as a dynamic process shaped by continuity, adaptation, reuse, and collective memory. Full article

The persistence of petrochemical plastics necessitates high-performance and recyclable alternatives, yet balancing mechanical robustness with component-level closed-loop recovery remains challenging for biomass-based plastic-replacement films. Here, a high-performance, thermo-malleable, and closed-loop recyclable composite film is constructed by integrating a highly crystalline enzyme-treated mulberry paper (Enzyme-MP) fiber network with an in situ formed polyimine (PI) vitrimer network via capillary-assisted infiltration. This process induces densification and extensive interfacial hydrogen bonding, forming a confined interpenetrating architecture that enhances stress transfer and restricts chain mobility. As a result, the composite film achieves a tensile strength of 70.3 MPa and a Young’s modulus of 2.37 GPa, together with excellent thermomechanical stability over a broad temperature range. The dynamic imine exchange enables thermo-malleability, allowing seamless self-welding and thickness-scalable lamination at 120 °C. The dense structure also acts as an effective barrier, reducing water uptake to 14.3% and providing resistance to various organic solvents. Furthermore, full-component closed-loop recycling is realized via room-temperature transimination, enabling selective depolymerization of the matrix while preserving the crystalline cellulose fiber network. This work demonstrates a viable strategy to integrate high-strength film performance, processability, and chemical recyclability in biomass-based composite films, while providing a basis for future cradle-to-cradle material circulation in recyclable plastic-replacement films. Full article

Brain aging is a complex biological process characterised by progressive neuronal and synaptic decline, in which disruption of mitochondrial quality control plays a central role. This system encompasses multiple synergistic components, including mitochondrial biogenesis, dynamic equilibrium, autophagic clearance, and energy metabolism. Aging induces dysfunction across these processes, precipitating mitochondrial fragmentation, functional decline, and energy crises, ultimately driving cognitive deterioration. Exercise is a promising non-pharmacological intervention for preserving brain health during aging, and its benefits may be mediated, at least in part, through modulation of mitochondrial quality control. Specifically, exercise has been shown to activate key signaling pathways such as AMPK/SIRT1/PGC-1α, thereby promoting mitochondrial biogenesis and metabolic adaptation. It may also regulate mitochondrial dynamics and mitophagy via pathways including cAMP/PKA/Drp1 and AMPK/mTOR. In addition, emerging evidence indicates that exercise may influence brain mitochondrial function through activity-dependent regulation of mitochondrial gene expression and systemic signaling factors. Furthermore, this review discusses potential differences between exercise modalities and highlights future directions for personalised intervention strategies, providing a theoretical basis for the application of exercise in delaying brain aging and preventing neurodegenerative diseases. Full article