Search Results (64)

Climate change is increasingly altering rainfall regimes and hydrological processes, posing major challenges to reservoir operation, flood control, and hydropower production. Understanding its impacts on the Ban Chat reservoir in Northwest Vietnam is therefore crucial for ensuring reliable water resource management under future uncertainties. This study aims to assess potential changes in streamflow to the Ban Chat reservoir under different climate change scenarios. The study employed nine Global Climate Models (GCMs) from the Coupled Model Intercomparison Project Phase 6 (CMIP6) under three Shared Socioeconomic Pathways (SSP1-2.6, SSP2-4.5, and SSP5-8.5). Future climate projections were bias-corrected using the Quantile Delta Mapping (QDM) method and used as input for the Hydrological Engineering Center–Hydrological Modeling System (HEC-HMS) to simulate future inflows. Streamflow changes were evaluated for near- (2021–2040), mid- (2041–2060), and late-century (2061–2080) periods relative to the baseline (1995–2014). Results show that under SSP1-2.6, mean annual discharge and flood-season flows steadily increase (up to +6.9% by 2061–2080), while storage deficits persist (−27.7% to −13.1%). Under SSP2-4.5, changes remain small, with flood peaks limited to +4.5% mid-century, but severe dry-season deficits continue (−29.5% to −24.4%). In contrast, SSP5-8.5 projects strong late-century increases in mean flows (+7.5%) and flood peaks (+8.2%), though early-century flood flows decline (−2.1%). These findings provide essential scientific evidence for adaptive reservoir operation, hydropower planning, and flood risk management, underscoring the significance of incorporating climate scenarios into sustainable water resource strategies in mountainous regions. Full article

Extracellular vesicles (EVs) are mediators of intercellular communication and serve as promising tools for drug discovery and targeted therapies. These lipid bilayer-bound nanovesicles facilitate the transfer of functional proteins, RNAs, lipids, and other biomolecules between cells, thereby influencing various physiological and pathological processes. This review outlines the molecular mechanisms governing EV biogenesis and cargo sorting, emphasizing the role of key regulatory proteins in modulating selective protein packaging. We explore the critical involvement of EVs in various disease microenvironments, including cancer progression, neurodegeneration, and immunological modulation. Their ability to cross biological barriers and deliver bioactive cargo makes them desirable candidates for precise drug delivery systems, especially in neurological and oncological disorders. Moreover, this review highlights advances in engineering EVs for the delivery of RNA therapeutics, CRISPR-Cas systems, and targeted small molecules. The utility of EVs as diagnostic tools in liquid biopsies and their integration into personalized medicine and companion diagnostics are also discussed. Patient-derived EVs offer dynamic insights into disease states and enable real-time treatment stratification. Despite their potential, challenges such as scalable isolation, cargo heterogeneity, and regulatory ambiguity remain significant hurdles. Recent studies have reported novel pharmacological approaches targeting EV biogenesis, secretion, and uptake pathways, with emerging regulators showing promise as drug targets for modulating EV cargo. Future directions include the standardization of EV analytics, scalable biomanufacturing, and the classification of EV-based therapeutics under evolving regulatory frameworks. This review emphasizes the multifaceted roles of EVs and their transformative potential as therapeutic platforms and biomarker reservoirs in next-generation precision medicine. Full article

The shear strength parameters of landslide zones are the necessary data basis for landslide stability evaluation and landslide surge disaster chain research. It is important to determine the physical and mechanical parameters of landslide zones scientifically and reasonably. In this study, four small residual landslide deposits near the Hei Duo Village road in Diebu County, Gansu Province, were investigated. The research involved detailed field investigations, the construction of landslide engineering geological models, and the use of the transfer coefficient method for simultaneous/inverse inversion and sensitivity analysis of the strength parameters of the four landslides. Based on the inversion results, an analysis of the landslide formation mechanism was conducted. The inversion results yielded the shear strength parameters of the sliding surface soil as c = 30.12 kPa and φ = 21.08°. It was found that the excavation at the base of the slope is the direct triggering factor for the landslides, with the 3# landslide being the most affected by the base excavation. In terms of the type of movement, all four landslides belong to the retrogressive landslide, with the maximum shear strain increment mainly concentrated at the slope angle after excavation. The slope body experiences shear failure, which is in good agreement with the field conditions. The study provides reference for stability prediction and disaster prevention and control of reservoir bank slope. Full article

Relative permeability, as a key parameter characterizing multiphase fluid flow behavior in porous media, holds significant importance across various fields, such as reservoir evaluation and engineering geology. However, measuring relative permeability is time-consuming and costly. Considering the analogy between fluid flow and electrical current conduction provides a novel approach for studying multiphase flow characteristics using resistivity data. An integrated oil–water relative permeability and resistivity co-measurement experiment was specifically designed for a complex argillaceous sandstone reservoir in a block, referred to as Block A. Research has shown that as the resistance coefficient increases, the water and oil relative permeability decrease and increase, respectively. As the porosity–permeability comprehensive index increases and the shale content decreases, corresponding to the same resistance coefficient, the water and oil relative permeability show increasing and decreasing trends, respectively. The integration of tortuous capillary tube theory and three-water model concepts, combined with the flow-current similarity principle, has enabled the development of a novel relative permeability–resistivity correlation model that is applicable to complex argillaceous sandstone formations. The application of actual data from the study area shows that the relative errors of the water- and oil-phase relative permeability calculated by the proposed model are both small, at 16% and 8.6%, respectively. The model is validated to better characterize multiphase fluid flow in rocks, offering a new approach for accurately calculating relative permeability based on formation resistivity data. Full article

Shandong Province is rich in geothermal resources, mainly stored in sandstone reservoirs. The setting of reasonable well spacing in the early stage of large-scale recharge has not attracted enough attention. The problem of small well spacing in geothermal engineering is particularly prominent in the sandstone thermal reservoir production area represented by Dezhou. Based on the measured data of temperature, flow, and water level, this paper constructs a typical engineering numerical model by using TOUGH2 software. It is found that when the distance between production and recharge wells is 180 m, the amount of production and recharge is 60 m³/h, and the temperature of reinjection is 30 °C, the temperature of the production well will decrease rapidly after 10 years of production and recharge. In order to solve the problem of thermal breakthrough, three optimization schemes are assumed: reducing the reinjection temperature to reduce the amount of re-injection when the amount of heat is the same, reducing the amount of production and injection when the temperature of production and injection is constant, and stopping production after the temperature of the production well decreases. However, the results show that the three schemes cannot solve the problem of thermal breakthrough or meet production demand. Therefore, it is necessary to set reasonable well spacing. Therefore, based on the strata near the Hydrological Homeland in Decheng District, the reasonable spacing of production and recharge wells is achieved by numerical simulation. Under a volumetric flux scenario ranging from 60 to 80 m³/h, the well spacing should exceed 400 m. For a volumetric flux between 80 and 140 m³/h, it is recommended that the well spacing be greater than 600 m. Full article

The abandoned goaf resulting from coal resource integration in China poses a significant threat to coal mine safety. The transient electromagnetic method (TEM) has emerged as a crucial technology for detecting goafs in coal mines due to its adaptable equipment and efficient implementation. In recent years, small-loop TEM has demonstrated high resolution and adaptability in challenging terrains with vegetation, such as coal mine ponding areas, karst regions, and reservoir seepage scenarios. By considering the sedimentary characteristics of coal seams and addressing the resistivity changes encountered in single-point inversion, a joint optimization inversion process incorporating lateral weighting factors and vertical roughness constraints has been developed to enhance the connectivity between adjacent survey points and improve the continuity of inversion outcomes. Through an OCCAM inversion approach, the regularization factor is dynamically determined by evaluating the norms of the data objective function and model objective function in each iteration, thereby reducing the reliance of inversion results on the initial model. Using the Xiaolong Coal Mine as a geological context, the impact of lateral and vertical weighting factors on the inversion outcomes of high- and low-resistivity structural models is examined through a control variable method. The analysis reveals that optimal inversion results are achieved with a combination of a lateral weighting factor of 0.5 and a vertical weighting factor of 0.1, ensuring both result continuity and accurate depiction of vertical and lateral electrical interfaces. The practical application of this approach validates its effectiveness, offering theoretical support and technical assurance for old goaf detection in coal mines, thereby holding significant engineering value. Full article

The accurate identification of seismic faults, which serve as crucial fluid migration pathways in hydrocarbon reservoirs, is of paramount importance for reservoir characterization. Traditional interpretation is inefficient. It also struggles with complex geometries, failing to meet the current exploration demands. Deep learning boosts fault identification significantly but struggles with edge accuracy and noise robustness. To overcome these limitations, this research introduces SwiftSeis-AWNet, a novel lightweight and high-precision network. The network is based on an optimized MedNeXt architecture for better fault edge detection. To address the noise from simple feature fusion, a Semantics and Detail Infusion (SDI) module is integrated. Since the Hadamard product in SDI can cause information loss, we engineer an Attention-Weighted Semantics and Detail Infusion (AWSDI) module that uses dynamic multi-scale feature fusion to preserve details. Validation on field seismic datasets from the Netherlands F3 and New Zealand Kerry blocks shows that SwiftSeis-AWNet mitigates challenges like the loss of small-scale fault features and misidentification of fault intersection zones, enhancing the accuracy and geological reliability of automated fault identification. Full article

This study presents a GIS-based Weighted Overlay Process (WOP) for Small Hill Reservoir Best Siting (SHRBS) in the Umbria region (central Italy), with a focus on supporting regional-scale planning rather than site-specific engineering design. The WOP incorporated commonly adopted SHRBS criteria, with suitability scores defined through two approaches: Model A, based on scoring scales from the literature, and Model B, which assigns scores based on the frequency distribution of the various attributes observed in a database of over 3000 existing SHRs in the region. The comparison between the models revealed significant differences, particularly in the scores assigned to texture, precipitation, and contributing area. Models A and B, tested on the existing SHRs, indicated quite different average suitability values (2.68 and 3.30, respectively, on a 5-point scale) and only a slight agreement (weighted Cohen’s kappa Kw ≤ 0.13). Both models also showed poor agreement (Kw < 0) when compared with a third suitability model based solely on sedimentation risk, which was developed using the Sediment Delivery Ratio from the InVEST suite. This indicates that many sites considered highly suitable by models A and B were also highly susceptible to sedimentation. Given the economic and environmental implications of sedimentation, this study recommends explicitly incorporating sedimentation risk criteria into SHRBS methodologies to enhance the effectiveness of siting decisions. Full article

HIV-1 Tat acts as a central molecular switch governing the transition between viral latency and active replication, making it a pivotal target for HIV-1 functional cure strategies. By binding to the viral long terminal repeat (LTR) and hijacking host transcriptional machinery, Tat dynamically regulates RNA polymerase II processivity to alter viral transcription states. Recent studies reveal its context-dependent variability: while Tat recruits chromatin modifiers and scaffolds non-coding RNAs to stabilize epigenetic silencing in latently infected cells, it also triggers rapid transcriptional amplification upon cellular activation. This review systematically analyzes the bistable regulatory mechanism of Tat and investigates advanced technologies for reprogramming this switch to eliminateviral reservoirs and achieve functional cures. Conventional approaches targeting Tat are limited by compensatory viral evolution and poor bioavailability. Next-generation interventions will employ precision-engineered tools, such as AI-optimized small molecules blocking Tat-P-TEFb interfaces and CRISPR-dCas9/Tat chimeric systems, for locus-specific LTR silencing or reactivation (“block and lock” or “shock and kill”). Advanced delivery platforms, including brain-penetrant lipid nanoparticles (LNPs), enable the targeted delivery of Tat-editing mRNA or base editors to microglial reservoirs. Single-cell multiomics elucidates Tat-mediated clonal heterogeneity, identifying “switchable” subpopulations for timed interventions. By integrating systems-level Tat interactomics, epigenetic engineering, and spatiotemporally controlled delivery, this review proposes a roadmap to disrupt HIV-1 persistence by hijacking the Tat switch, ultimately bridging mechanistic insights to clinical applications. Full article

Increasing water demand and climate change exacerbate water management challenges in arid and semi-arid regions experiencing water scarcity resulting from low and irregular precipitation and high evapotranspiration. These regions rely on substantial water storage capacity, typically provided by large multi-purpose public reservoirs and small private reservoirs. While public reservoirs are typically monitored, the number, size, and private ownership of small reservoirs complicate effective storage monitoring, hindering efforts to assess water availability during droughts and to allocate water efficiently and equitably. Remote sensing provides a solution to complement existing monitoring systems by offering high spatial and temporal resolution observations. This study introduces a methodology for monitoring the surface area of large and small reservoirs based on optical and radar images from Sentinel-1 and Sentinel-2 satellites. The Normalized Difference Water Index (NDWI) and the Otsu image segmentation method are employed to identify and estimate water body areas, and the Google Earth Engine and programming languages are used to automate the process. The validation results demonstrated correlation for most reservoirs, with slight underestimations at flood peaks. Among the 17 large reservoirs, 16 had an R² value above 0.82, 12 had an RMSE value below 0.8, and 14 had a KGE value above 0.7. For the small reservoirs, the method correctly identified 3224 of the 6370 reservoirs recorded in situ, with greater accuracy in the classes of reservoirs with elevation above 10 m. A total of 7251 reservoirs were mapped, including 4027 not present in the database of the responsible regulatory entity, most with an area of less than 1.8 ha. Performance was better for larger areas (>3 ha), while small areas were underestimated. This methodology offers a practical water management tool adaptable for various-sized surface water bodies, including small, unmonitored water bodies. Full article

Based on the regional disaster system theory, this study constructed a comprehensive flood risk indicator system for small reservoirs, covering the entire flood disaster process from three dimensions: hazard, vulnerability, and exposure. The analytic hierarchy process (AHP) and entropy weight method (EW) were used to determine indicator weights, and a risk assessment was conducted for small reservoirs in Huangshan City, Anhui Province, China. The results indicate that most reservoirs exhibit medium–low overall risk, yet distinct localized high-risk zones exist. High-economic-density areas such as Tunxi District, the central–eastern parts of Huangshan District, and the central and eastern parts of Qimen County have become high-risk clusters due to prominent exposure indicators (numbers of villages and medical facilities). Reservoirs in western and northern regions exhibit higher hazard levels, primarily driven by rainfall and catchment areas. Dam height and reservoir capacity are the main factors affecting vulnerability, with no significant spatial clustering for high-vulnerability reservoirs. Through the decoupling of three-dimensional indicators, this study reveals the differentiated driving mechanisms of “hazard–vulnerability–exposure,” providing a scientific basis for optimizing flood control engineering (e.g., reservoir capacity expansion, dam reinforcement) and risk zoning management (e.g., emergency evacuation planning in high-exposure areas) for small reservoirs. Full article

The seaming of geomembranes (GMBs) is a critical aspect of their successful functioning as barriers to liquid, with bonding and welding being the commonly employed methods. Due to the limitations of conventional welding methods at the connection points between the geomembrane and the structure, extrusion welding often results in damage at the seams. The bonding method, which has lower requirements for construction conditions, has emerged as a currently viable alternative seaming technique. Bonding techniques are widely applied in small reservoirs and embankments. This study investigates the performance of high-density polyethylene (HDPE) GMB seams bonded using asphalt-based adhesive (ABA) and non-asphalt-based adhesive (NABA). Seam tensile tests were conducted under wetting and freeze-thaw cycles (FTCs) conditions to evaluate the mechanical properties of the seamed GMBs. The results indicated that the seam strength of specimens bonded with ABA increased as wetting time and FTCs increased (with a maximum increase of 113.8%). In contrast, specimens bonded with NABA exhibited decreased seam strength under similar conditions (with a maximum decrease of 93.4%). Both types of specimens exhibited enhanced seam strength with increasing seam width. Due to wetting and FTCs, the seam efficiency of NABA-bonded specimens decreased, while that of ABA-bonded specimens showed slight improvement. However, the improved seam efficiency remained below 1.2%, an extremely small value. The axial tensile strength of bonded specimens was significantly lower than that of seamless specimens, failing to fulfill long-term safety operation requirements. Therefore, bonding method should be used cautiously at non-critical structural components where the welding is impractical but repair and replacement are relatively simple. The findings provide insight for GMB installers and design engineers in order to improve the performance of HDPE GMB seams. Full article

With global climate change and the deterioration of the ecological environment, the safety of hydraulic engineering faces severe challenges, among which soil-dwelling termite damage has become an issue that cannot be ignored. Reservoirs and embankments in China, primarily composed of earth and rocks, are often affected by soil-dwelling termites, such as Odontotermes formosanus and Macrotermes barneyi. Identifying soil-dwelling termite damage is crucial for implementing monitoring, early warning, and control strategies. This study developed an improved YOLOv8 model, named MCD-YOLOv8, for identifying traces of soil-dwelling termite activity, based on the Monte Carlo random sampling algorithm and a lightweight module. The Monte Carlo attention (MCA) module was introduced in the backbone part to generate attention maps through random sampling pooling operations, addressing cross-scale issues and improving the recognition accuracy of small targets. A lightweight module, known as dimension-aware selective integration (DASI), was added in the neck part to reduce computation time and memory consumption, enhancing detection accuracy and speed. The model was verified using a dataset of 2096 images from the termite damage survey in hydraulic engineering within Hubei Province in 2024, along with images captured by drone. The results showed that the improved YOLOv8 model outperformed four traditional or enhanced models in terms of precision and mean average precision for detecting soil-dwelling termite damage, while also exhibiting fewer parameters, reduced redundancy in detection boxes, and improved accuracy in detecting small targets. Specifically, the MCD-YOLOv8 model achieved increases in precision and mean average precision of 6.4% and 2.4%, respectively, compared to the YOLOv8 model, while simultaneously reducing the number of parameters by 105,320. The developed model is suitable for the intelligent identification of termite damage in complex environments, thereby enhancing the intelligent monitoring of termite activity and providing strong technical support for the development of termite control technologies. Full article

We review the research on L. fortunei over the past 22 years, systematically elucidating its impacts on ecological environments and water engineering structures. We explored the effects of external factors on the invasion and spread of L. fortunei, as well as the internal factors that impact the ecological environment and water engineering structures. We also provide new perspectives and directions for L. fortunei control. The major research findings include the following: (1) L. fortunei negatively impacts hydraulic structures, being hard to remove and capable of damaging them, disrupting normal operations. (2) L. fortunei’s ecological impact is multifaceted: it reduces water cloudiness and organic matter by filtering suspended particles and depositing feces, but its decay after death consumes dissolved oxygen, increasing chemical oxygen demand and lowering water quality. (3) L. fortunei control techniques are effective for localized use in small bodies of water and aqueducts, but their control in large open reservoirs is difficult to achieve with one method. Existing control methodologies for L. fortunei were systematically evaluated across multiple dimensions, including engineering applicability and feasibility, technical advantages and limitations, and economic cost-effectiveness. This comprehensive analysis establishes a decision-support framework for optimizing control strategy selection in diverse engineering scenarios and application contexts. Full article

In recent years, reservoir flood control and dam safety have faced severe challenges due to changing environmental conditions and intense human activities. There has been a significant increase in the proportion of dam breaks caused by floods exceeding reservoir design levels. Dam breaks have periodically occurred due to flood overtopping, threatening people’s lives and properties. This highlights the importance of describing the challenges encountered in reservoir flood risk prevention and control under extreme climatic conditions and proposing strategies to safeguard reservoirs against floods and to protect downstream communities. This study conducts a statistical analysis of dam breaks resulting from floods exceeding reservoir design levels, revealing new risk indicators in these settings. The study examines recent representative engineering cases involving flood risks and reviews research findings pertaining to reservoir flood risks under extreme climatic conditions. By comparing flood prevention standards at typical reservoirs and investigating the problems and challenges associated with current standards, the study presents the challenges and strategies associated with managing flood risks in reservoirs under extreme climatic conditions. The findings show that the driving forces and their effects shaping flood risk characteristics in specific regions are influenced by atmospheric circulation and vegetative changes in underlying surfaces or land use. There is a clear increasing probability of dam breaks or accidents caused by floods exceeding design levels. Most dam breaks or accidents occur in small and medium-sized reservoirs, due to low flood control standards and poor management. Therefore, this paper recommends measures for improving the flood prevention capacity of these specific types of reservoirs. This paper proposes key measures to cope with floods exceeding reservoir design levels, to supplement the existing standard system. This includes implementing an improved flood standard based on dam risk level and the rapid reduction in the reservoir water level. To prevent breaks associated with overtopping, earth–rock dams should be designed to consider extreme rainfall events. More clarity is needed in the execution principles of flood prevention standards, and the effectiveness of flood calculations should be studied, adjusted, and validated. The research results provide better descriptions of flood risks in reservoirs under extreme climatic conditions, and the proposed strategies have both theoretical and practical implications for building resilience against flood risks and protecting people’s lives and properties. Full article