Search Results (1,025)

Exosomes (EXs) mediate intercellular communication in the tissue microenvironment. We previously demonstrated that endothelial progenitor cell-derived exosomes (EPC-EXs) from exercised mice protect neurons and cerebral endothelial cells from hypoxia- and hypertension- induced injury ex vivo, suggesting their therapeutic potential in hypertensive ischemic injury. Here, we investigated whether exercise-conditioned EPC-EXs (ET-EPC-EXs) confer protection against acute ischemic injury. Hypertensive transgenic mice were divided into donor and recipient groups. Donor mice underwent treadmill exercise to generate ET-EPC-EXs. Recipient mice was subjected to middle cerebral artery occlusion and received ET-EPC-EXs via tail vein injection (2 × 10⁸/100 μL saline) two hours after stroke onset. Cerebral blood flow (CBF) was assessed, and brains were collected on day two for histological and molecular analyses. Our data showed that ET-EPC-EXs were robustly taken up by cerebral cells, predominantly in the penumbra in the ipsilateral hemisphere. ET-EPC-EXs reduced cell death and microglia activation and restored tight-junction proteins. Moreover, ET-EPC-EX treatment preserved CBF and improved sensorimotor function on day two post-stroke. Mechanistically, ET-EPC-EXs suppressed p38 activation, accompanied by reduced matrix metalloproteinase-3 and cytochrome c levels in the ipsilateral brain. Collectively, these findings demonstrate that EPC-EXs from exercise mice improve sensorimotor functions and confer protection in hypertensive ischemic brain injury, likely through attenuation of neuroinflammation and preservation of vascular integrity via modulation of the p38 signaling. Full article

Background/Objectives: Joubert syndrome (JS) is a rare neurodevelopmental disorder characterized by cerebellar and brainstem malformations, resulting in a complex and heterogeneous motor phenotype. Despite increasing clinical recognition, functional assessment and physiotherapy strategies in this population remain insufficiently characterized. This study aimed to synthesize current rehabilitation evidence and to propose a conceptual framework for functional motor assessment in children with JS. Methods: A structured narrative review was conducted across PubMed, Scopus, Web of Science, EBSCOhost, the Cochrane Library, and PEDro databases, including studies published between 2000 and 2026. Eligible studies involved pediatric patients (0–18 years) with JS and reported physiotherapy or motor-related outcomes. Data were synthesized descriptively, and recurring functional domains were identified to inform the development of a conceptual framework. Results: Ten studies (eight case reports and two case series) were included. Rehabilitation approaches were heterogeneous and predominantly multidisciplinary, focusing on postural control, trunk stability, and motor milestone acquisition. Functional improvements were reported across studies; however, outcome measures were primarily based on generic pediatric tools such as GMFM-88 and WeeFIM. These tools did not fully capture the multidimensional nature of motor impairment, particularly in relation to regulatory and sensorimotor domains. Evidence also suggested that postural control and gross motor performance may not fully correspond, highlighting additional functional components such as axial control and thoracoabdominal organization. Given the absence of formal risk-of-bias assessment and the low methodological quality of included studies, all findings should be interpreted as exploratory. Conclusions: Current functional assessment in JS may not adequately reflect the interaction between regulatory processes, sensorimotor integration, and motor control. The proposed conceptual framework provides a multidimensional, hypothesis-generating perspective that may support clinical reasoning and physiotherapy planning. Further research is required to validate this framework and to develop more sensitive, syndrome-specific assessment tools. Full article

Background/Objectives: This systematic review synthesizes MRI evidence to characterize neuromorphological alterations in somatosensory and vestibular brain regions among adolescents with idiopathic scoliosis (AIS). Methods: This systematic review was conducted in accordance with the PRISMA 2020 guidelines. We systematically searched five databases from inception to January 2026 for case–control MRI studies comparing AIS patients (10–18 years) with healthy controls. Two reviewers independently screened studies, extracted data, and assessed the risk of bias using the Newcastle–Ottawa Scale. Results: Across 15 studies (1270 participants), AIS patients demonstrated consistent neuromorphological alterations: (1) lower cerebellar tonsil position (0.9–2.8 mm below baseline), with ectopia incidence correlating with curve severity; (2) cortical thickening in bilateral medial regions but thinning in left paracentral areas; (3) left-dominant white matter volume increases and impaired microstructure in the corpus callosum; and (4) left-sided vestibular morphological changes, including a more vertical semicircular canal. Conclusions: AIS is associated with consistent neuromorphological alterations in key somatosensory and vestibular regions, supporting a potential neuroanatomical basis for impaired sensorimotor integration in its pathogenesis. It should be noted that substantial heterogeneity among the included studies prevented a meta-analysis, and the cross-sectional design limits causal interpretations Registration: This systematic review was registered in PROSPERO (CRD42024577195). Full article

Human motor control has long been described within traditionally deterministic frameworks that emphasize consistency and error minimization. However, accumulating evidence across motor learning, coordination dynamics, and information theory suggests that variability and uncertainty are not merely sources of noise but fundamental resources for adaptive behavior. This review synthesizes theoretical, empirical, and methodological advances to propose an integrative probabilistic framework for motor control. Drawing on complex-systems theory, entropy-based analyses, and hierarchical coordination models, motor behavior is conceptualized as a self-organizing process that continuously balances stability and flexibility under uncertainty. Variability is reinterpreted as functionally regulated, supporting exploration, reorganization, and context-sensitive adaptation rather than reflecting control failure. To formalize this perspective, a Probabilistic Landscape Model is introduced, in which motor behaviors are represented as trajectories within a dynamic landscape of multiple attractors. Within this framework, entropy captures the structured organization of uncertainty, metastability enables rapid transitions between coordination states, and probabilistic stability characterizes the system’s capacity to maintain effective performance across changing constraints. Beyond synthesizing existing research, this review introduces the Probabilistic Landscape Model (PLM), a conceptual framework that integrates nonlinear coordination dynamics, entropy-based variability analysis, and probabilistic interpretations of motor behavior. By integrating insights from motor learning, sports performance, rehabilitation, and predictive processing, this review provides a unified account of adaptive motor control as an inherently probabilistic and self-organizing system. The proposed framework offers conceptual and practical implications for training design, rehabilitation strategies, and human–machine interaction in uncertain environments. Full article

Background: Spinal cord injury (SCI) is a severe pathological condition resulting in persistent motor and sensory impairments. The trace amine-associated receptor 5 (TAAR5) is a potential modulator of central nervous system functions; however, its role in CNS repair remains poorly understood. Methods: We comprehensively evaluated the effect of TAAR5 gene knockout on functional recovery following lateral spinal cord hemisection in TAAR5-KO and wild-type (WT) male mice. Sensorimotor recovery after SCI was assessed using the horizontal ladder, grasp, and hindlimb mobility tests. Exploratory and anxiety-like behaviors were evaluated using the open field and elevated plus maze tests before and 5 weeks after SCI. Results: TAAR5-KO mice exhibited accelerated recovery of sensorimotor functions, as assessed by joint mobility and grasping tests, compared to WT animals. In contrast, no significant intergroup differences were found in the Horizontal Regular Ladder test, likely due to the task complexity and an insufficient recovery period. Nevertheless, SCI induced elevated anxiety-like behavior regardless of genotype. Conclusions: These findings indicate that TAAR5 deficiency exerts a positive modulatory effect on the restoration of specific components of sensorimotor function after SCI. This effect may be mediated through the modulation of dopaminergic neurotransmission and inflammatory processes. The observed beneficial effect of TAAR5 knockout identifies this receptor as a promising target for developing novel therapeutic strategies aimed at improving functional outcomes following spinal cord injury. Full article

Background: Traditional functional mobility assessments often fail to detect subclinical postural decline in active aging populations. This study introduces the Head–Sternum Dissociation Index as a novel digital biomarker to identify latent sensorimotor deficits before macroscopic balance failure occurs. Methods: Ninety-four participants (Young, Middle-Aged Civil, Middle-Aged Dancers, and Older Adults) performed instrumented limits of stability tasks, specifically functional and lateral reach tests, utilizing a three-sensor inertial measurement unit configuration. Postural strategies were quantified via the Head–Sternum Dissociation Index and the peak ratio of corrective micro-movements, validating the sensor output against a gold-standard force platform. Results: A significant kinematic breakpoint in postural control was identified at age 55 (p < 0.001). However, Middle-Aged Civilians exhibited early kinematic divergence despite maintaining normal Timed Up and Go test performance. Receiver operating characteristic analysis revealed distinct, sex-specific physiological limits: aging males predominantly adopted a rigid “Stiffness” strategy (peak ratio ≤ 1.15, head–sternum dissociation threshold > 0.63°), while females utilized a broader, more permissive “Continuous” strategy (head–sternum dissociation threshold > 0.31°). Notably, recreational rhythmic training (dance) completely neutralized this age-related decay, with middle-aged dancers maintaining highly efficient, youthful stabilization profiles (Cohen’s d = 2.20). Conclusions: The Head–Sternum Dissociation Index, combined with relative corrective frequency, successfully phenotypes early sensorimotor erosion. These findings advocate for the integration of sex-specific kinematic screening into primary care, allowing clinicians to prescribe targeted interventions well before clinical fall risk manifests. Full article

Background/Objectives: Due to their positions, professional baseball catchers are at elevated risk of concussion, which can impair visual processing. There is a need for sensitive sensorimotor monitoring tools to track concussion-related neurophysiological changes more accurately. We investigated whether oculometrics can address this need. Methods: Four Major League Baseball catchers completed an oculometric assessment shortly after suffering a concussion (Time 1) and again after completing vision rehabilitation (Time 2). The assessment produces 10 z-scored measures, including a summary score. Results: Players’ Time 1 summary score tended to be typical of a normal healthy adult (Mean = 0.07 z-scored units). On average, players improved by 1.3 z-score units from their Time 1 summary score (SD = 1.07). Exploratory analyses revealed that sensorimotor recovery was driven by smooth pursuit latency, proportion of tracking comprising smooth pursuit, and the amplitude of catch-up saccades. Conclusions: Our analysis was based on a very small sample of concussion cases, each of which was unique. Despite this limitation, our data show how oculometrics can measure improvements in visual processing following a concussion among baseball players with exceptional perceptual-motor skills. Our data highlight the risk that brain injuries in high-performing individuals go undetected due to standard-of-care tools normed to behavior from healthy control populations; for these athletes, “normal” scores cannot be interpreted as neurologically “healthy”. Full article

Postural balance is a foundational component of human motor behavior, yet it remains conceptually ambiguous and methodologically heterogeneous across the clinical, educational, and sport sciences. This narrative review aims to provide an integrative framework that clarifies key concepts (postural control vs. postural balance), synthesizes the main sensorimotor and biomechanical mechanisms underpinning balance, and organizes current assessment approaches and functional implications across populations. Narrative literature synthesis was conducted to integrate evidence covering multisensory integration and sensory reweighting, central neural control (spinal, brainstem, cerebellar, and cortical contributions), neuromuscular and biomechanical strategies (e.g., ankle/hip/stepping), and cognitive influences (e.g., dual-task effects). We further summarize commonly used instrumental outcomes derived from force-platform center-of-pressure metrics and widely adopted clinical and functional balance tests, highlighting their typical applications and limitations across the lifespan including pediatric, general adults, older adults, and athletic populations. This review proposes a closed-loop, systems-based model in which postural balance is conceptualized as an emergent functional outcome arising from distributed postural control processes shaped by task, environmental, and individual constraints. In conclusion, integrating mechanistic understanding with population-specific assessment enhances interpretability and supports more precise, context-sensitive balance evaluation and intervention in both health and performance settings. Full article

Background/Objectives: This study investigates the relationship between Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP), neurophysiological markers assessed via Visual Evoked Potentials (VEPs), and functional capacity. Methods: A total of 190 participants, comprising 95 patients and 95 healthy controls, underwent specialized assessments of VEP latencies and amplitudes (P100 and N145), as well as dominant and non-dominant grip strength. Statistical analyses using independent-samples t-tests and linear regression revealed that patients exhibited significantly prolonged P100 and N145 latencies and reduced P100 amplitudes compared with controls, reflecting impaired neural conduction and heterogeneous fiber involvement. Results: Patients also demonstrated markedly reduced bilateral grip strength, confirming the disease’s impact on gross motor skills and sensorimotor integration. Although gender did not broadly differentiate clinical expression, patients receiving intravenous immunoglobulin (IVIg) therapy showed significant improvements in P100 latency and bilateral grip strength, compared with those not receiving treatment. Conclusions: These findings underscore the utility of VEPs and grip strength as reliable biomarkers for monitoring demyelination and functional status, suggesting that their combined evaluation can enhance clinical management and the assessment of therapeutic response in CIDP. Full article

Background/Objectives: Advanced childhood cerebral X-linked adrenoleukodystrophy (cALD) is traditionally regarded as an irreversible terminal phase of neurodegeneration driven by inflammatory demyelination and axonal loss. Experimental evidence indicates that endogenous bioelectrical fields regulate central nervous system organisation, raising the possibility that functional network collapse in cALD may be biologically modifiable, even in the presence of persistent structural damage. This study examined whether longitudinal modulation of endogenous bioelectrical network organisation is associated with sustained clinical and neurophysiological stabilisation in advanced cALD. Methods: We performed a longitudinal observational analysis of two paediatric patients with advanced childhood cerebral X-linked adrenoleukodystrophy undergoing repeated neuroregenerative treatment cycles. Standardised scalp electroencephalography was recorded during spontaneous wakefulness and repeated over months under comparable vigilance conditions. Multimodal analysis included conventional EEG, quantitative EEG, independent component analysis, and standardised low-resolution electromagnetic tomography (sLORETA). Clinical function was assessed using validated measures of consciousness, swallowing, and voluntary motor behaviour. Results: Across patients, longitudinal recordings demonstrated sustained stabilisation of consciousness, swallowing, and voluntary motor function, accompanied by reproducible reorganisation of pathological brain rhythms. Delta and theta oscillations showed a consistent topographical redistribution from limbic–frontoinsular networks towards sensorimotor and parietal integrative cortices. These changes were observed across modalities and timepoints and are unlikely to reflect spontaneous fluctuation, delayed effects of haematopoietic stem cell transplantation, or state-dependent EEG variation. Conclusions: Advanced childhood cerebral X-linked adrenoleukodystrophy is associated with disorganisation of endogenous bioelectrical network activity. In this longitudinal analysis, large-scale network reorganisation was temporally associated with sustained clinical stabilisation, supporting a view of late-stage cALD as a dynamic disorder of network-level vulnerability, rather than a fixed terminal state. Full article

Background: Sensorimotor differences have frequently been reported in children with developmental dyslexia, but are often considered secondary or comorbid to phonological deficits. Within an embodied cognition perspective, reading acquisition emerges from dynamic interactions between bodily regulation, multisensory integration, and learning-related neural plasticity. Proprioception contributes to spatial orientation, motor coordination, and perceptual stabilization, while sleep-dependent processes play a critical role in the consolidation and automatization of cognitive and motor skills. Objectives: Building on early clinical observations, including the hypothesis proposed by Martins da Cunha, this review explores whether variations in proprioceptive processing and sensorimotor regulation may influence multisensory stability and the conditions under which reading skills develop in some individuals with dyslexia. Methods: This narrative synthesis integrates clinical observations and experimental paradigms examining proprioceptive function in children with dyslexia, including studies conducted in our laboratory over the past two decades. These investigations address postural regulation under varying attentional demands, laboratory measures of proprioceptive acuity, visuospatial localization tasks, multisensory interactions, and exploratory observations concerning sleep–wake regulation. Results: Across studies, children with dyslexia often show differences in proprioceptive processing associated with variations in postural regulation, visuospatial stability, and multisensory tasks. Laboratory measurements suggest reduced proprioceptive acuity in some individuals, with moderate correlations observed between proprioceptive sensitivity and reading-related measures. Additional observations suggest that nocturnal physiological regulation—including respiratory dynamics and sleep architecture—may interact with daytime sensorimotor stability and attentional functioning. Conclusions: Taken together, these findings support the hypothesis that variations in sensorimotor regulation across the sleep–wake cycle may influence the stability of multisensory processing and attentional conditions relevant for reading acquisition. Within this perspective, proprioception is not proposed as an alternative explanation for dyslexia but as a complementary dimension that may contribute to the heterogeneity of dyslexic profiles. Further longitudinal and controlled studies are required to clarify the relationships between sensorimotor regulation, sleep-dependent plasticity, and learning processes. Full article

Background: Adolescent idiopathic scoliosis (AIS) is often associated with central nervous system disorders and deficits in sensorimotor function. While the Schroth method is a common clinical intervention, research evidence regarding its effectiveness in enhancing sensorimotor control remains limited. This study aimed to evaluate the impact of the Schroth method on sensorimotor control and quality of life (QoL) in AIS patients. Methods: Sixty female participants (mean age 13.4 years) with Cobb angles between 10° and 45° were divided into an intervention group (n = 30), receiving Schroth exercises and bracing for 10 weeks, and a control group (n = 30), receiving bracing alone. Outcome measures included static and dynamic balance, spine lateral flexion joint position sense (JPS), upper-limb functional proprioception, and the GR-BSSQ Brace questionnaire. Results: Statistical analysis using two-way mixed ANOVA revealed significant Group × Time interactions across several parameters. The Schroth group showed significant improvements in static and dynamic balance, with ellipse area reduction (p = 0.005) and reduced Fukuda test distance (p = 0.007), respectively. Significant enhancements were noted in spine lateral flexion JPS (Bilateral p = 0.008) and upper-limb proprioception (Bilateral p = 0.000). Furthermore, the intervention group reported a significant improvement in QoL scores compared to the control (p = 0.000). Conclusions: The findings demonstrate that the Schroth method was associated with enhanced sensorimotor control, supporting its use as a targeted approach to improve functional outcomes in individuals with AIS. These results highlight the clinical value of the method, beyond spinal curve correction. Full article

A recent umbrella review evaluated evidence-based interventions for children with developmental central hypotonia, including those with Down syndrome. Motor, sensorimotor, orthotics, positioning, mobility, and infant massage interventions are supported by positive but low- or very-low-quality evidence. Using a retrospective case report format, these interventions are described, and their proposed mechanism of action is examined through the F-words lens tool and from the perspective of the parent. Tummy time, compression garments, early supported sitting for grasp and reach, ON-Time use of a supported stepping device, and orthotics are all used in the context of coaching in natural environments and family-centered care. Full article

Improving absolute accuracy in industrial manipulators remains difficult because rigid-body kinematic calibration cannot fully represent configuration-dependent non-geometric effects. Drawing inspiration from biological brain–body co-adaptation, this study presents an Evolutionary Neuro-Physical Hybrid (Evo-NPH) framework in which rigid geometric parameters and neural compensator weights are treated as a single co-evolving decision vector. In the offline phase, a Dual-Strategy Adaptive Differential Evolution (DS-ADE) optimizer performs global joint identification using complementary exploration–exploitation behaviors and success-history inheritance, analogous to morphology-control co-evolution in biological systems. In the online phase, a Neuro-Physical Hybrid Jacobian (NPHJ) solver augments the analytical Jacobian with gradients from a Graph Kolmogorov–Arnold Network (GKAN), enabling sensorimotor-like real-time compensation on the learned physical manifold. Experiments on an ABB IRB 120 manipulator with 600 configurations (500 training, 100 testing) report a testing distance-residual RMSE of 0.62 mm, STD of 0.59 mm, and MAX of 0.83 mm. Relative to the uncalibrated baseline, RMSE is reduced by 86.75%; compared with the strongest published baseline, RMSE improves by 23.46%. Ablation results show that joint DS-ADE optimization outperforms a sequential pipeline by 32.6%, and the graph-structured KAN outperforms a parameter-matched MLP by 26.2%. Wilcoxon signed-rank tests ($p<0.001$) confirm statistical significance. Full article

Background: Sensory processing and motor proficiency contribute to movement regulation in adolescent athletes. While motor competence has been widely studied in youth football, the role of trait-level sensory processing remains underexplored. This study examined associations between sensory processing patterns and motor proficiency in adolescent football players. Methods: In this cross-sectional study, 116 male youth football players (mean age: 14.16 ± 1.55 years) from a professional academy completed the Adolescent/Adult Sensory Profile and the Bruininks–Oseretsky Test of Motor Proficiency, Second Edition, Brief Form (BOT-2 BF). Spearman correlations were computed across 36 sensory–motor comparisons, with false discovery rate (FDR) correction applied. Partial correlations controlled for age and years of training. Results: After FDR correction, sensation seeking showed a moderate positive association with fine motor precision (ρ = 0.49, p < 0.001). Low registration demonstrated a large negative association with fine motor integration (ρ = −0.61, p < 0.001) and small-to-moderate negative associations with bilateral coordination and balance (|ρ| = 0.27–0.32). These associations remained significant after adjustment. Conclusions: Sensory processing patterns were differentially associated with coordination- and balance-related motor domains. Findings should be considered exploratory and warrant longitudinal and sport-specific investigation. Full article