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19 pages, 1936 KB  
Article
Three-Dimensional Objective Evaluation of the Changes in the Alveolar Ridge Before and After Horizontal Bone Augmentation Along with Implant Placement Using Intraoral Digital Scanning: A Prospective Study
by Naoki Kitamura, Kikue Yamaguchi, Kaiya Himi, Kota Ishii and Motohiro Munakata
J. Funct. Biomater. 2025, 16(9), 312; https://doi.org/10.3390/jfb16090312 (registering DOI) - 28 Aug 2025
Abstract
Implant treatment in the aesthetic regions of the jaw often requires hard and soft tissue augmentation to ensure optimal prosthetic outcomes. Radiological evaluation with cone-beam computed tomography (CBCT) and visual inspection of intraoral photographs are effective for assessing hard tissues but are limited [...] Read more.
Implant treatment in the aesthetic regions of the jaw often requires hard and soft tissue augmentation to ensure optimal prosthetic outcomes. Radiological evaluation with cone-beam computed tomography (CBCT) and visual inspection of intraoral photographs are effective for assessing hard tissues but are limited in evaluating soft tissues. This study aimed to objectively evaluate volumetric and dimensional changes of the alveolar ridge, including both hard and soft tissues, following simultaneous horizontal bone augmentation and implant placement using intraoral digital scanning. Intraoral digital scans were obtained at baseline (T0) and at 2 (T1), 6 (T2), and 12 weeks (T3) post-surgery. Scans were superimposed using dedicated imaging software to measure volumetric and cross-sectional changes. Volumetric gain was significant at T1 but decreased significantly from T1 to T2 (p = 0.0006) and from T1 to T3 (p = 0.0002). Cross-sectional analysis showed significant increases in ridge width at T1 at all measured levels, accompanied by a significant vertical decrease at the alveolar crest from T1 to T2 (p = 0.0056) and T3 (p = 0.0106).These findings indicate that horizontal augmentation provides initial volumetric gain but is followed by substantial reduction at the crest, suggesting that rigid fixation may enhance stability; however, controlled clinical trials are required. Full article
(This article belongs to the Special Issue Recent Advances in Bone Graft Materials)
22 pages, 1645 KB  
Article
Transient Overvoltage Assessment and Influencing Factors Analysis of the Hybrid Grid-Following and Grid-Forming System
by Xindi Liu, Jiawen Cao and Changgang Li
Processes 2025, 13(9), 2763; https://doi.org/10.3390/pr13092763 (registering DOI) - 28 Aug 2025
Abstract
With the large-scale integration of renewable energy devices into the power grid, the voltage stability of the renewable energy base is becoming increasingly weak, and the problem of transient overvoltage is becoming increasingly severe. Grid-forming (GFM) converters can provide strong voltage support. When [...] Read more.
With the large-scale integration of renewable energy devices into the power grid, the voltage stability of the renewable energy base is becoming increasingly weak, and the problem of transient overvoltage is becoming increasingly severe. Grid-forming (GFM) converters can provide strong voltage support. When GFM converters are paralleled with grid-following (GFL) converters, they can effectively reduce transient overvoltage. However, hybrid systems involve many parameters and exhibit complex dynamics, making assessment of transient overvoltage difficult. To address this, this paper first uses Thevenin’s theorem to reduce the renewable transmission system to an equivalent model. Next, the voltage assessment of the hybrid system is analyzed across the pre-fault, mid-fault, and post-fault stages of a short-circuit fault. Then, based on the characteristics of a phase-locked loop (PLL), this paper innovatively derives an assessment method for transient overvoltage at the common coupling point (PCC) under different PLL stability conditions. Additionally, the influence of GFL converter parameters, GFM converter parameters, the GFM capacity ratio on transient overvoltage, and the external system reactance are analyzed. Finally, the proposed evaluation method and factor analysis are validated through electromechanical transient simulation using the simulation software STEPS v2.2.0. Full article
(This article belongs to the Section Energy Systems)
28 pages, 10014 KB  
Article
Nanomaterial Functionalized Carbon Fiber-Reinforced Composites with Energy Storage Capabilities
by Venkatesh Gangipamula, Karamat Subhani, Peter J. Mahon and Nisa Salim
Nanomaterials 2025, 15(17), 1325; https://doi.org/10.3390/nano15171325 (registering DOI) - 28 Aug 2025
Abstract
We have demonstrated the fabrication of laminate composites with functional features to demonstrate energy storage capabilities. The present study investigates the surface modification of carbon fibers by coating dual materials of reduced graphene oxide (rGO) and cellulose-based activated carbon to enhance their energy [...] Read more.
We have demonstrated the fabrication of laminate composites with functional features to demonstrate energy storage capabilities. The present study investigates the surface modification of carbon fibers by coating dual materials of reduced graphene oxide (rGO) and cellulose-based activated carbon to enhance their energy storage capacitance for the development of structural supercapacitors. The dual coating on carbon fibers enabled a near 210-fold improvement in surface area, surpassing that of pristine carbon fibers. This formed a highly porous graphene network with activated carbon, resulting in a well-connected fiber–graphene-activated carbon network on carbon fibers. The electrochemical supercapacitor, fabricated from surface-functionalized carbon fibers, provides the best performance, with a specific capacitance of 172 F g−1 in an aqueous electrolyte. Furthermore, the symmetrical structural supercapacitor (SSSC) device delivered a specific capacitance of 227 mF g−1 across a wide potential window of 6 V. The electrochemical stability of the SSSC device was validated by a high capacitance retention of 97.3% over 10,000 cycles. Additionally, the study showcased the practical application of this technology by successfully illuminating an LED using the proof-of-concept SSSC device with G-aC/CF electrodes. Overall, the findings of this study highlight the potential of carbon fiber composites as a promising hybrid material, offering both structural integrity and a functional performance suitable for aerospace and automobile applications. Full article
(This article belongs to the Special Issue Fabrication and Applications of Polymer Nanocomposite Materials)
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20 pages, 8305 KB  
Article
Fabrication, Microstructure, and High-Temperature Mechanical Properties of a Novel Al-Si-Mg Based Composite Reinforced with Cu-Mn Binary Phase and Submicron Dispersoid
by Kyu-Sik Kim, Abdul Wahid Shah, Jin-Pyung Kim, Si-Young Sung, Kee-Ahn Lee and Min-Su Jeon
Metals 2025, 15(9), 958; https://doi.org/10.3390/met15090958 (registering DOI) - 28 Aug 2025
Abstract
This study reported the development of a novel Al-Si-Mg-based composite reinforced by micron-sized Cu-Mn binary solid solution phases and submicron-sized α-Al(Mn,Fe)Si dispersoids. The Cu-Mn binary solid solution phases were added to the melt in the form of an Al-3%CuMn master alloy, whereas α-Al(Mn,Fe)Si [...] Read more.
This study reported the development of a novel Al-Si-Mg-based composite reinforced by micron-sized Cu-Mn binary solid solution phases and submicron-sized α-Al(Mn,Fe)Si dispersoids. The Cu-Mn binary solid solution phases were added to the melt in the form of an Al-3%CuMn master alloy, whereas α-Al(Mn,Fe)Si dispersoids were obtained via heat treatment. The microstructure analysis confirmed the presence of micron-sized Cu-Mn binary, eutectic Mg2Si, and Al15(FeMn)3Si2 intermetallic phases, submicron-sized α-Al(Mn,Fe)Si dispersoids, and nano-sized precipitates in the Al-based composite. At room temperature, tensile results represented a yield strength of 287 MPa and a tensile strength of 306 MPa, with an elongation of 17%. Moreover, the Al-based composite maintained a yield strength of 277 MPa up to 250 °C, with a slight increase in elongation. The composite also exhibited excellent high-temperature high-cycle fatigue properties and showed a high-cycle fatigue limit of 140 MPa at 130 °C, which is ~2.3 times higher than that of the commercial A319 alloy. A fractography study revealed that the secondary particles hindered the movement of dislocations, thus delaying crack initiation under cyclic loading at high temperatures. Additionally, Cu-Mn binary solid solutions and Al15(FeMn)3Si2 phases were found to be effective in reducing the crack propagation rate by hindering the movement of the propagated crack. Full article
(This article belongs to the Special Issue Light Alloy and Its Application (2nd Edition))
21 pages, 17810 KB  
Article
Mineralogical and Thermochemical Characteristics of Dolomite Induced by Two Marine Microorganisms: Further Insights into Biomineralization
by Dingxiang Zhuang, Weiheng Yao and Songbao Feng
Crystals 2025, 15(9), 767; https://doi.org/10.3390/cryst15090767 (registering DOI) - 28 Aug 2025
Abstract
The mechanism of dolomite has been a major hotspot in geological research. However, most of the current studies mainly focus on single microorganisms and fail to fully consider the influence of marine microbial diversity on the precipitation of carbonate rock minerals. In this [...] Read more.
The mechanism of dolomite has been a major hotspot in geological research. However, most of the current studies mainly focus on single microorganisms and fail to fully consider the influence of marine microbial diversity on the precipitation of carbonate rock minerals. In this paper, two marine microorganisms (Bacillus sp. and Virgibacilus oceani), which can induce dolomite precipitation, were selected to induce dolomite precipitation in a culture solution that simulated the Mg2+/Ca2+ of modern oceans. Four systems were set up in this experiment, including the Bacillus sp. system, the Virgibacilus oceani system, the co-precipitation system (Bacillus sp. and Virgibacilus oceani), and the control system. The synergistic promotion of the dolomite was analyzed by comparing the changes in solution pH, ion consumption, morphology, mineralogical phase, and thermal stability in each experimental group. The experimental results show that the increase in pH value and the consumption of Mg2+ and Ca2+ in the coexistence of Bacillus sp. and Virgibacilus oceani are greater than those in the single microorganism system. The minerals induced by Bacillus sp. and Virgibacilus oceani were mostly small calcium carbonate particles and a small amount of proto-dolomite. However, the faster precipitation rates, larger particle diameters, higher proportion of proto-dolomite, and higher thermal stability of the calcium carbonate and proto-dolomite induced by the two microorganisms suggest that biomineralization facilitates the formation of stable dolomite and accelerates the precipitation of Mg2+ and Ca2+ for bioremediation purposes. Full article
(This article belongs to the Section Mineralogical Crystallography and Biomineralization)
25 pages, 4830 KB  
Article
Ecofriendly PEF- and PBF-Based Blends with Epoxidized Natural Rubber: Unraveling the Structure–Property Relationship
by Sandra Paszkiewicz, Konrad Walkowiak, Izabela Irska, Jakub Śmigielski, Elżbieta Piesowicz, Aleksander Hejna, Beata Dudziec and Mateusz Barczewski
Materials 2025, 18(17), 4040; https://doi.org/10.3390/ma18174040 - 28 Aug 2025
Abstract
Two series of environmentally friendly polymer blends of bio-based poly(ethylene 2,5 furanoate) (PEF) and poly(butylene 2,5 furanoate) (PBF) with epoxidized natural rubber (epNR) have been prepared. Both bio-based polyesters were synthesized from dimethyl furan-2,5-dicarboxylate (DMFDC) and 1,2-ethylene glycol (EG) or 1,4-butylene glycol (BG) [...] Read more.
Two series of environmentally friendly polymer blends of bio-based poly(ethylene 2,5 furanoate) (PEF) and poly(butylene 2,5 furanoate) (PBF) with epoxidized natural rubber (epNR) have been prepared. Both bio-based polyesters were synthesized from dimethyl furan-2,5-dicarboxylate (DMFDC) and 1,2-ethylene glycol (EG) or 1,4-butylene glycol (BG) by a two-stage melt polycondensation process. The miscibility of the components in the blend was assessed using calculations based on Hoy’s method. The chemical interactions, presence of functional groups, miscibility, and possible reactions or cross-linking between polyesters and epNR were analyzed by Fourier Transform Infrared Spectroscopy (FTIR). A significant influence of epNR addition on the melt flow index (MFI), limited viscosity number (LVN), and apparent cross-link density values was also demonstrated. Phase transition temperatures and associated thermal phenomena in polyester/epNR blends were evaluated using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Oxidation onset temperature (OOT) tests were performed to obtain valuable information about the thermal-oxidative stability of the blends. Tensile tests revealed that the addition of epNR to PEF increases flexibility but at the same time reduces stiffness and tensile strength, especially at higher contents of epNR. In the case of PBF, a gradual decrease in tensile strength and elastic modulus is observed with increasing epNR content. Additionally, hardness tests showed that the addition of epNR leads to a decrease in hardness for both PEF- and PBF-based compositions. Full article
(This article belongs to the Section Green Materials)
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24 pages, 6195 KB  
Article
Current Loop Decoupling and Disturbance Rejection for PMSM Based on a Resonant Control Periodic Disturbance Observer
by Jiawei Jin, Liang Guo and Wenqi Lu
Appl. Sci. 2025, 15(17), 9469; https://doi.org/10.3390/app15179469 (registering DOI) - 28 Aug 2025
Abstract
In the vector control of permanent magnet synchronous motor (PMSM), non-periodic disturbances such as cross-coupling between axes and variations in electrical parameters, along with periodic harmonic disturbances caused by inverter nonlinearities and magnetic field harmonics, influence the dq-axis currents. To address these challenges, [...] Read more.
In the vector control of permanent magnet synchronous motor (PMSM), non-periodic disturbances such as cross-coupling between axes and variations in electrical parameters, along with periodic harmonic disturbances caused by inverter nonlinearities and magnetic field harmonics, influence the dq-axis currents. To address these challenges, this paper proposes a current loop disturbance rejection strategy based on a Resonant Control Periodic Disturbance Observer (RC-PDOB). First, this paper constructs a disturbance observer-based current loop decoupling model that mitigates dq-axis current coupling due to parameter variations and reduces the impact of non-periodic disturbances. Then this paper introduces proportional–resonant terms into the disturbance observer to suppress the 6th and 12th harmonics of the dq-axis, thereby reducing periodic current disturbances. This paper analyzes the disturbance rejection mechanism of RC-PDOB in detail and presents the design methodology and stability criteria of the proposed observer. Finally, experimental results demonstrate the effectiveness of the proposed approach. Full article
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12 pages, 2267 KB  
Case Report
Long-Term Follow-Up of a Patient with McCune–Albright Syndrome: A Case Report
by Yuto Shoji, Satoru Kusaka, Kana Kawashima, Shuma Hamaguchi, Meiko Tachikake, Tatsuya Akitomo and Ryota Nomura
J. Clin. Med. 2025, 14(17), 6101; https://doi.org/10.3390/jcm14176101 - 28 Aug 2025
Abstract
Background/Objectives: McCune–Albright syndrome (MAS) is a rare disease characterized by the triad of fibrous dysplasia (FD), café au lait skin macules, and hyperfunctioning endocrinopathies. Although there are many case reports of MAS, few have discussed long-term oral management. We describe the long-term follow-up [...] Read more.
Background/Objectives: McCune–Albright syndrome (MAS) is a rare disease characterized by the triad of fibrous dysplasia (FD), café au lait skin macules, and hyperfunctioning endocrinopathies. Although there are many case reports of MAS, few have discussed long-term oral management. We describe the long-term follow-up of an MAS patient over 15 years. Case Presentation: A male patient aged 13 years and 7 months was referred to our department with a chief complaint of difficulty with toothbrushing. He was diagnosed with MAS at 9 years, and bisphosphonate therapy was started. We continued to review the patient periodically and extracted several primary teeth with no adverse effects such as the medication-related osteonecrosis of the jaw (MRONJ). We evaluated the changes in FD using facial photographs, and facial asymmetry worsened over time until the age of 19, when surgery was performed. Although improvement was observed after surgery, there was a tendency for recurrence up to the age of 25 years. Conclusions: Continuous dental support over 15 years has prevented oral disease and minimized the need for surgical procedures such as tooth extractions, which are factors in MRONJ. The worsening of FD on the left side caused facial asymmetry until the age of 25 years; however, the asymmetry may have stabilized with the development of FD on the right side and with age-related changes. It is important for dental professionals to provide MAS patients with appropriate oral health instruction and oral management, taking changes in FD into consideration. Full article
(This article belongs to the Section Orthopedics)
16 pages, 4631 KB  
Article
Assessment of Additively Manufactured Thermoplastic Composites for Ablative Thermal Protection Systems (TPSs)
by Teodor Adrian Badea, Lucia Raluca Maier and Alexa-Andreea Crisan
Polymers 2025, 17(17), 2338; https://doi.org/10.3390/polym17172338 - 28 Aug 2025
Abstract
This study focused on the thermal stability and ablative behavior assessment of five newly developed composite TPS configurations. All ten test samples were 3D printed via FDM using various fire-retardant thermoplastic materials, with and without reinforcement. Eight samples integrated a new thermal management [...] Read more.
This study focused on the thermal stability and ablative behavior assessment of five newly developed composite TPS configurations. All ten test samples were 3D printed via FDM using various fire-retardant thermoplastic materials, with and without reinforcement. Eight samples integrated a new thermal management internal air chamber conceptualized architecture. A prompt feasible approach for the flame resistance preliminary assessment of ablative TPS samples was developed, using an in-house oxy-acetylene torch test bench. Experimental OTB ablation tests involved exposing the front surface samples to direct flame at 1450 ± 50 °C at 100 mm distance. For each configuration, two samples were tested: one subjected to 30 s of flame exposure and the other to 60 s. During testing, internal temperatures were measured at two backside sample contact points. Recorded temperatures remained below 46 °C, significantly under the maximum allowable back face temperature of 180 °C set for TPSs. The highest mass losses were measured for PC and PETG FR materials, achieving around 19% (30 s) and, respectively, 36% (60 s), while the reinforced configurations showed overall only a third of this reduction. The study’s major outcomes were the internal air chamber concept validation and identifying two reinforced configurations as strong candidates for the further development of 3D-printed ablative TPSs. Full article
(This article belongs to the Section Polymer Applications)
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30 pages, 2240 KB  
Article
Distributionally Robust Bayesian Optimization via Sinkhorn-Based Wasserstein Barycenter
by Iman Seyedi, Antonio Candelieri and Francesco Archetti
Mach. Learn. Knowl. Extr. 2025, 7(3), 90; https://doi.org/10.3390/make7030090 (registering DOI) - 28 Aug 2025
Abstract
This paper introduces a novel framework for Distributionally Robust Bayesian Optimization (DRBO) with continuous context that integrates optimal transport theory and entropic regularization. We propose the sampling from the Wasserstein Barycenter Bayesian Optimization (SWBBO) method to deal with uncertainty about the context; that [...] Read more.
This paper introduces a novel framework for Distributionally Robust Bayesian Optimization (DRBO) with continuous context that integrates optimal transport theory and entropic regularization. We propose the sampling from the Wasserstein Barycenter Bayesian Optimization (SWBBO) method to deal with uncertainty about the context; that is, the unknown stochastic component affecting the observations of the black-box objective function. This approach captures the geometric structure of the underlying distributional uncertainty and enables robust acquisition strategies without incurring excessive computational costs. The method incorporates adaptive robustness scheduling, Lipschitz regularization, and efficient barycenter construction to balance exploration and exploitation. Theoretical analysis establishes convergence guarantees for the robust Bayesian Optimization acquisition function. Empirical evaluations on standard global optimization problems and real-life inspired benchmarks demonstrate that SWBBO consistently achieves faster convergence, good final regret, and greater stability than other recently proposed methods for DRBO with continuous context. Indeed, SWBBO outperforms all of them in terms of both optimization performance and robustness under repeated evaluations. Full article
17 pages, 1244 KB  
Article
Fire Effects on Lichen Biodiversity in Longleaf Pine Habitat
by Roger Rosentreter, Ann DeBolt and Brecken Robb
Forests 2025, 16(9), 1385; https://doi.org/10.3390/f16091385 - 28 Aug 2025
Abstract
Longleaf pine forests are economically important habitats that stabilize and enrich the soil and store carbon over long periods. When mixed with oaks, these forests provide an abundance of lichen habitats. The tree canopy lichens promote greater moisture capture and retention and encourage [...] Read more.
Longleaf pine forests are economically important habitats that stabilize and enrich the soil and store carbon over long periods. When mixed with oaks, these forests provide an abundance of lichen habitats. The tree canopy lichens promote greater moisture capture and retention and encourage canopy insects. Ground lichens limit some vascular plant germination and growth, promoting a more open and healthy pine community. There is a longstanding mutualistic relationship between longleaf pine habitat and lichens. Longleaf pine habitat has a long history of natural summer burning, which promotes a diverse understory and limits tree densities. Lichen diversity exceeds vascular plant diversity in many mature longleaf pine habitats, yet information on the impacts of prescribed fire on lichen species in these habitats is limited. We assessed lichen diversity and abundance before and after a prescribed ground fire in a longleaf pine/wiregrass habitat near Ocala, Florida. Pre-burn, we found greater lichen abundance and diversity on hardwoods, primarily oak species, than on pines. Post-burn, lichen abundance on hardwoods dropped overall by 28%. Lichen abundance on conifers dropped overall by 94%. Ground lichen species were basically eliminated, with a 99.5% loss. Our study provides insights into retaining lichen diversity after a prescribed burn. Hardwood trees, whether alive or standing dead, help retain lichen biodiversity after burning, whereas conifer trees do not support as many species. Landscapes may need to be actively managed by raking pine needle litter away from ground lichen beds, moistening the ground, or removing some lichen material before the burn and returning it to the site post-fire. Based on these results, we suggest retaining some oaks and conducting burns in a mosaic pattern that retains unburned areas. This will allow for lichens to recover between burns, significantly enhancing biodiversity and the ecological health of these longleaf pine communities. Full article
(This article belongs to the Special Issue The Role of Bryophytes and Lichens in Forest Ecosystem Dynamics)
37 pages, 4765 KB  
Review
Mechanochemical Synthesis of Advanced Materials for All-Solid-State Battery (ASSB) Applications: A Review
by Zhiming Qiang, Junjun Hu and Beibei Jiang
Polymers 2025, 17(17), 2340; https://doi.org/10.3390/polym17172340 - 28 Aug 2025
Abstract
Mechanochemical methods have received much attention in the synthesis and design of all-solid-state battery materials in recent years due to their advantages of being green, efficient, easy to operate, and solvent-free. In this review, common mechanochemical methods, including high-energy ball milling, twin-screw extrusion [...] Read more.
Mechanochemical methods have received much attention in the synthesis and design of all-solid-state battery materials in recent years due to their advantages of being green, efficient, easy to operate, and solvent-free. In this review, common mechanochemical methods, including high-energy ball milling, twin-screw extrusion (TSE), and resonant acoustic mixing (RAM), are introduced with the aim of providing a fundamental understanding of the subsequent material design. Subsequently, the discussion focuses on the application of mechanochemical methods in the construction of solid-state electrolytes, anode materials, and cathode materials, especially the research progress of mechanical energy-induced polymerization strategies in building flexible composite electrolytes and enhancing interfacial stability. Through the analysis of representative work, it is demonstrated that mechanochemical methods are gradually evolving from traditional physical processing tools to functional synthesis platforms with chemical reaction capabilities. This review systematically organizes its development and research trends in the field of all-solid-state battery materials and explores potential future breakthrough directions. Full article
(This article belongs to the Special Issue Development of Polymer Materials as Functional Coatings)
21 pages, 46386 KB  
Article
Novel Application of Ultrashort Pulses for Underwater Positioning in Marine Engineering
by Kebang Lu, Minglei Guan, Zheng Cong, Dejin Zhang, Jialong Sun, Haigang Zhang and Keqing Yang
J. Mar. Sci. Eng. 2025, 13(9), 1651; https://doi.org/10.3390/jmse13091651 - 28 Aug 2025
Abstract
Noise interference and multipath effects in complex marine environments seriously constrain the performance of hydroacoustic positioning systems. Traditional millisecond-level signal application and processing methods are widely used in existing research; however, it is difficult to meet the requirements of centimeter-level positioning accuracy in [...] Read more.
Noise interference and multipath effects in complex marine environments seriously constrain the performance of hydroacoustic positioning systems. Traditional millisecond-level signal application and processing methods are widely used in existing research; however, it is difficult to meet the requirements of centimeter-level positioning accuracy in marine engineering. To address this problem, this study proposes a hydroacoustic positioning method based on a short baseline system for the cooperative reception of multi-channel signals. The method adopts ultra-short pulse signals with microsecond pulse width, and significantly improves the system signal-to-noise ratio and anti-interference capability through multi-channel signal alignment and coherent superposition techniques; meanwhile, a joint energy gradient-phase detection algorithm is designed, which solves the instability problem of the traditional cross-correlation algorithm in the detection of ultra-short pulse signals through the identification of signal stability intervals and accurate phase estimation. Simulation verification shows that the 8-hydrophone × 4-channel configuration can achieve 36.06% signal-to-noise gain under harsh environmental conditions (−10 dB), and the performance of the joint energy gradient-phase detection algorithm is improved by about 19.1% compared with the traditional method in an integrated manner. Marine tests further validate the engineering practicability of the method, with an average SNR gain of 2.27 dB achieved for multi-channel signal reception, and the TDOA estimation stability of the new algorithm is up to 32.0% higher than that of the conventional method, which highlights the significant advantages of the proposed method in complex marine environments. The results show that the proposed method can effectively mitigate the noise interference and multipath effects in complex marine environments, significantly improve the accuracy and stability of hydroacoustic positioning, and provide reliable technical support for centimeter-level accuracy applications in marine engineering. Full article
(This article belongs to the Section Ocean Engineering)
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31 pages, 2717 KB  
Article
Ex Vivo Traceability Platform for Phospholipoproteomic Formulations: Functional Evidence Without Clinical Exposure
by Ramón Gutiérrez-Sandoval, Francisco Gutiérrez-Castro, Natalia Muñoz-Godoy, Ider Rivadeneira, Andy Lagos, Ignacio Muñoz, Jordan Iturra, Francisco Krakowiak, Cristián Peña-Vargas, Matías Vidal and Andrés Toledo
Biomedicines 2025, 13(9), 2101; https://doi.org/10.3390/biomedicines13092101 - 28 Aug 2025
Abstract
Background: Structurally active phospholipoproteomic formulations that lack pharmacodynamic targets or systemic absorption present unique challenges for validation. Designed for immune compatibility or structural modulation—rather than therapeutic effect—these platforms cannot be evaluated through conventional clinical or molecular frameworks. Methods: This study introduces a standardized, [...] Read more.
Background: Structurally active phospholipoproteomic formulations that lack pharmacodynamic targets or systemic absorption present unique challenges for validation. Designed for immune compatibility or structural modulation—rather than therapeutic effect—these platforms cannot be evaluated through conventional clinical or molecular frameworks. Methods: This study introduces a standardized, non-invasive ex vivo protocol using real-time kinetic imaging to document biological behavior under neutral conditions. Eight human tumor-derived adherent cell lines were selected for phenotypic stability and imaging compatibility. Phospholipoproteomic preparations were applied under harmonized conditions, and cellular responses were recorded continuously over 48 h. Results: Key parameters included signal continuity, morphological integrity, and inter-batch reproducibility. The system achieved high technical consistency without labeling, endpoint disruption, or destructive assays. Outputs included full kinetic curves and viability signals across multiple cell–fraction pairings. Conclusions: This method provides a regulatorily compatible foundation for functional documentation in non-pharmacodynamic programs where clinical trials are infeasible. It supports early-stage screening, batch comparability, and audit-ready records within SAP, CTD, or real-world evidence (RWE) ecosystems. By decoupling validation from systemic exposure, the protocol enables scalable, technically grounded decision-making for structurally defined immunobiological platforms. Full article
(This article belongs to the Special Issue New Trends in Cancer Immunotherapy)
28 pages, 2681 KB  
Article
A Novel Master Curve Formulation with Explicitly Incorporated Temperature Dependence for Asphalt Mixtures: A Model Proposal with a Case Study
by Gilberto Martinez-Arguelles, Diego Casas, Rita Peñabaena-Niebles, Oswaldo Guerrero-Bustamante and Rodrigo Polo-Mendoza
Infrastructures 2025, 10(9), 227; https://doi.org/10.3390/infrastructures10090227 - 28 Aug 2025
Abstract
Accurately modelling and simulating the stiffness modulus of asphalt mixtures is essential for reliable pavement design and performance prediction under varying environmental and loading conditions. The preceding is commonly achieved through master curves, which relate stiffness to loading frequency at a reference temperature. [...] Read more.
Accurately modelling and simulating the stiffness modulus of asphalt mixtures is essential for reliable pavement design and performance prediction under varying environmental and loading conditions. The preceding is commonly achieved through master curves, which relate stiffness to loading frequency at a reference temperature. However, conventional master curves face two primary limitations. Firstly, temperature is not treated as a state variable; instead, its effect is indirectly considered through shift factors, which can introduce inaccuracies due to their lack of thermodynamic consistency across the entire range of possible temperatures. Secondly, conventional master curves often encounter convergence difficulties when calibrated with experimental data constrained to a narrow frequency spectrum. In order to address these shortcomings, this investigation proposes a novel formulation known as the Thermo-Stiffness Integration (TSI) model, which explicitly incorporates both temperature and frequency as state variables to predict the stiffness modulus directly, without relying on supplementary expressions such as shift factors. The TSI model is built on thermodynamics-based principles (such as Eyring’s rate theory and activation free energy) and leverages the time–temperature superposition principle to create a physically consistent representation of the mechanical behaviour of asphalt mixtures. This manuscript presents the development of the TSI model along with its application in a case study involving eight asphalt mixtures, including four hot-mix asphalts and four warm-mix asphalts. Each type of mixture contains recycled concrete aggregates at replacement levels of 0%, 15%, 30%, and 45% as partial substitutes for coarse natural aggregates. This diverse set of materials enables a robust evaluation of the model’s performance, even under non-traditional mixture designs. For this case study, the TSI model enhances computational stability by approximately 4 to 45 times compared to conventional master curves. Thus, the main contribution of this research lies in establishing a valuable mathematical tool for both scientists and practitioners aiming to improve the design and performance assessment of asphalt mixtures in a more physically realistic and computationally stable approach. Full article
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