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Article

5 Citations

2,649 Views

14 Pages

Micromechanical Study of Hyperacetylated Nucleosomes Using Single Molecule Transverse Magnetic Tweezers

Santosh Gaire,
Roberto L. Fabian,
Raghabendra Adhikari,
Pamela L. Tuma,
Ian L. Pegg and
Abhijit Sarkar

Int. J. Mol. Sci.2023, 24(7), 6188;https://doi.org/10.3390/ijms24076188

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24 March 2023

Nucleosomes are stable complexes of DNA and histone proteins that are essential for the proper functioning of the genome. These structures must be unwrapped and disassembled for processes such as gene expression, replication, and repair. Histone post...

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Article

15 Citations

12,552 Views

15 Pages

Developing a New Biophysical Tool to Combine Magneto-Optical Tweezers with Super-Resolution Fluorescence Microscopy

Zhaokun Zhou,
Helen Miller,
Adam J.M. Wollman and
Mark C. Leake

Photonics2015, 2(3), 758-772;https://doi.org/10.3390/photonics2030758

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26 June 2015

We present a novel experimental setup in which magnetic and optical tweezers are combined for torque and force transduction onto single filamentous molecules in a transverse configuration to allow simultaneous mechanical measurement and manipulation....

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