Search Results (416)

In this study, the behavior of the spherical bearing component of the L-100 bridge part (AlfaTech LLC, Perm, Russia) is considered within the framework of a finite element model. The influence of the pattern of the coupling of the antifriction interlayer with the lower steel plate on the operation of the part is examined in terms of ideal contact, full adhesion, and frictional contact. The thickness of the antifriction interlayer varied from 4 to 12 mm. The dependencies of the contact parameters and the stress–strain state on the thickness were determined. Structurally modified polytetrafluoroethylene (PTFE) without AR-200 fillers was considered the material of the antifriction interlayer. The gradual refinement of the behavioral model of the antifriction material to account for structural and relaxation transitions was carried based on a wide range of experimental studies. The elastic–plastic and primary viscoelastic models of material behavior were constructed based on a series of homogeneous deformed-state experiments. The viscoelastic model of material behavior was refined using data from dynamic mechanical analysis over a wide temperature range [−40; +80] °C. In the first approximation, a model of the deformation theory of plasticity with linear elastic volumetric compressibility was identified. As a second approximation, a viscoelasticity model for the Maxwell body was constructed using Prony series. It was established that the viscoelastic model of the material allows for obtaining data on the behavior of the part with an error of no more than 15%. The numerical analog of the construction in an axisymmetric formulation can be used for the predictive analysis of the behavior of the bearing, including when changing the geometric configuration. Recommendations for the numerical modeling of the behavior of antifriction layer materials and the coupling pattern of the bearing elements are given in this work. A spherical bearing with an antifriction interlayer made of Arflon series material is considered for the first time. Full article

Endocrine axes are pathways of interactions involved in various aspects of the organism’s functioning, also implicated in deviations from physiological states leading to pathological conditions. The hypothalamic–pituitary–adrenal (HPA) axis releases corticosteroid hormones promoting adaptation to environmental stimuli (acute stress) or inducing altered conditions due to long-term noxious solicitations (chronic stress). The HP–gonadal (HPG) axis regulates reproductive activities by releasing gonadal steroids. These axes have been shown to engage in reciprocal inhibition under certain conditions, particularly when they rise beyond normal ultradian and circadian fluctuations. Based on the literature data, we reconstructed a neuroendocrine network responsible for this type of interaction. Thereafter, we developed a model of the HPA-HPG inhibition based on a series of nonlinear interactions represented by a system of differential equations in the Matlab environment. The quantitative analysis of the system’s behavior revealed the occurrence of bifurcations leading to bistable behavior, allowing us to detect bifurcation parameters. Bifurcation arises as the system’s components increase hypersensitivity and sustained activity in response to activating inputs. This involves transition from a single low-activity attractor to two distinct attractors, with a new high-activity state representing a breakdown of homeostasis. These results provide insights into the potential involvement of the HPA-HPG interaction in neuroendocrine disorders, and the identification of therapeutic targets from bifurcation parameters. Full article

Humans have been using lipids for many centuries; these are oils found in plants, particularly in seeds. However, relatively recently, it has become clear that lipids are the primary metabolites of any living organism. Fatty acids (FAs) are a structural component of lipids, and their role in building the framework of the lipid bilayer cannot be overstated. They participate in maintaining homeostasis by controlling membrane permeability. Changes in the FA composition of lipid bilayers can modulate the transition of the membrane from a liquid crystalline to a gel-like state. Thus, knowledge of a plant’s FA profile can aid in understanding the physiological mechanisms underlying their interaction with the environment and the ways in which they adapt to various stress factors. Throughout the colonization of terrestrial habitats, plants evolved, and new phylogenetic groups appeared; at present, some features of the FA composition of their individual representatives are known. However, the overall change in the composition of lipid FAs during the evolution of higher plants is still not understood. Our analysis of the literature showed that the FA diversity tends to decrease from mosses to angiosperms, mainly due to a reduction in polyunsaturated very-long-chain FAs, while the average acyl chain length remains unchanged. It is important to recognize the trends in this process in order to understand the adaptive capabilities of higher plants. This knowledge can be useful not only from a fundamental point of view, but also in practical human activities. Full article

The fracture evolution of brittle rock under 3D stress states remains poorly understood, particularly the role of deviatoric stress symmetry as characterized by the Lode angle (θ_σ). To address this knowledge gap, we systematically investigated sandstone using a true triaxial loading apparatus under a constant mean stress (100 MPa) while varying θ_σ from −30° to +30°, integrated with real-time acoustic emission (AE) monitoring and post-failure X-ray computed tomography. Our results demonstrate a critical linear reduction in peak strength with increasing θ_σ. This strength reduction is accompanied by a corresponding transition in failure mechanism, from a progressive mode dominated by dilation to an abrupt mode characterized by shear localization. Innovatively, we introduce a novel AE-based parameter (C), derived from the coupled evolution of AE energy and hit rates, which quantifies fracturing intensity in real-time without pre-defined lithological and monitoring scale. Furthermore, digital reconstruction reveals that consistent X-shaped polymodal fault networks are governed by sequential tensile–shear interactions. This key mechanistic insight prompts us to propose a new “deflected shear–tensile hybrid kinked fracture” classification, which more accurately captures the topological complexity of fractures under 3D stresses than conventional monomodal schemes. This study provides fundamental insights into 3D rock fracture mechanics and practical tools for enhancing safety and efficiency in deep geo-engineering. Full article

Cancer cell plasticity, defined as the ability of tumor cells to reversibly adopt distinct functional states, plays a central role in tumor heterogeneity, therapy resistance, and disease relapse. This process enables cells to enter stem-like, dormant, or drug-tolerant persister states in response to treatment or environmental stress without undergoing genetic changes. Such reversible transitions complicate and limit current treatments. Conventional cancer models often fail to capture the complexities of these adaptive states. In contrast, patient-derived tumor organoids (PDOs), which retain the cellular diversity and structure of primary tumors, provide a unique system for investigating plasticity. This review describes how PDOs can model cellular plasticity, such as the emergence of drug-tolerant persister cells and the interconversion between cancer stem cell states across multiple tumor types. We particularly focused on colorectal cancer organoids, for which research on the mechanism of plasticity is the most advanced. Combined with single-cell analysis, lineage tracing, and functional assays, PDOs can help identify the molecular pathways that control plasticity. Understanding these mechanisms is important for developing therapies to prevent treatment failure and control disease progression. Full article

Autonomic dysfunction is a key non-motor feature of Parkinson’s disease (PD) and may influence motor performance, particularly gait. While heart rate variability (HRV) has been associated with freezing of gait, its relationship with broader gait parameters remains unclear. The objective was to investigate correlations between resting-state HRV time-domain measures and spatiotemporal gait parameters during comfortable and fast walking in patients with idiopathic PD. Twenty-eight PD patients (mean age 68 ± 9 years) were evaluated at Campus Bio-Medico University Hospital. HRV was recorded at rest using the e-Sense pule™ portable sensor, including the Baevsky’s Stress Index a measure increasing with sympathetic burden. Gait parameters were assessed via the 10 m Timed Up and Go (TUG) test using the Mon4t™ smartphone app at comfortable and fast pace. Clinical data included UPDRS III, MoCA, and disease characteristics. Gait metrics significantly changed between walking conditions. HRV parameters clustered separately from gait metrics but intersected with significant correlations. Higher Stress Index values, reflecting sympathetic dominance, were associated with poorer gait performance, including prolonged transition times, shorter steps, and increased variability (p < 0.001, r = 0.57–0.61). MoCA scores inversely correlated with the Stress Index (r = −0.52, p = 0.004), linking cognitive and autonomic status. UPDRS III and MoCA were related to TUG metrics but not HRV. Time-domain HRV measures, particularly the Stress Index, are significantly associated with spatiotemporal gait features in PD, independent of gait speed. These findings suggest that impaired autonomic regulation contributes to functional mobility deficits in PD and supports the role of HRV as a biomarker in motor assessment. Full article

Metastasis is the primary cause of cancer-related deaths. As a multi-step process, tumor metastasis encompasses several key aspects. Tumor cells first traverse the basement membrane and subsequently invade the surrounding vascular or lymphatic systems, ultimately leading to secondary colonization. Throughout the progression of metastasis, tumor cells can overcome selective pressures and transition between different cellular states, depending on the diverse functions of mitochondria. Mitochondria not only function as energy generators but also co-evolve with host cells, acting as critical signaling hubs in various biological pathways. Under sustained stress conditions such as nutrient deficiency, cellular stress, and the reprogramming of gene expression, alterations in mitochondrial morphology and function can prevent cell death and facilitate the targeted transformation of oncogenes, tumor progression, and the emergence of invasive cell phenotypes. The multifaceted roles of mitochondria enable tumor cells to evade unfavorable environments and establish colonies in more conducive sites. In summary, this review consolidates the complex interactions between mitochondria and cancer while elucidating their significant role in cancer metastasis and therapeutic responses. Full article

The mechanical properties of high-pressure frozen ice are critical design parameters for deep artificial ground freezing and ice sheet drilling operations, making their investigation fundamentally significant. In this study, ice specimens were prepared at −10 °C under freezing pressures of 10, 20, 30, 40, and 50 MPa. In situ axial loading simulation experiments were conducted to investigate their mechanical behavior and macroscopic deformation characteristics during failure. The experimental results indicate that the deviatoric stress–axial strain curves of the ice specimens exhibited a rapid yet smooth transition before and after reaching the peak deviatoric stress, with all samples exhibiting ductile failure. The peak deviatoric stress initially increased and then decreased with increasing freezing pressure, reaching a maximum value of 8.61 MPa at a critical transition pressure of 20 MPa, eventually declining to a minimum of 1.66 MPa at 50 MPa. The residual deviatoric stress decreased significantly with increasing freezing pressure, declining from approximately 3.5 MPa at 10 MPa to 0.85 MPa at 50 MPa. The peak tangent modulus demonstrated a fluctuating trend with increasing freezing pressure, ranging from 1.76 to 2.37 GPa. As the freezing pressure increased, the failed ice specimens transitioned from a densely cross-cracked state to a highly transparent phase, and finally to a sparsely cross-cracked morphology. Full article

During the transition to adulthood, college students undergo profound personal growth and identity exploration. Spirituality, which is defined as the individual pursuit of meaning, purpose, and connection with others, oneself, and the sacred or transcendent, plays a significant role in shaping well-being, relationships, and academic engagement, independent of organized religion. This qualitative study explores the spiritual aspirations of college students, offering insights into their diverse experiences and values. Participants included 113 ethnically and religiously diverse students from a southern United States urban university who completed an anonymous, open-ended questionnaire focused on spirituality in interpersonal relationships, education, and broader life domains. A thematic analysis identified recurring themes, including “peaceful or less stressed,” “sharing spiritual experiences,” and “being focused.” The findings suggest that the majority of students view spirituality as central to their lives, highlighting its role in their search for meaning, personal development, and a sense of connectedness. These results underscore spirituality as a pervasive influence on student well-being and identity, with implications for their academic and relational experiences. Full article

The effect of dislocation pile-ups responsible for the generation or annihilation of dislocations during friction of Ag and Ni was considered. The steady-state friction was accompanied by the formation of twin bundles, intersecting twins, dislocations, adiabatic elongated shear bands, and intense dynamic recrystallization. The mechanisms of microstructural stability and friction instability were analyzed. The theoretical models of dislocation generation and annihilation in nanocrystalline FCC metals in the context of plastic deformation and failure development under friction were proposed. The transition to unstable friction was estimated. The damage of Ag was exhibited in the formation of pores, reducing the contact area and significantly increasing the shear stress. The brittle fracture of Ni represents a catastrophic failure associated with the formation of super-hard nickel oxide. Deformation resistance of the dislocation structures in the mesoscale and macroscale was compared. The coefficient of similitude (K) has been introduced in this work to compare plastic deformation at different scales. The model of the strength–ductility trade-off and microstructural instability is considered. The interaction between the migration of dislocation pile-ups and the driving forces applied to the grain boundaries was estimated. Nanostructure stabilization through the addition of a polycrystalline element (solute) to the crystal interiors in order to reduce the free energy of grain boundary interfaces was investigated. The thermodynamic driving force and kinetic energy barrier involved in strengthening, brittleness, or annealing under plastic deformation and phase formation in alloys and composite materials were examined. Full article

Traditional landslide monitoring systems struggle to capture the spatiotemporal dynamics of rainfall-induced hydro-mechanical processes, with a significant risk of signal loss during critical “unsaturated-saturated” state transitions. To address this issue, we propose an integrated framework that utilizes FLAC3D numerical simulation to dynamically optimize multi-sensor deployments. Through coupled seepage-stress analysis under different rainfall scenarios in China’s Tianshan Mountains, this study achieved the following objectives: (1) risk-based sensor deployment by precisely identifying shallow shear strain concentration zones (5–15 m) through FLAC3D simulation (with FBG density of 0.5 m/point in the core sliding belt and GNSS spacing ≤ 50 m); (2) establishment of a multi-parameter cooperative early warning system (displacement > 50 mm/h, pore water pressure > 0.4 MPa, strain > 6400 με), where red alerts are triggered when at least two parameters exceed thresholds, reducing false alarm rates; and (3) development of an adaptive sampling framework based on three rainfall intensity scenarios, which increases measurement frequency during heavy rainfall to capture transient critical points (GNSS sampling rate enhanced to 10 Hz). This approach significantly enhances the capture capability of critical hydro-mechanical transition processes while reducing the monitoring redundancy. The framework provides a scientifically robust and reliable solution for slope disaster-risk prevention and management. Full article

The electromagnetic vibration characteristics of doubly fed induction machines (DFIMs) employed in variable-speed pumped storage units, which must accommodate frequent power response and operational mode transitions, serve as critical indicators for assessing unit safety and stability. Nevertheless, there persists a significant research gap regarding generalized vibration analysis models and comprehensive investigations into their steady-state and dynamic vibration performance. To address this challenge, this study develops a universal analytical model for electromagnetic excitation forces in DFIMs using Maxwell’s stress tensor method, explicitly incorporating operational conditions such as rotor eccentricity and load imbalance. Using a 300 MW DFIM as a case study, we employ a hybrid numerical-analytical approach to examine the detrimental effects of harmonic currents generated by rotor-side converters. Furthermore, we systematically analyze how spatial harmonics induced by mechanical faults and temporal harmonics arising from electrical faults collectively influence the electromagnetic vibration behavior. Experimental validation conducted on a 10 MW DFIM prototype through vibration displacement measurements confirms the efficacy of the proposed analytical framework. Full article

As the energy transition advances toward a low-carbon economy, small- and medium-sized consumers are increasingly becoming active prosumers, capable of generating, storing, and managing their own electricity. However, the intermittent nature of renewable sources poses significant challenges in matching generation with consumption, making energy storage a key element for prosumer participation in smart grids. This work assesses the performance of various energy storage technologies suitable for prosumer applications, focusing on parameters such as efficiency, lifecycle behavior, and system integration. Lithium-ion batteries, supercapacitors, and hydrogen-based technologies were tested under real-world operating conditions within residential, commercial, and industrial scenarios. The results confirm that hybrid configurations deliver the most balanced performance, with supercapacitors improving short-term stability in commercial contexts and hydrogen storage enabling long-duration autonomy in industrial settings. In terms of battery state of charge, the experimental tests showed clear differences across prosumer types: in the residential case, it dropped to about 20–25% in the morning, but recovered to nearly full capacity by midday and stabilized at around 70–75% by the end of the day; in the commercial case, it fluctuated more widely, between roughly 18% and 100%, evidencing the highest stress on batteries; while in the industrial case, it reached 25–30% at peak demand, with hydrogen sustaining autonomy under extended load and ensuring greater long-term reliability. Overall, the findings reinforce the importance of tailored storage strategies to unlock the full potential of prosumers in smart grids. Full article

Background: Type 2 diabetes (T2D), the most common form of diabetes, is associated with a significantly elevated risk of cardiovascular and cerebrovascular complications. However, circulating metabolic signatures that reliably predict the transition to insulin resistance, and are potentially linked to increased vascular risk, remain incompletely characterized. Rodent models, particularly those induced by a high-fat diet (HFD) combined with low-dose streptozotocin (STZ), are widely used to study the progression of T2D. However, the systemic metabolic shifts associated with this model, especially at the plasma level, are poorly defined. Methods: In this study, we performed untargeted liquid chromatography–mass spectrometry (LC-MS)-based metabolomic profiling on plasma samples from control, HFD-only (obese, insulin-sensitive), and HFD + STZ (obese, insulin-resistant) C57BL/6 mice. Results: In the HFD + STZ cohort, plasma profiles showed a global shift toward lipid classes; depletion of aromatic and branched-chain amino acids (BCAAs); accumulation of phenylalanine-derived co-metabolites, consistent with gut–liver axis dysregulation; elevations in glucose, fructose-6-phosphate, and nucleoside catabolites, indicating impaired glucose handling and heightened nucleotide turnover; increased free fatty acids, reflecting membrane remodeling and lipotoxic stress; and higher cAMP, thyroxine, hydrocortisone, and uric acid, consistent with endocrine and redox imbalance. By contrast, HFD-only mice exhibited elevations in aromatic amino acids and BCAAs relative to controls, a pattern compatible with early obesity-associated adaptation while insulin signaling remained partially preserved. KEGG analysis revealed disturbances in carbohydrate metabolism, amino acid degradation, nucleotide turnover, and hormone-related pathways, and HMDB mapping linked these changes to T2D, obesity, heart failure, and renal dysfunction. Conclusion: Collectively, these findings delineate insulin resistance-specific plasma signatures of metabolic inflexibility and inflammatory stress in the HFD + STZ model, distinguishing it from HFD alone and supporting its utility for mechanistic studies and biomarker discovery. Importantly, this plasma metabolomics study shows that insulin-sensitive and insulin-resistant states exhibit distinct variation in circulating metabolites and cardiovascular risk factors, underscoring the translational value of plasma profiling. Full article

Single-crystal 4H silicon carbide (4H-SiC) is a key substrate material for third-generation semiconductor devices, where surface and subsurface integrity critically affect performance and reliability. This study systematically examined the evolution of surface morphology and subsurface damage (SSD) during nanoscratching of 4H-SiC under varying normal loads (0–100 mN) using a nanoindenter equipped with a diamond Berkovich tip. Scratch characteristics were assessed using scanning electron microscopy (SEM), while cross-sectional SSD was characterised via focused ion beam (FIB) slicing and transmission electron microscopy (TEM). The results revealed three distinct material removal regimes: ductile removal below 14.5 mN, a brittle-to-ductile transition between 14.5–59.3 mN, and brittle removal above 59.3 mN. Notably, substantial subsurface damage—including median cracks exceeding 4 μm and dislocation clusters—was observed even within the transition zone where the surface appeared smooth. A thin amorphous layer at the indenter-substrate interface suppressed immediate surface defects but promoted subsurface damage nucleation. Crack propagation followed slip lines or their intersections, demonstrating sensitivity to local stress states. These findings offer important insights into nanoscale damage mechanisms, which are essential for optimizing precision machining processes to minimise SSD in SiC substrates. Full article