Search Results (3,661)

Surgical site infections (SSIs) remain a significant complication in spine surgery, especially in instrumented procedures with long operative times. Although guidelines recommend cefazolin as the first-line agent due to its efficacy against Staphylococcus aureus, predictable pharmacokinetics, and safety, its real-world practice is highly variable, with inappropriate and prolonged regimens reported across Europe. Vancomycin is often used as the first choice of therapy empirically and without screening, exposing patients to risks such as delayed infusion, nephrotoxicity, and the emergence of vancomycin-resistant enterococci (VRE).This review assesses the present function of vancomycin in relation to cefazolin for spinal prophylaxis and examines wider trends in the misuse of surgical antibiotic prophylaxis, which were identified through PubMed and Scopus searches. Evidence from randomized and prospective studies consistently supports cefazolin as the preferred prophylactic agent in clean spinal surgery. Observational data suggest that adjunctive or topical vancomycin may reduce infection rates in selected high-risk or revision cases, though the results are inconsistent and frequently limited by retrospective designs and heterogeneous outcome reporting. Importantly, the most rigorous randomized controlled trial found no benefit of intrawound vancomycin over the placebo. A small number of available investigations in vancomycin use with major design limitations have resulted in no significant VRE emergency. Unexpectedly, widespread use of vancomycin was followed by a notable transition toward Gram-negative and opportunistic organisms. In summary, vancomycin may only be considered in patients with documented MRSA colonization, β-lactam allergy, or selected revision procedures, but its widespread empirical use as a first-choice therapy is not supported. Full article

With the rapid development of urbanization and tourism in China, increasing attention has been paid to the protection and utilization of historical and cultural heritage, while tourists’ demands for travel experiences have gradually shifted towards in-depth cultural perception. This paper selects Beijing Fayuan Temple Historic and Cultural District as the research case, and adopts methods such as the LDA (Latent Dirichlet Allocation) topic model, collection and analysis of online text data, and field research to explore the current situation of pedestrian space in Fayuan Temple District and its optimization strategies from the perspective of tourists’ perception. The study found that the dimensions of tourists’ perception of the pedestrian space in Fayuan Temple District mainly include six aspects: historical buildings and relics, tour modes and transportation, natural landscapes and environment, historical figures and culture, residents’ life and activities, and tourists’ experiences and visits. By integrating online text data, questionnaire surveys, and on-site behavioral observations, the study constructed a “physical environment-cultural experience-behavioral network” three-dimensional IPA (Importance–Possession Analysis) evaluation model, and analyzed and evaluated the high-frequency perception elements in tourists’ spontaneous evaluations. Based on the current situation evaluation of the pedestrian space in Fayuan Temple District, this paper puts forward optimization strategies for the perception of pedestrian space from the aspects of block space, transportation usage, landscape ecology, digital technology, and cultural symbol translation. It aims to promote the high-quality development of historical blocks by improving and optimizing the pedestrian space, and achieve the dual goals of cultural inheritance and utilization of tourism resources. Full article

Background: Skin diseases of inflammatory origin, such as atopic dermatitis, psoriasis and acne, have a substantial prevalence in the world population. Natural products are particularly important at a topical level. Essential oils are examples of natural products and thyme in particular has been used for medicinal purposes due to its biological properties. Objectives: The aim of present work was to study the anti-inflammatory potential of Thymus mastichina essential oil, focusing on purified terpene-rich fractions. whose major compounds were thymol and linalool, eucalyptol and α-terpineol, and γ-terpinene and terpinolene, respectively. Additionally, a phytocannabinoid formulation containing cannabidiol (CBD) and cannabigerol (CBG) was evaluated to explore potential synergistic effects. Methods: Thymus mastichina essential oil was extracted and purified to obtain terpene-enriched fractions, which were used to develop three distinct formulations. These were screened for antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and assessed for cytotoxicity in HaCaT human keratinocytes. Anti-inflammatory potential was evaluated via gene expression. Selected thyme formulations—alone or in combination with CBD/CBG—were also tested in vivo using a mouse model of acute skin inflammation. Results: The antioxidant activity of the three formulations showed a reduction in DPPH radicals. In addition, the formulations demonstrated to be safe in vitro in the human keratinocyte cell model HaCaT. Under PMA-induced inflammatory stress, the fractions modulated-inflammatory gene expression to varying degrees While terpene fractions alone showed moderate activity, their combination with CBD/CBG enhanced the anti-inflammatory response. In vivo, the gel formulations reduced oedema in a mouse model of acute inflammation. Conclusions: The data support the safe and effective use of Thymus mastichina-derived terpene fractions for topical anti-inflammatory applications. The synergistic effect observed with CBD and CBG suggests that combining essential oil terpenes with phytocannabinoids may offer a novel therapeutic strategy for managing inflammatory skin disorders. Full article

This study evaluates the impact of using group concept maps in the teaching of Applied Thermodynamics in the Bachelor’s Degree in Industrial Electronics and Automation Engineering. The methodology consisted of selecting topics with a high conceptual load, collaboratively creating concept maps, and subsequently evaluating them by both students and teaching staff. Students achieved average scores above 7/10 in the concept map activity, with teacher and student evaluations averaging 7.8 and 7.3, respectively. Knowledge assessment via pre- and post-tests revealed a 20% increase in concept comprehension. For example, in the topic of Principles of Thermodynamics, the percentage of correct answers on the most complex question increased from 13% in the Pre-Test to 40% in the post-test. In the topic of Refrigeration Cycles, some questions showed an improvement from 18% to 25%. The students’ perception of the activity was positive, with an average satisfaction rating of 6.9 out of 10. Furthermore, most students acknowledged that the activity helped them stay engaged with the subject matter and identify errors in their own learning. The high participation in the activity, despite its low impact on the final grade, demonstrates the students’ strong motivation for this study approach. Therefore, the implementation of concept maps not only facilitated the understanding of key concepts but also promoted critical reflection and collaborative learning, establishing itself as an effective strategy in the teaching of Applied Thermodynamics. Full article

Rapid advancements in artificial intelligence and the Internet of Things (IoT) have fueled the growth of furniture, transforming traditional home environments into intelligent living spaces. As consumer adoption accelerates, understanding user concerns and sentiment trends becomes crucial for brands to refine product offerings and enhance market competitiveness. This study systematically investigates consumer concerns and sentiment trends toward furniture products by analyzing user-generated reviews across two major e-commerce platforms: Jingdong and Taobao. Leveraging advanced text-mining methods including TF-IDF keyword extraction, hierarchical clustering, Graph of Words–Latent Dirichlet Allocation (GoW-LDA) topic modeling, and BERT-based sentiment analysis, this research identifies critical user preferences, product satisfaction factors, and platform-specific behavioral patterns. Results reveal distinct cross-platform differences; Jingdong users prioritize service quality, brand trust, and logistical efficiency, whereas Taobao users emphasize product aesthetics, material selection, and cost-effectiveness. The sentiment analysis demonstrates that Jingdong users exhibit more consistent and positive feedback, while sentiment on Taobao displays higher variability due to product-quality discrepancies and price sensitivity. Full article

Field-Programmable Gate Arrays (FPGAs) are increasingly shaping the future of network security, thanks to their flexibility, parallel processing capabilities, and energy efficiency. In this survey, we examine 50 peer-reviewed studies published between 2020 and 2025, selected from an initial pool of 210 articles based on relevance, hardware implementation, and the presence of empirical performance data. These studies encompass a broad range of topics, including cryptographic acceleration, intrusion detection and prevention systems (IDS/IPS), hardware firewalls, and emerging strategies that incorporate artificial intelligence (AI) and post-quantum cryptography (PQC). Our review focuses on five major application areas: cryptographic acceleration, intrusion detection and prevention systems (IDS/IPS), hardware firewalls, and emerging strategies involving artificial intelligence (AI) and post-quantum cryptography (PQC). We propose a structured taxonomy that organises the field by technical domain and challenge, and compare solutions in terms of scalability, resource usage, and real-world performance. Beyond summarising current advances, we explore ongoing limitations—such as hardware constraints, integration complexity, and the lack of standard benchmarking. We also outline future research directions, including low-power cryptographic designs, FPGA–AI collaboration for detecting zero-day attacks, and efficient PQC implementations. This survey aims to offer both a clear overview of recent progress and a valuable roadmap for researchers and engineers working toward secure, high-performance FPGA-based systems. Full article

The present study investigated factors influencing cybersecurity in railway critical infrastructure by identifying relevant factors and criteria and then prioritizing them in order of importance. To address the lack of multi-criteria analysis in previous studies on this topic, the present study applied the analytical hierarchy process to identify factors and criteria influencing cybersecurity and then selected the top 70% of influencing criteria to serve as a reference for railway cybersecurity project management. A total of 25 valid expert questionnaires were collected for weight vector analysis, revealing that the influencing criteria in the top 70% were inability to monitor train occupancy in track sections (locations); inability of controllers to issue commands to safety control systems; inability to provide drivers with information on upcoming signals, block status, and train occupancy; failure to automatically apply brakes when the train exceeds the speed limit; increased risk of catastrophic accidents due to power system security vulnerabilities; and inability of the dispatching system to automatically track train numbers. Full article

Equine sarcoids are the most common dermatological neoplasm in horses worldwide, associated with bovine papillomavirus (BPV) infection and characterized by high recurrence rates after conventional therapies. Bacillus Calmette–Guérin (BCG) immunotherapy has historically been used for sarcoid treatment, yet its role in contemporary veterinary oncology remains debated. This narrative review critically examines the immunological mechanisms, clinical efficacy, and limitations of BCG in equine sarcoid therapy, while integrating insights from comparative oncology and One Health perspectives. A systematic search following PRISMA-based criteria identified 55 relevant studies published over the past four decades. Evidence indicates that BCG activates innate and adaptive immunity through TLR2/4 signaling, macrophage polarization, and enhanced CD8+ T-cell responses, leading to partial or complete sarcoid regression in select cases. However, therapeutic outcomes are highly variable due to heterogeneity in protocols (dose, strain, adjuvant use) and frequent adverse inflammatory reactions. Comparative analyses highlight that modern alternatives—such as cryotherapy, cisplatin-based protocols, and topical imiquimod—achieve higher efficacy and lower recurrence rates in many clinical settings. Although BCG is now rarely considered a first-line therapy, it remains relevant in resource-limited regions, such as the Amazon Biome, where cost-effectiveness and accessibility are critical. Future directions include randomized controlled trials, standardized protocols, and innovative approaches such as checkpoint inhibition, CRISPR-Cas9 targeting of viral oncogenes, and nanoparticle delivery systems. This review provides a balanced and data-driven synthesis of BCG immunotherapy, clarifying its historical contributions, current limitations, and translational opportunities for advancing equine and comparative oncology. Full article

Problem: Amid digital disruption and the cross-fertilization of RBV, DCV, and KBV, strategic management knowledge has grown fragmented with blurred boundaries. Conventional mapping (citation/co-word, LDA) lacks semantic and temporal resolution, obscuring overlaps, divergences, and turning points and hindering links to actionable indicators (e.g., the Balanced Scorecard). Hence, an integrated, semantically faithful, time-stamped map is needed to bridge research and operational metrics. Gap: Prior maps rely on citation/co-word signals, miss textual meaning, and treat RBV/DCV/KBV in isolation—lacking a theory-aligned, time-stamped, manager-oriented synthesis. Objectives: This study aims to (1) reveal how RBV, DCV, and KBV evolve and interrelate over time; (2) produce an integrated, semantically grounded map; and (3) translate selected themes into actionable managerial indicators. Method: We analyzed 25,907 WoS articles (1980–2025) with BERTopic (Sentence-BERT + UMAP + HDBSCAN + c-TF-IDF). We used an RBV/DCV/KBV lexicon to guide retrieval/interpretation (not to constrain modeling). We discovered 230 topics, retained 33 via coherence (C_V), and benchmarked them against LDA. Key findings: A concise set of 33 high-quality themes with a higher C_V than LDA on this corpus was established. A Fish-Scale view (overlapping subfields across economics, management, sociology) that clarifies RBV–DCV–KBV intersections was achieved. Era-sliced prevalence shows how themes emerge and recombine over 1980–2025. Selected themes mapped to Balanced Scorecard (BSC) indicators linking capabilities → processes → customer outcomes → financial results. Contribution: A clear, time-aware synthesis of RBV–DCV–KBV and a scalable, reproducible pipeline for structuring fragmented theory landscapes are presented in this study—bridging scholarly integration with managerial application via BSC mapping. Full article

Glaucoma is a chronic, progressive optic neuropathy characterized by the degeneration of retinal ganglion cells. It is one of the leading causes of blindness worldwide, with elevated intraocular pressure (IOP) being the most significant modifiable risk factor. The objective of this paper is to assess the effectiveness of Direct Selective Laser Trabeculoplasty (DSLT) in the management of glaucoma and OHT based on analysis of available literature. Topical hypotensive medications are the preferred first-line therapy for both newly diagnosed open angle glaucoma (OAG) and ocular hypertension (OHT) over other treatment modalities for most patients. Medical glaucoma management, despite proven efficacy, is limited by issues of patient adherence, quality-of-life decrease, side effects, and ocular surface disease (OSD). Selective Laser Trabeculoplasty (SLT) has emerged as a safe, effective, and repeatable alternative to medical therapy for patients with open-angle glaucoma (OAG) and ocular hypertension (OHT). Direct Selective Laser Trabeculoplasty (DSLT) is a novel, non-contact laser treatment that delivers energy transsclerally to the trabecular meshwork (TM) without the use of a gonioscope. In recent studies, DSLT has demonstrated comparable efficacy to conventional SLT, including the multicenter randomized GLAUrious trial. It reduces IOP by 18–27%, often enabling reduction in or discontinuation of hypotensive topical medications. The non-contact, automated nature of DSLT simplifies the procedure, enhances patient comfort, and may expand access to laser therapy across diverse clinical settings. In conclusion, DSLT represents an innovative advancement in laser therapy for glaucoma, combining the clinical benefits of SLT with enhanced procedural efficiency and safety. Further long-term studies are needed to validate its durability, but existing evidence supports its use as a first-line or adjunctive treatment for OAG and OHT. Full article

Dermatophytes are highly infectious pathogenic fungi that colonize keratinized tissues like skin, hair, and nails, causing superficial infections such as tinea capitis, onychomycosis, tinea corporis, and tinea pedis in humans and animals. In immunocompromised patients, they may invade deeper tissues and organs, leading to severe or life-threatening conditions if untreated or inadequately managed. While most infections respond to topical antifungals, some require complex treatment and show resistance to standard therapies. Therefore, novel antifungal agents are needed. We investigated the antidermatophytic activity of imidazole-thiosemicarbazides against Microsporum canis, Trichophyton spp., and Chrysosporium spp. using the broth microdilution method, comparing results to ketoconazole and amphotericin B through minimal inhibitory concentration (MIC), half-maximal inhibitory concentration (IC₅₀), and selectivity index (SI). Iodine- and bromine-substituted compounds showed the strongest activity, with MICs of 15.15 (IC₅₀ < 1 μM; SI > 213) and 73.46 μg/mL (IC₅₀ < 1 μM; SI > 846) against T. tonsurans, and 3.87 (IC₅₀ = 7.21 μM; SI > 29.6) and 7.38 μg/mL (IC₅₀ = 11.06 μM; SI = 76.6) against M. canis. In silico analysis revealed interactions with α-keratin and lanosterol-14-α demethylase (the azole target enzyme), suggesting enhanced drug retention and action. These findings support these compounds as promising leads for further antifungal development. Full article

Given the construction industry’s significant contribution of approximately 39% of global CO₂ emissions, implementing effective carbon reduction strategies is becoming increasingly critical. In this context, Internet of Things (IoT) technologies present promising solutions for monitoring and reducing emissions. However, there is a lack of comprehensive understanding regarding specific IoT applications, implementation barriers, and opportunities for carbon reduction in construction practices. This study investigates the role of IoT in reducing carbon emissions in the construction industry. Following PRISMA guidelines, this study analyzed bibliometric data from Scopus and Web of Science databases using VOSviewer for science mapping visualization. Content analysis was conducted on 17 carefully selected articles to identify key research topics and applications. The analysis identified four mainstream application areas: (1) IoT-based smart monitoring systems for carbon emissions, (2) energy efficiency and management applications, (3) sustainable construction implementation frameworks, and (4) smart cities and other built environment applications. Key findings highlight growing research interest in IoT applications for sustainable construction, with China, the United States, and the United Kingdom leading collaborative efforts. Despite demonstrated carbon reduction potential, significant implementation barriers exist, including technical limitations, organizational resistance, skill gaps, and economic constraints. Key opportunities include Artificial Intelligence (AI) integration, Building information modeling (BIM)-IoT synergies, energy prosumer models, and standardization frameworks. This study provides the first focused review of IoT applications specifically targeting carbon reduction in construction, highlighting a critical technology-practice gap where organizational factors frequently outweigh technological barriers. A proposed socio-technical integration framework in this study bridges technical and organizational elements to overcome adoption barriers. Full article

Density functional theory calculations are performed to examine the reactivity of the coordinatively unsaturated (NH₃)₄RhO²⁺, (NH₃)₄CoO²⁺, and (NH₃)₄FeO⁺ species with methane and methanol. The ground low-spin state of rhodium oxide provides ideal energetics for the efficient and selective conversion of methane to methanol. The small activation energy barriers for all three steps (H₃C-H activation, CH₃-OH recombination, oxygen reload) promise fast conversion, while the larger activation barrier for the C-H activation of methanol provides the means to kinetically hinder further oxidation to the thermodynamically more favorable formaldehyde. The key finding was that rhodium prefers the 2 + 2 (as opposed to radical) activation mechanism of methane. To maintain the “ideal” electronic structure observed for (NH₃)₄RhO²⁺, we first replaced rhodium with its first-row lower cost counterpart cobalt. The cobalt complex favors a quartet state, which prefers a radical mechanism leading to the formation of methyl radical. This undesired effect vanishes, switching from Co⁴⁺ to Fe³⁺. Possible explanations for the observed trends are provided in terms of electronic structure features of the three metals. The production of methanol from methane has been a topic of intense interest over the past decades and we believe that this work offers new insights for tackling this challenging problem. Full article

The acceleration of industrialization and urbanization have led to the increasingly serious problem of waste gas pollution. Pollutants such as sulfur dioxide (SO₂), nitrogen oxides (NOx), volatile organic compounds (VOCs), ammonia (NH₃), formaldehyde (HCHO), and hydrogen sulfide (H₂S) emitted from industrial production, transportation, and agricultural activities have posed a major threat to the ecological environment and public health. Although traditional physical and chemical treatment methods can partially reduce the concentration of pollutants, they face three core bottlenecks of high cost, high energy consumption, and secondary pollution, and it is urgent to develop sustainable alternative technologies. In this context, probiotic waste gas treatment technology has become an emerging research hotspot due to its environmental friendliness, low energy consumption characteristics, and resource conversion potential. Based on the databases of PubMed, Web of Science Core Collection, Scopus, Embase, and Cochrane Library, this paper systematically searched the literature published from 2014 to 2024 according to the predetermined inclusion and exclusion criteria (such as research topic relevance, experimental data integrity, language in English, etc.). A total of 71 high-quality studies were selected from more than 600 studies for review. By integrating three perspectives (basic theory perspective, environmental application perspective, and waste gas treatment facility perspective), the metabolic mechanism, functional strain characteristics, engineering application status, and cost-effectiveness of probiotics in waste gas bioconversion were systematically analyzed. The main conclusions include the following: probiotics achieve efficient degradation and recycling of waste gas pollutants through specific enzyme catalysis, and compound flora and intelligent regulation can significantly improve the stability and adaptability of the system. This technology has shown good environmental and economic benefits in multi-industry waste gas treatment, but it still faces challenges such as complex waste gas adaptability and long-term operational stability. This review aims to provide useful theoretical support for the optimization and large-scale application of probiotic waste gas treatment technology, promote the transformation of waste gas treatment from ‘end treatment’ to ‘green transformation’, and ultimately serve the realization of sustainable development goals. Full article

Background: Selective serotonin reuptake inhibitors (SSRIs) are one of the most frequently used medication classes in psychiatry, with many approved and off-label uses. One common side effect of SSRIs is sexual dysfunction, leading to the off-label use of SSRIs to manage inappropriate sexual behaviors in psychiatric settings. However, no official guidelines exist for this off-label use of SSRIs, so a review of this use is warranted. Methods: This review was conducted using the PubMed and Google Scholar databases. Grey literature was considered for inclusion in this review, but only one report by the United Kingdom’s Care Quality Commission was included. Peer-reviewed references discussing the theoretical mechanisms of SSRI-induced sexual dysfunction, case reports/studies examining the off-label use of SSRIs, and reviews discussing relevant disorders like post-SSRI sexual dysfunction (PSSD) were included in this review. Results: The literature proposes that SSRIs act through a variety of serotonin receptors such as 5-HT_1A, 5-HT_2A, and 5-HT_2C to inhibit dopaminergic tone in the mesolimbic and spinal pathways to cause sexual dysfunction. Discussion: SSRIs are frequently considered for off-label use in managing inappropriate sexual behavior, particularly in geriatric patients with dementia, given their superior safety profile compared to antipsychotics in that population. However, the risk and treatment options for PSSD are unclear, which poses a risk for patients taking SRRIs, as it can be a severe and enduring condition. High-quality clinical trials are needed, as the majority of the literature on the topic consists of case reports or theoretical papers. Full article