Search Results (14)

Infective endocarditis (IE) of the tricuspid and pulmonary valve accounts for 5 to 10% of all IE cases and, compared with left-sided IE, is often associated with intravenous (i.v.) drug use, presence of intracardiac devices, and central venous catheters (CVCs), including permanent—Hickman catheter (HC). We report a case of a 71-year-old female patient on a chronic hemodialysis (HD) program who had developed IE. Her first symptoms were fever and malaise. Transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) examinations were performed, revealing vegetations on the tip of HC and the anterior and posterior leaflets of the tricuspid valve (TV). Three blood culture bottles were positive for Enterococcus spp. The HC was replaced with a new CVC to continue HD. After a six-week antibiotic treatment, most clinical symptoms were resolved, and there was a decrease in vegetation size with normalization of inflammatory markers and negative follow-up blood cultures. After this initial improvement in the patient’s condition, the clinical course was complicated by the development of Citrobacter koseri bacteremia and sepsis. Despite adequate antibiotic therapy, the condition progressed to septic shock, which was soon followed by a fatal outcome. IE treatment in HD patients requires long-term broad-spectrum antibiotic therapy, and also, in patients without arteriovenous fistula (AVF), the CVC should be replaced after each HD during IE and sepsis treatment to minimize the patient’s exposure to a foreign body that is susceptible to bacterial colonization. A colonized foreign body is a focus for sustained and spreading infection, and its presence prevents adequate antibiotic treatment until the focus of infection is removed. Full article

Apple Valsa canker, caused by Valsa mali and Valsa pyri, is a devastating disease of apple trees and poses a severe threat to the sustainable development of apple production. Although the two species’ whole genomes have been sequenced, their mitochondrial genomes are still uncharacterized. In this study, the complete mitochondrial genomes of V. mali and V. pyri were assembled, annotated, and compared by bioinformatic methods. The results indicate that the mitogenomes are both circular DNA molecules with sizes of 213,406 bp and 128,022 bp, respectively. The AT skew values of the two Valsa species’ mitogenomes were positive, while the GC skew values were negative. Comparative mitogenome analysis revealed that the length and base composition of protein-coding genes (PCGs), rRNA genes, and tRNA genes differed between the two Valsa species. It was found that the expansion of V. mali was primarily attributable to the intronic regions. There are large numbers of interspersed repetitive sequences (IRS) in both Valsa mitogenomes; however, the proportion of IRS in V. mali (43.56%) was much higher than that in V. pyri (2.41%). The alignment of large fragments between the mitochondrial and nuclear genomes of both V. mali (1.73 kb) and V. pyri (5.17 kb) indicates that gene transfer between mitochondrial and nuclear genomes occurred during evolution. The ka/ks ratios for 15 core PCGs were below one, suggesting that these genes were subjected to purifying selection pressure. Comparative mitogenomics revealed that the two fungi had significant mitogenomic collinearity and large-scale gene rearrangements. The results of phylogenetic analysis based on Bayesian inference (BI) and maximum likelihood (ML) using a combined mitochondrial gene set confirmed that V. mali and V. pyri were fully independent taxa with a high bootstrap value of 100 (ML) and a high posterior probability of 1.0 (BI). This is the first report on the mitogenomes within the genus Valsa. These results will pave the way to understanding the evolution and differentiation of mitogenomes in the genus Valsa. Full article

Visual symmetry activates the extrastriate cortex. This symmetry activation generates an Event Related Potential (ERP) named the Sustained Posterior Negativity (SPN). The SPN is larger when participants engage in regularity discrimination tasks than luminance discrimination tasks. Two recent studies suggest that the type of task matters more when the stimulus is presented briefly. We tested this claim with a new sample of 52 participants in a within-subjects design. As predicted, the SPNs were larger in Regularity tasks than Luminance tasks. However, contrary to predictions, the effect of the task was very similar in long and short presentation duration blocks. It remains unclear what factors modulate the task effect. However, presentation duration is not as important as previous results suggest. Full article

This review of symmetry perception has six parts. Psychophysical studies have investigated symmetry perception for over 100 years (part 1). Neuroscientific studies on symmetry perception have accumulated in the last 20 years. Functional MRI and EEG experiments have conclusively shown that regular visual arrangements, such as reflectional symmetry, Glass patterns, and the 17 wallpaper groups all activate the extrastriate visual cortex. This activation generates an event-related potential (ERP) called sustained posterior negativity (SPN). SPN amplitude scales with the degree of regularity in the display, and the SPN is generated whether participants attend to symmetry or not (part 2). It is likely that some forms of symmetry are detected automatically, unconsciously, and pre-attentively (part 3). It might be that the brain is hardwired to detect reflectional symmetry (part 4), and this could contribute to its aesthetic appeal (part 5). Visual symmetry and fractal geometry are prominent in hallucinations induced by the psychedelic drug N,N-dimethyltryptamine (DMT), and visual flicker (part 6). Integrating what we know about symmetry processing with features of induced hallucinations is a new frontier in neuroscience. We propose that the extrastriate cortex can generate aesthetically fascinating symmetrical representations spontaneously, in the absence of external symmetrical stimuli. Full article

This study provided new data and knowledge on the potential use of Hermetia illucens meal (HIM) as a new sustainable ingredient for Sparus aurata diet. The effect of HIM dietary inclusion on fish growth performance, stress indicators and gut histology was studied. For 131 days, 312 fish were fed a basal diet containing fishmeal as animal protein source, and three diets containing 25%, 35% and 50% HIM as a partial replacement for fishmeal. The main findings indicated that fishmeal can be replaced by HIM up to 110 g/kg of substitution (35% of inclusion in diet) without negative effects on growth performance, stress parameters or histological traits of the posterior gut tract, and with positive effects (p < 0.05) on the histological and morphometric characteristics of the anterior gut tract. At the same time, the results showed that the effect of Hermetia illucens meal at 50% inclusion level caused morphometric and histopathological alterations in the anterior gut tract of seabream. In conclusion, this preliminary study suggested that the dietary inclusion level of HIM35 was the most tolerated by fish showing the best gut morphometric parameters and histological conditions, with fewer signs of inflammation, as well as good nutritional and health status. Full article

The extrastriate visual cortex is activated by visual regularity and generates an ERP known as the sustained posterior negativity (SPN). Spatial filter models offer a biologically plausible account of regularity detection based on the spectral properties of an image. These models are specific to reflection and therefore imply that reflectional symmetry and Glass patterns are coded by different neural populations. We utilised the SPN priming effect to probe representational overlap between reflection and Glass patterns. For each trial, participants were presented with a rapid succession of three patterns. In the Repeated condition, three reflections or three Glass patterns were presented. In the Changing condition, patterns alternated between reflection and Glass patterns. An increase in SPN amplitude (priming) was observed in both the Repeated and Changing conditions. Results indicate a greater representational overlap in the brain between reflection and Glass patterns than predicted by spatial filter models. Full article

EEG, fMRI and TMS studies have implicated the extra-striate cortex, including the Lateral Occipital Cortex (LOC), in the processing of visual mirror symmetries. Recent research has found that the sustained posterior negativity (SPN), a symmetry specific electrophysiological response identified in the region of the LOC, is generated when temporally displaced asymmetric components are integrated into a symmetric whole. We aim to expand on this finding using dynamic dot-patterns with systematically increased intra-pair temporal delay to map the limits of temporal integration of visual mirror symmetry. To achieve this, we used functional near-infrared spectroscopy (fNIRS) which measures the changes in the haemodynamic response to stimulation using near infrared light. We show that a symmetry specific haemodynamic response can be identified following temporal integration of otherwise meaningless dot-patterns, and the magnitude of this response scales with the duration of temporal delay. These results contribute to our understanding of when and where mirror symmetry is processed in the visual system. Furthermore, we highlight fNIRS as a promising but so far underutilised method of studying the haemodynamics of mid-level visual processes in the brain. Full article

Science is starting to unravel the neural basis of romantic love. The goal of this literature review was to identify and interpret the electrophysiological correlates of romantic love. Electroencephalography (EEG) and event-related potential (ERP) studies with a design that elicits romantic love feelings were included. The methods of previous EEG studies are too heterogeneous to draw conclusions. Multiple ERP studies, however, have shown that beloved stimuli elicit an enhanced late positive potential (LPP/P3/P300), which is not due to familiarity, positive valence, or objective beauty. This effect occurs in Western and Eastern cultures and for pictorial and verbal information, and results from bottom-up rather than top-down factors. Studies have also shown that beloved stimuli elicit an early posterior negativity (EPN), which also does not seem to be due to familiarity or positive valence. Data on earlier ERP components (P1, N1, P2, N170/VPP, N2) is scarce and mixed. Of course, the enhanced LPP and EPN are not specific to romantic love. Instead, they suggest that the beloved captures early attention, within 200–300 ms after stimulus onset that is relatively resource-independent, and subsequently receives sustained motivated attention. Future research would benefit from employing cognitive tasks and testing participants who are in love regardless of relationship status. Full article

Using cross-sectional data from 165 countries, this study takes a fresh look at whether or not the sharing economy is a green solution for countries. This study relies on the Timbro sharing economy index and uses both carbon emission and environmental performance index as proxies for the greenhouse gas effect and overall environment, respectively. Due to limited sample size and non-normal distribution of the sample, this paper applies the Bayesian regression model, which is based on posterior distribution. The findings suggest the following: (1) a high sharing economy level has a negative relationship to carbon emissions but a positive relationship to overall environmental performance; (2) the joint variables show that a high sharing economy level together with high broadband access, urbanization, and high education level reduces carbon emissions; and (3) for manufacturing countries, a high sharing economy level together with high urbanization is associated with comparatively low carbon emissions and high environmental performance. In general, these findings allow us to conclude in favor of the contribution made by a high sharing economy level to sustainability. Full article

Sustained focusing on a negative assessment of life events can create negative background and changes in the emotional feedback to new information. In this regard, it is important to assess the balance between self-assessment of emotional memories and their reflection in brain activity. The study was aimed at exploring the brain activity using electroencephalographic (EEG) analysis in six frequency ranges from delta to beta2 during the retrieval of positive or negative emotional memory compared with the resting state. According to ANOVA results, the most informative for differentiation of emotions were the alpha2 and beta2 rhythms with greater synchronization effect for positive than for negative emotions. The memory retrieval, regardless of the valence of emotions, was accompanied by alpha1 desynchronization at the posterior cortex. Self-assessment of the memory intensity was not significantly different due to emotion valences. However, the scores of positive emotions were related positively with beta2 oscillations at the left anterior temporal site, whereas for negative emotions, at the right one. Thus, the emotional autobiographical memory is reflected by activation processes in the visual cortex and areas associated with multimodal information processing, whereas differentiation of the valence of emotions is presented by the high-frequency oscillations at the temporal cortex areas. Full article

Fragaria chiloensis is an herbaceous perennial undomesticated species with a high potential for sustainable fruit production in areas where drought and salinity represent a constraint on crop growth and productivity. The present study aimed to examine the genetic variability of fruit weight, firmness and color parameters (L*, a*, b*, Hue angle and Chroma) in wild-collected accessions from south-central Chile. A Bayesian analysis of genetic parameters showed that the traits under study were found to be moderately to highly heritable with estimates from the marginal posterior distributions ranging between 0.26 (firmness) and 0.67 (L*). Interestingly, Hue and Chroma had relatively high values of broad-sense heritability, with the Bayesian credible set: ${\mathrm{H}}^2$ = 0.53–0.76 and ${\mathrm{H}}^2$ = 0.42–0.66, respectively. A Bayesian bi-trait analysis showed a positive genetic correlation ( ${\hat{\mathrm{r}}}_{\mathrm{g}}$ = 0.65, probability of the posterior samples <0.05) between fruit weight and Hue, which agreed with the existence of two pleiotropic loci [from simple sequence repeats (SSR) markers FvH4045 and CFACT084 on linkage groups FG3A and FG2A/2B/2C] with probabilities of the posterior estimates of 0.022 and <0.001, respectively. According to the Bayesian credible region, 5 (of 12) correlation estimates were significantly different from zero. Hue and Chroma showed a high and negative genetic correlation ( ${\hat{\mathrm{r}}}_{\mathrm{g}}$ = −0.762), but no significant pleotropic locus. The results are promising and suggest that the genetic variation found among wild populations of F. chiloensis supports the idea of domesticating this crop for sustainable fruit production systems. Full article

Diseases affecting the posterior segment of the eye such as age-related macular degeneration and diabetic retinopathy are leading causes of blindness all over the world. The current treatment regimen for such diseases involves repeated intravitreal injections of anti- Vascular Endothelial Growth Factor (VEGF) proteins. This method is highly invasive and can lead to severe complications. In an attempt to develop less invasive alternatives, we propose the use of a controlled release system consisting of anti-VEGF loaded hollow microcapsules that can be administered periocularly to form drug eluting depots on the episcleral surface. The microcapsules with either positive or negative surface charge were prepared by a layer by layer approach and showed pH responsive permeability switching. An ex vivo experiment using porcine sclera indicated positively charged microcapsules remained on the episcleral surface over four days while the negatively charged microcapsules were washed away. These positively charged microcapsules were then loaded with anti-VEGF protein ranibizumab using pH dependent permeability switching and protein release from the microcapsules were studied using an in vitro setup. An ex vivo experiment utilizing porcine sclera demonstrated sustained release of ranibizumab over seven days with zero-order kinetics. Full article

Symmetry is an important cue for the aesthetic judgment of beauty. Using a binary forced-choice format in a cued mixed design, Jacobsen and Höfel (2003) compared aesthetic judgments of beauty and symmetry judgments of novel graphic patterns. A late posterior sustained negativity elicited by symmetric patterns was observed in the symmetry judgment condition, but not in the beauty judgement condition. Therefore, this negativity appeared to be mainly driven by the task.In a series of studies, Bertamini, Makin, and colleagues observed a comparable sustained posterior negativity (SPN) to symmetric stimuli, mainly taken to reflect obligatory symmetry processing independent of task requirements. We reanalyzed the data by Jacobsen and Höfel (2003) using similar parameters for data analysis as Bertamini, Makin, and colleagues to examine these apparent differences. The reanalysis confirmed both a task-driven effect on the posterior sustained negativity/SPN to symmetric patterns in the symmetry judgment condition and a strong symmetry-driven SPN to symmetric patterns. Differences between the references used for analyses of the electroencephalogram (EEG) had an effect. Based on the reanalysis, the Jacobsen and Höfel (2003) data also fit well with Bertamini’s, Makin’s, and colleagues’ account of obligatory symmetry processing. Full article

A number of studies have explored visual symmetry processing by measuring event related potentials and neural oscillatory activity. There is a sustained posterior negativity (SPN) related to the presence of symmetry. There is also functional magnetic resonance imaging (MRI) activity in extrastriate visual areas and in the lateral occipital complex. We summarise the evidence by answering six questions. (1) Is there an automatic and sustained response to symmetry in visual areas? Answer: Yes, and this suggests automatic processing of symmetry. (2) Which brain areas are involved in symmetry perception? Answer: There is an extended network from extrastriate areas to higher areas. (3) Is reflection special? Answer: Reflection is the optimal stimulus for a more general regularity-sensitive network. (4) Is the response to symmetry independent of view angle? Answer: When people classify patterns as symmetrical or random, the response to symmetry is view-invariant. When people attend to other dimensions, the network responds to residual regularity in the image. (5) How are brain rhythms in the two hemispheres altered during symmetry perception? Answer: Symmetry processing (rather than presence) produces more alpha desynchronization in the right posterior regions. Finally, (6) does symmetry processing produce positive affect? Answer: Not in the strongest sense, but behavioural measures reveal implicit positive evaluation of abstract symmetry. Full article