Search Results (9,989)

With the rapid evolution of technology and the continuous deepening of digital transformation in education, personalized and adaptive learning have emerged as inevitable trends in the educational landscape. This study focuses on a Computerized Adaptive Learning System Based on Cognitive Diagnosis (CAL-CDS)—an integrated platform that incorporates multiple technologies for assessment and learning. The study is organized around two dimensions: (1) constructing a foundational cognitive diagnostic assessment framework, and (2) investigating the operational mechanisms of the cognitive diagnosis-based computerized adaptive system. It comprehensively incorporates core components including cognitive modeling, Q-matrix generation, and diagnostic test development. On this basis, this study dissects the system’s operational logic from four aspects: the adaptive testing system, diagnostic system, recommendation system, and empirical case studies. This study effectively addresses two core questions: how to construct a cognitive diagnostic assessment framework that alignes with China’s mathematics knowledge structure, and how to facilitate personalized student learning via cognitive diagnosis. Overall, this study offers a systematic solution for developing mathematics-specific cognitive diagnosis-driven adaptive learning systems. Full article

The rapid proliferation of Chat Generative Pre-trained Transformer (ChatGPT) marks a pivotal moment in artificial intelligence, eliciting responses from academic shock to industrial awe. As these technologies advance from passive tools toward proactive, agentic systems, their transformative potential and inherent risks are magnified globally. This paper presents a comprehensive, critical review of ChatGPT’s impact across five key domains: natural language understanding (NLU), content generation, knowledge discovery, education, and engineering. While ChatGPT demonstrates profound capabilities, significant challenges remain in factual accuracy, bias, and the inherent opacity of its reasoning—a core issue termed the “Black Box Conundrum”. To analyze these evolving dynamics and the implications of this shift toward autonomous agency, this review introduces a series of conceptual frameworks, each specifically designed to illuminate the complex interactions and trade-offs within these domains: the “Specialization vs. Generalization” tension in NLU; the “Quality–Scalability–Ethics Trilemma” in content creation; the “Pedagogical Adaptation Imperative” in education; and the emergence of “Human–LLM Cognitive Symbiosis” in engineering. The analysis reveals an urgent need for proactive adaptation across sectors. Educational paradigms must shift to cultivate higher-order cognitive skills, while professional practices (including practices within education sector) must evolve to treat AI as a cognitive partner, leveraging techniques like Retrieval-Augmented Generation (RAG) and sophisticated prompt engineering. Ultimately, this paper argues for an overarching “Ethical–Technical Co-evolution Imperative”, charting a forward-looking research agenda that intertwines technological innovation with vigorous ethical and methodological standards to ensure responsible AI development and integration. Ultimately, the analysis reveals that the challenges of factual accuracy, bias, and opacity are interconnected and acutely magnified by the emergence of agentic systems, demanding a unified, proactive approach to adaptation across all sectors. Full article

Organophosphorus pesticides (OPs) pose significant environmental and health risks due to their widespread use and toxicity, primarily by inhibiting acetylcholinesterase. Traditional detection methods are often slow and costly, highlighting the urgent need for advanced, sensitive, and accessible technologies. This study developed a highly sensitive electrochemical cholinesterase-inhibiting biosensor for OP pesticides, utilizing Ti₃C₂T_x MXene Quantum Dots (MQDs), which was synthesized via a hydrothermal method. The biosensor’s performance was characterized using electrochemical impedance spectroscopy, differential pulse voltammetry (DPV), and cyclic voltammetry. DPV proved to be the optimal technique, exhibiting an ultralow detection limit of 1 × 10⁻¹⁷ M and a wide linear range (10⁻¹⁴–10⁻⁸ M) for chlorpyrifos (a model OP) with an estimated inhibition constant of 62 nM. The biosensor demonstrated high selectivity for OPs (chlorpyrifos, acephate, glyphosate) over a non-target pyrethroid (permethrin), confirmed by distinct electrochemical signatures and compared to in vitro cholinergic activity assays in bean beetle homogenates. The enhanced performance is attributed to the high surface-to-volume ratio, quantum confinement effects, and superior conductivity of the MQDs, as well as the robust enzyme immobilization facilitated by glutaraldehyde cross-linking and a chitosan matrix. This work presents a promising platform for rapid, sensitive, and selective detection of OP pesticides, with potential applications in environmental monitoring and public health protection. Full article

A highly efficient method was successfully applied for the first time to the functionalization of well-defined chlorinated silsesquioxanes with a range of thiols. Thiolation was rapid (2 to 4 h), quantitative, with complete conversion of the reactants and full chemoselectivity, and proceeded under mild conditions (room temperature). This “click chemistry” approach facilitated the preparation of nine novel compounds, with good to excellent isolated yields (64–92%). The structures and purities of these compounds were comprehensively confirmed using multiple analytical techniques, including ¹H, ¹³C, and ²⁹Si NMR spectroscopy, elemental analysis, and mass spectrometry. Thermogravimetric analysis (TGA) further demonstrated that the synthesized compounds exhibited excellent thermal stability. These characteristics suggest their potential for applications in various domains of science, technology, and medicine. Full article

Monkeypox (Mpox), a re-emerging zoonotic disease, has garnered global attention due to its evolving epidemiology, diverse clinical manifestations, and significant public health impact. The rapid international spread of the Mpox prompted the World Health Organization to designate the outbreak as a Public Health Emergency of International Concern. Accurate and timely diagnosis is hindered by its critical resemblance to other orthopoxviruses and viral exanthems, underscoring the need for improved diagnostic tools. Point-of-care diagnostic innovations, including CRISPR-based and smartphone-integrated technologies, have revolutionized outbreak management, offering rapid and accurate detection critical for containment and treatment. The effective control of Mpox outbreak underscores the necessity of strengthened global surveillance, equitable healthcare access, rapid diagnostics, the prompt isolation of infected individuals, and the implantation of ring vaccination strategies. The integration of a “One Health” framework that links human, animal, and environmental health is vital for sustained preparedness. Advances in vaccine development, including novel bionic self-adjuvating vaccines and platforms utilizing DNA, mRNA, and viral vectors, highlight promising prevention efforts. However, issues such as vaccine hesitancy, limited immunization coverage and accessibility in resource-constrained regions remain significant barriers. Therapeutic interventions like tecovirimat and the JYNNEOS vaccine demonstrate efficacy but face challenges in scalability and deployment. To address these multifaceted challenges, this review delves into the molecular insights, clinical features, epidemiological trends, and diagnostic challenges posed by Mpox. This review further highlights the critical need for robust scientific evidence and sustained research to inform effective, evidence-based responses, and long-term management strategies for Mpox outbreaks. Full article

With the rapid evolution of 5G wireless communications, millimeter-wave (mmWave) technology has become a crucial enabler for high-speed, low-latency, and large-scale connectivity. As the critical interface for signal transmission, mmWave antennas directly affect system performance, reliability, and application scope. This paper reviews the current state of mmWave antenna technologies in 5G systems, focusing on antenna types, design considerations, and integration strategies. We discuss how the multiple-input multiple-output (MIMO) architectures and advanced beamforming techniques enhance system capacity and link robustness. State-of-the-art integration methods, such as antenna-in-package (AiP) and chip-level integration, are examined for their importance in achieving compact and high-performance mmWave systems. Material selection and fabrication technologies—including low-loss substrates like polytetrafluoroethylene (PTFE), hydrocarbon-based materials, liquid crystal polymer (LCP), and microwave dielectric ceramics, as well as emerging processes such as low-temperature co-fired ceramics (LTCC), 3D printing, and micro-electro-mechanical systems (MEMS)—are also analyzed. Key challenges include propagation path limitations, power consumption and thermal management in highly integrated systems, cost–performance trade-offs for mass production, and interoperability standardization across vendors. Finally, we outline future research directions, including intelligent beam management, reconfigurable antennas, AI-driven designs, and hybrid mmWave–sub-6 GHz systems, highlighting the vital role of mmWave antennas in shaping next-generation wireless networks. Full article

With the rapid advances of the electronics industry, a large amount of acidic etching waste solutions (AEWS) for etching Printed Circuit Board (PCB) are generated, which require complete remediation and sustainable recycling to avoid environmental pollution and wasting of resources. Herein, the novel purification technology for the acidic copper-containing etching waste solution was exploited via integrated alkali gradient pH control (3.0, 3.2, and 3.5). At pH 3.0, the system demonstrated selective metal removal with 94.02% efficiency for Fe and 82.60% for Mn. Elevating the pH to 3.2 enabled effective elimination of Zn (59.32%), Cr (59.46%), and Al (33.24%), while maintaining minimal copper loss (8.16%). Further pH adjustment to 3.5 achieved enhanced removal efficiencies of 97.86% (Fe), 91.30% (Mn), 59.38% (Zn), 62.10% (Cr), 21.66% (Ca), 34.05% (Al), and 26.66% (Co), with copper retention remaining high at 70.83% (29.17% loss). Furthermore, using the purified AEWS (pH 3.2) as precursor, high-purity nano-CuO was successfully synthesized through a Cu₂(OH)₃Cl conversion-calcination process, exhibiting 99.20% CuO purity with 0.0012% chlorine content and <0.1% metallic impurities. The development and application of the purification technology for AEWS containing copper, along with the production methodology for high-purity CuO, were significant to the fields of electronic information industry, environmental engineering, green industry and sustainable development of the ecological environment. Full article

Over a decade ago, WHO introduced the ASSURED (Affordable, Sensitive, Specific, User-friendly, Rapid and Robust, Equipment-free, and Deliverable to end-users) criteria to guide diagnostic assay development. Today, lateral flow assays (LFAs) best meet these standards, evolving from simple rapid tests to advanced diagnostics integrating AI and nanotechnology for precise, quantitative results. Notably, nanoparticle-enhanced LFAs have achieved limits of detection (LOD) as low as 0.01 pg/mL (a 100-fold improvement over conventional methods), while AI algorithms have reduced interpretation errors by 40% in low-contrast conditions. The COVID-19 pandemic underscored the societal impact of LFAs, with over 3 billion antigen tests deployed globally, demonstrating 98% specificity in real-world surveillance. Beyond infectious diseases, LFAs are revolutionizing cancer screening through liquid biopsy, achieving a 92% concordance rate with gold-standard assays, food safety and environmental monitoring. Despite these advancements, challenges remain in scalability, reproducibility, sustainable manufacturing, and how to enhance the sensitivities and lower the LOD. However, innovations in biodegradable materials, roll-to-roll printing, CRISPR-integrated multiplexing, and efficient functionalization methods like photochemical immobilization technique offer promising solutions, with projected further cost reductions and scalability. This review highlights the technological evolution, diverse applications, and future trajectories of LFAs, highlighting their critical role in democratizing diagnostics. Full article

Recent progress in microfluidic technologies has led to the development of compact and highly efficient electrochemical platforms, including lab-on-a-chip (LoC) systems, that integrate multiple testing functions into a single, portable device. Combined with smartphone-based electrochemical devices, these systems enable rapid and accurate on-site detection of food contaminants, including pesticides, heavy metals, pathogens, and chemical additives at farms, markets, and processing facilities, significantly reducing the need for traditional laboratories. Smartphones improve the performance of these platforms by providing computational power, wireless connectivity, and high-resolution imaging, making them ideal for in-field food safety testing with minimal sample and reagent requirements. At the core of these systems are electrochemical biosensors, which convert specific biochemical reactions into electrical signals, ensuring highly sensitive and selective detection. Advanced nanomaterials and integration with Internet of Things (IoT) technologies have further improved performance, delivering cost-effective, user-friendly food monitoring solutions that meet regulatory safety and quality standards. Analytical techniques such as voltammetry, amperometry, and impedance spectroscopy increase accuracy even in complex food samples. Moreover, low-cost engineering, artificial intelligence (AI), and nanotechnology enhance the sensitivity, affordability, and data analysis capabilities of smartphone-integrated electrochemical devices, facilitating their deployment for on-site monitoring of food and agricultural contaminants. This review explains how these technologies address global food safety challenges through rapid, reliable, and portable detection, supporting food quality, sustainability, and public health. Full article

Ecosystem services are crucial for animals, plants, the planet, and human well-being. Decreasing biodiversity and environmental destruction of ecosystems will have severe consequences. Designing technologies that could support, enhance, or even replace ecosystem services is a complex task that the Manufactured Ecosystems Project team considers to be only achievable with transdisciplinarity, as it unlocks new directions for designing research and development systems. One of these directions in the project is bio-inspiration, learning from natural systems as the foundation for manufacturing ecosystem services. Using soil formation as a case study, text-mining of existing scientific literature reveals a critical gap: fewer than 1% of studies in biomimetics address soil formation technological replacement, despite the rapid global decline in natural soil formation processes. The team sketches scenarios of ecosystem collapse, identifying how bio-inspired solutions for equitable and sustainable innovation can contribute to climate adaptation. The short communication opens the discussion for collaboration and aims to initiate future research. Full article

Organ-on-a-chip (OoC) technology aims to replicate the functions of human organs and tissues. This study evaluates femtosecond laser micromachining (FLM) for producing PDMS membranes with controlled porosity as an alternative approach to conventional microfabrication for OoCs. Membranes of varying thicknesses were microdrilled, and the influence of laser parameters on microhole geometry was assessed, showing that pulse energy strongly affected hole diameter, whereas exposure time had a lesser impact. The heat-affected zone (HAZ) and taper angle, key indicators of microhole geometric quality, were also analyzed and found to be strongly dependent on membrane thickness. Prediction models were developed to guide parameter selection for future laser-based ablation processes. A numerical model that predicts plasma shielding effects provided further insight into the physics of PDMS laser ablation, revealing that higher pulse energies led to a marked increase in crater diameter. The fabricated membranes were integrated into an OoC device, onto which human mesenchymal stem cells were seeded. The results demonstrated strong cell adhesion, the rapid formation of a homogeneous monolayer, and no evidence of cytotoxicity. These findings confirm that FLM is a versatile and flexible technique for microdrilling PDMS membranes, enabling their effective integration into OoC. Full article

Metal additive manufacturing techniques have seen technological advancements in recent years, fueled by their ability to provide industrial use parts with excellent mechanical properties. Wire Arc Additive Manufacturing is a technology that is being widely used in critical industries, and much research is conducted in this field due to the multiple factors involved in the overall process. Within WAAM, gas metal arc welding stands out for its low cost, high production volume, high quality and capability for automation. In this study, a CNC router was retrofitted with a gas metal arc welding setup to facilitate precise metal printing. The flexibility in this process allows for rapid repairs on site without the need to replace the entire part. The literature predominantly focuses on the macro-mechanical properties of GMAW parts, and very few studies try to study the interaction and influence of different process parameters on the mechanical properties. Thus, this study focused on the GMAW WAAM of stainless-steel parts by studying the influence of the wire feed rate, arc voltage and strain rate on the UTS, yield strength, toughness and percentage elongation. ANOVA and interaction plots were analyzed to study the interaction between the input parameters on each output parameter. Results showed that printing stainless steel through the gas metal arc welding process with an arc voltage of 18.7 V and a wire feed rate of 6 m/min resulted in poor mechanical properties. The input parameter that influenced the mechanical properties the highest was the wire feed rate, followed by the arc voltage and strain rate. Printing with an arc voltage of 18.7 V and a wire feed rate of 5 m/min, tested at a crosshead speed of 1 mm/min, gave the best mechanical properties. Full article

The rapid evolution of the metaverse is driving the development of new digital design tools that integrate Computer-Aided Design (CAD) and Building Information Modeling (BIM) technologies. Core technologies such as Virtual Reality (VR), Augmented Reality (AR), and Mixed Reality (MR) are increasingly combined with BIM to enhance collaboration and innovation in design and construction workflows. However, current BIM–VR integration often remains limited to isolated tasks, lacking persistent, multi-user environments that support continuous project collaboration. This study proposes a BIM-based Virtual World (VW) framework that addresses these limitations by creating an immersive, real-time collaborative platform for the Architecture, Engineering, and Construction (AEC) industry. The system enables multi-user access to BIM data through avatars, supports direct interaction with 3D models and associated metadata, and maintains a persistent virtual environment that evolves alongside project development. Key functionalities include interactive design controls, real-time decision-making support, and integrated training capabilities. A prototype was developed using Unreal Engine and supporting technologies to validate the approach. The results demonstrate improved interdisciplinary collaboration, reduced information loss during design iteration, and enhanced stakeholder engagement. This research highlights the potential of BIM-based Virtual Worlds to transform AEC collaboration by fostering an open, scalable ecosystem that bridges immersive environments with data-driven design and construction processes. Full article

As a vital transition metal species, cobalt ions (Co²⁺) play a critical role in industrial and medical fields. However, uncontrolled release into ecosystems via industrial effluents presents significant environmental risks. To address this, a prism-coupled surface plasmon resonance (SPR) sensor chip was developed which enables simultaneous high sensitivity, wide detection range, and rapid detection of Co²⁺ under ultra-low detection limit conditions. By depositing a 50 nm Au film and AuNPs on a glass substrate, and integrating carboxyl-functionalized carbon quantum dots (CQDs), the chip achieved the detection range of 10⁻²⁰ mol/L to 10⁻⁴ mol/L, and the response time was reduced from 21 min to 11 min under optimal electric field conditions (1.2 V, 0.15 mol/L electrolyte concentration). The sensor exhibits high selectivity, repeatability, and stability. It can be integrated with optofluidic technology to enable high-throughput microfluidic analysis, thereby facilitating further advancements in related research. Full article

The increasing frequency of extreme weather events and rapid urbanization has exacerbated pluvial flood risks, underscoring the urgent need to strengthen the assessment of pluvial flood resilience in China’s southwestern mountainous regions. Kunming—a plateau basin city—was selected as a case study, and an urban pluvial flood resilience assessment system was developed based on the DPSIR model. The analytic hierarchy process (AHP), entropy method, and game theory-informed combination weighting were applied to determine indicator weights, while the extension cloud model was utilized to quantitatively assess resilience evolution from 2013 to 2022. The results reveal that: (1) Kunming’s pluvial flood resilience experienced a clear three-stage evolution—initial construction (Level II), resilience enhancement (Level III), and resilience reinforcement (Level IV)—reflecting a transition from rudimentary resilience to advanced adaptive capacity; (2) the ranking of primary indicator weights is as follows: Driving Forces > Pressure > State > Response > Impact, with Flood Disaster Risk (P6), Flood Disaster Early Warning Capability (R1), and Topographic and Geomorphological Characteristics (P7) identified as key influencing factors; (3) marked disparities exist across the five dimensions: the Driving Forces dimension demonstrates increasing economic support; the Pressure dimension reflects structural vulnerabilities and climate variability; the State and Impact dimensions advance incrementally through policy implementation; and the Response dimension has substantially improved due to smart city technologies, although persistent gaps in inter-agency emergency coordination remain. This research offers a scientific basis for enhancing pluvial flood resilience in southwestern mountainous cities. Full article