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26 pages, 1886 KiB  
Article
Path Planning with Adaptive Autonomy Based on an Improved A Algorithm and Dynamic Programming for Mobile Robots
by Muhammad Aatif, Muhammad Zeeshan Baig, Umar Adeel and Ammar Rashid
Information 2025, 16(8), 700; https://doi.org/10.3390/info16080700 - 17 Aug 2025
Viewed by 158
Abstract
Sustainable path-planning algorithms are essential for executing complex user-defined missions by mobile robots. Addressing various scenarios with a unified criterion during the design phase is often impractical due to the potential for unforeseen situations. Therefore, it is important to incorporate the concept of [...] Read more.
Sustainable path-planning algorithms are essential for executing complex user-defined missions by mobile robots. Addressing various scenarios with a unified criterion during the design phase is often impractical due to the potential for unforeseen situations. Therefore, it is important to incorporate the concept of adaptive autonomy for path planning. This approach allows the system to autonomously select the best path-planning strategy. The technique utilizes dynamic programming with an adaptive memory size, leveraging a cellular decomposition technique to divide the map into convex cells. The path is divided into three segments: the first segment connects the starting point to the center of the starting cell, the second segment connects the center of the goal cell to the goal point, and the third segment connects the center of the starting cell to the center of the goal cell. Since each cell is convex, internal path planning simply requires a straight line between two points within a cell. Path planning uses an improved A (I-A) algorithm, which evaluates the feasibility of a direct path to the goal from the current position during execution. When a direct path is discovered, the algorithm promptly returns and saves it in memory. The memory size is proportional to the square of the total number of cells, and it stores paths between the centers of cells. By storing and reusing previously calculated paths, this method significantly reduces redundant computation and supports long-term sustainability in mobile robot deployments. The final phase of the path-planning process involves pruning, which eliminates unnecessary waypoints. This approach obviates the need for repetitive path planning across different scenarios thanks to its compact memory size. As a result, paths can be swiftly retrieved from memory when needed, enabling efficient and prompt navigation. Simulation results indicate that this algorithm consistently outperforms other algorithms in finding the shortest path quickly. Full article
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27 pages, 4530 KiB  
Article
A Multi-Model BIM-Based Framework for Integrated Digital Transformation of Design to Construction of Large Complex Underground Caverns
by Waqas Arshad Tanoli, Abid Ullah, Abubakar Sharafat and Esam Mohamed Housein Ismaeil
Buildings 2025, 15(16), 2834; https://doi.org/10.3390/buildings15162834 - 11 Aug 2025
Viewed by 395
Abstract
The construction of large underground caverns fundamentally differs from building and above ground civil infrastructure projects due to their complex geometries and variable geological conditions. These projects are complex and challenging because a large amount of data is generated from dispersed, independent, and [...] Read more.
The construction of large underground caverns fundamentally differs from building and above ground civil infrastructure projects due to their complex geometries and variable geological conditions. These projects are complex and challenging because a large amount of data is generated from dispersed, independent, and heterogeneous sources. The underground construction industry often uses traditional project management techniques to manage complex interactions between these data sources that are hardly linked, and independent decisions are often made without considering all the relevant aspects. In this context, cavern construction exhibits uncertainties and risks due to unforeseen circumstances, an intricate design, and ineffective information management. Existing research has considered general BIM semantic models at the design stage; however, the digital transformation of cavern construction remains underdeveloped and fails to integrate digital construction throughout the project lifecycle. To address that gap, a novel BIM-based multi-model cavern information modeling framework is presented here to improve project management, construction, and delivery by integrating multiple interlinked data models and project performance data for large underground cavern construction. Data models of cavern construction processes are linked to propose an extension of the Industry Foundation Classes (IFC) schema based on the cavern-specific elements, relationships, and property set definitions. To illustrate the potential of the proposed framework, a theoretical application to the powerhouse cavern construction is presented. The results indicate that the framework has significant potential to improve construction efficiency and safety and establish a robust foundation for the digital transformation of underground cavern projects. The theoretical implementation on the Neelum–Jhelum powerhouse cavern showed that the framework enabled a 92 m cavern realignment to avoid fault zones, achieved a 12.4% reduction in rock bolt usage, and a 9.8% reduction in shotcrete volume. These quantitative improvements illustrate its potential to enhance safety, reduce material costs, and optimize construction efficiency compared to conventional workflows. Full article
(This article belongs to the Special Issue Advancing Construction and Design Practices Using BIM)
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25 pages, 7748 KiB  
Article
A Deep Learning Approach to Identify Rock Bolts in Complex 3D Point Clouds of Underground Mines Captured Using Mobile Laser Scanners
by Dibyayan Patra, Pasindu Ranasinghe, Bikram Banerjee and Simit Raval
Remote Sens. 2025, 17(15), 2701; https://doi.org/10.3390/rs17152701 - 4 Aug 2025
Viewed by 424
Abstract
Rock bolts are crucial components in the subterranean support systems in underground mines that provide adequate structural reinforcement to the rock mass to prevent unforeseen hazards like rockfalls. This makes frequent assessments of such bolts critical for maintaining rock mass stability and minimising [...] Read more.
Rock bolts are crucial components in the subterranean support systems in underground mines that provide adequate structural reinforcement to the rock mass to prevent unforeseen hazards like rockfalls. This makes frequent assessments of such bolts critical for maintaining rock mass stability and minimising risks in underground mining operations. Where manual surveying of rock bolts is challenging due to the low-light conditions in the underground mines and the time-intensive nature of the process, automated detection of rock bolts serves as a plausible solution. To that end, this study focuses on the automatic identification of rock bolts within medium- to large-scale 3D point clouds obtained from underground mines using mobile laser scanners. Existing techniques for automated rock bolt identification primarily rely on feature engineering and traditional machine learning approaches. However, such techniques lack robustness as these point clouds present several challenges due to data noise, varying environments, and complex surrounding structures. Moreover, the target rock bolts are extremely small objects within large-scale point clouds and are often partially obscured due to the application of reinforcement shotcrete. Addressing these challenges, this paper proposes an approach termed DeepBolt, which employs a novel two-stage deep learning architecture specifically designed for handling severe class imbalance for the automatic and efficient identification of rock bolts in complex 3D point clouds. The proposed method surpasses state-of-the-art semantic segmentation models by up to 42.5% in Intersection over Union (IoU) for rock bolt points. Additionally, it outperforms existing rock bolt identification techniques, achieving a 96.41% precision and 96.96% recall in classifying rock bolts, demonstrating its robustness and effectiveness in complex underground environments. Full article
(This article belongs to the Special Issue New Perspectives on 3D Point Cloud (Third Edition))
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18 pages, 1482 KiB  
Article
Optimizing Power Sharing and Demand Reduction in Distributed Energy Resources for Apartments Through Tenant Incentivization
by Janak Nambiar, Samson Yu, Jag Makam and Hieu Trinh
Energies 2025, 18(15), 4073; https://doi.org/10.3390/en18154073 - 31 Jul 2025
Viewed by 240
Abstract
The increasing demand for electricity in multi-tenanted residential areas has placed unforeseen strain on sub-transformers, particularly in dense urban environments. This strain compromises overall grid performance and challenges utilities with shifting and rising peak demand periods. This study presents a novel approach to [...] Read more.
The increasing demand for electricity in multi-tenanted residential areas has placed unforeseen strain on sub-transformers, particularly in dense urban environments. This strain compromises overall grid performance and challenges utilities with shifting and rising peak demand periods. This study presents a novel approach to enhance the operation of a virtual power plant (VPP) comprising a microgrid (MG) integrated with renewable energy sources (RESs) and energy storage systems (ESSs). By employing an advanced monitoring and control system, the proposed topology enables efficient energy management and demand-side control within apartment complexes. The system supports controlled electricity distribution, reducing the likelihood of unpredictable demand spikes and alleviating stress on local infrastructure during peak periods. Additionally, the model capitalizes on the large number of tenancies to distribute electricity effectively, leveraging locally available RESs and ESSs behind the sub-transformer. The proposed research provides a systematic framework for managing electricity demand and optimizing resource utilization, contributing to grid reliability and a transition toward a more sustainable, decentralized energy system. Full article
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26 pages, 6831 KiB  
Article
Human–Robot Interaction and Tracking System Based on Mixed Reality Disassembly Tasks
by Raúl Calderón-Sesmero, Adrián Lozano-Hernández, Fernando Frontela-Encinas, Guillermo Cabezas-López and Mireya De-Diego-Moro
Robotics 2025, 14(8), 106; https://doi.org/10.3390/robotics14080106 - 30 Jul 2025
Viewed by 453
Abstract
Disassembly is a crucial process in industrial operations, especially in tasks requiring high precision and strict safety standards when handling components with collaborative robots. However, traditional methods often rely on rigid and sequential task planning, which makes it difficult to adapt to unforeseen [...] Read more.
Disassembly is a crucial process in industrial operations, especially in tasks requiring high precision and strict safety standards when handling components with collaborative robots. However, traditional methods often rely on rigid and sequential task planning, which makes it difficult to adapt to unforeseen changes or dynamic environments. This rigidity not only limits flexibility but also leads to prolonged execution times, as operators must follow predefined steps that do not allow for real-time adjustments. Although techniques like teleoperation have attempted to address these limitations, they often hinder direct human–robot collaboration within the same workspace, reducing effectiveness in dynamic environments. In response to these challenges, this research introduces an advanced human–robot interaction (HRI) system leveraging a mixed-reality (MR) interface embedded in a head-mounted device (HMD). The system enables operators to issue real-time control commands using multimodal inputs, including voice, gestures, and gaze tracking. These inputs are synchronized and processed via the Robot Operating System (ROS2), enabling dynamic and flexible task execution. Additionally, the integration of deep learning algorithms ensures precise detection and validation of disassembly components, enhancing accuracy. Experimental evaluations demonstrate significant improvements, including reduced task completion times, enhanced operator experience, and compliance with strict adherence to safety standards. This scalable solution offers broad applicability for general-purpose disassembly tasks, making it well-suited for complex industrial scenarios. Full article
(This article belongs to the Special Issue Robot Teleoperation Integrating with Augmented Reality)
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13 pages, 600 KiB  
Article
Frequentist and Bayesian Estimation Under Progressive Type-II Random Censoring for a Two-Parameter Exponential Distribution
by Rajni Goel, Mahmoud M. Abdelwahab and Tejaswar Kamble
Symmetry 2025, 17(8), 1205; https://doi.org/10.3390/sym17081205 - 29 Jul 2025
Viewed by 287
Abstract
In medical research, random censoring often occurs due to unforeseen subject withdrawals, whereas progressive censoring is intentionally applied to minimize time and resource requirements during experimentation. This work focuses on estimating the parameters of a two-parameter exponential distribution under a progressive Type-II random [...] Read more.
In medical research, random censoring often occurs due to unforeseen subject withdrawals, whereas progressive censoring is intentionally applied to minimize time and resource requirements during experimentation. This work focuses on estimating the parameters of a two-parameter exponential distribution under a progressive Type-II random censoring scheme, which integrates both censoring strategies. The use of symmetric properties in failure and censoring time models, arising from a shared location parameter, facilitates a balanced and robust inferential framework. This symmetry ensures interpretational clarity and enhances the tractability of both frequentist and Bayesian methods. Maximum likelihood estimators (MLEs) are obtained, along with asymptotic confidence intervals. A Bayesian approach is also introduced, utilizing inverse gamma priors, and Gibbs sampling is implemented to derive Bayesian estimates. The effectiveness of the proposed methodologies was assessed through extensive Monte Carlo simulations and demonstrated using an actual dataset. Full article
(This article belongs to the Section Mathematics)
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25 pages, 4047 KiB  
Article
Vulnerability Analysis of the China Railway Express Network Under Emergency Scenarios
by Huiyong Li, Wenlu Zhou, Laijun Zhao, Lixin Zhou and Pingle Yang
Appl. Sci. 2025, 15(15), 8205; https://doi.org/10.3390/app15158205 - 23 Jul 2025
Viewed by 305
Abstract
In the context of globalization and the Belt and Road Initiative, maintaining the stability and security of the China Railway Express network (CRN) is critical for international logistics operations. However, unexpected events can lead to node and edge failures within the CRN, potentially [...] Read more.
In the context of globalization and the Belt and Road Initiative, maintaining the stability and security of the China Railway Express network (CRN) is critical for international logistics operations. However, unexpected events can lead to node and edge failures within the CRN, potentially triggering cascading failures that critically compromise network performance. This study introduces a Coupled Map Lattice model that incorporates cargo flow dynamics, distributing cargo based on distance and the residual capacity of neighboring nodes. We analyze cascading failures in the CRN under three scenarios, isolated node failure, isolated edge disruption, and simultaneous node and edge failure, to assess the network’s vulnerability during emergencies. Our findings show that deliberate attacks targeting cities with high node strength result in more significant damage than attacks on cities with a high node degree or betweenness. Additionally, when edges are disrupted by unexpected events, the impact of edge removals on cascading failures depends on their strategic position and connections within the network, not just their betweenness and weight. The study further reveals that removing collinear edges can effectively slow the propagation of cascading failures in response to deliberate attacks. Furthermore, a single-factor cargo flow allocation method significantly enhances the network’s resilience against edge failures compared to node failures. These insights provide practical guidance and strategic support for the CR Express in mitigating the effects of both unforeseen events and intentional attacks. Full article
(This article belongs to the Section Transportation and Future Mobility)
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23 pages, 60643 KiB  
Article
A Systematic Approach for Robotic System Development
by Simone Leone, Francesco Lago, Doina Pisla and Giuseppe Carbone
Technologies 2025, 13(8), 316; https://doi.org/10.3390/technologies13080316 - 23 Jul 2025
Viewed by 853
Abstract
This paper introduces a unified and systematic design methodology for robotic systems that is generalizable across a wide range of applications. It integrates rigorous mathematical formalisms such as kinematics, dynamics, control theory, and optimization with advanced simulation tools, ensuring that each design decision [...] Read more.
This paper introduces a unified and systematic design methodology for robotic systems that is generalizable across a wide range of applications. It integrates rigorous mathematical formalisms such as kinematics, dynamics, control theory, and optimization with advanced simulation tools, ensuring that each design decision is grounded in provable theory. The approach defines clear phases, including mathematical modeling, virtual prototyping, parameter optimization, and theoretical validation. Each phase builds on the previous one to reduce unforeseen integration issues. Spanning from conceptualization to deployment, it offers a blueprint for developing mathematically valid and robust robotic solutions while streamlining the transition from design intent to functional prototype. By standardizing the design workflow, this framework reduces development time and cost, improves reproducibility across projects, and enhances collaboration among multidisciplinary teams. Such a generalized approach is essential in today’s fast-evolving robotics landscape where rapid innovation and cross-domain applicability demand flexible yet reliable methodologies. Moreover, it provides a common language and set of benchmarks that both novice and experienced engineers can use to evaluate performance, facilitate knowledge transfer, and future-proof systems against emerging application requirements. Full article
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54 pages, 3087 KiB  
Review
Application of Energy Storage Systems to Enhance Power System Resilience: A Critical Review
by Muhammad Usman Aslam, Md Sazal Miah, B. M. Ruhul Amin, Rakibuzzaman Shah and Nima Amjady
Energies 2025, 18(14), 3883; https://doi.org/10.3390/en18143883 - 21 Jul 2025
Viewed by 520
Abstract
The growing frequency and severity of extreme events, both natural and human-induced, have heightened concerns about the resilience of power systems. Enhancing the resilience of power systems alleviates the adverse impacts of power outages caused by unforeseen events, delivering substantial social and economic [...] Read more.
The growing frequency and severity of extreme events, both natural and human-induced, have heightened concerns about the resilience of power systems. Enhancing the resilience of power systems alleviates the adverse impacts of power outages caused by unforeseen events, delivering substantial social and economic benefits. Energy storage systems play a crucial role in enhancing the resilience of power systems. Researchers have proposed various single and hybrid energy storage systems to enhance power system resilience. However, a comprehensive review of the latest trends in utilizing energy storage systems to address the challenges related to improving power system resilience is required. This critical review, therefore, discusses various aspects of energy storage systems, such as type, capacity, and efficacy, as well as modeling and control in the context of power system resilience enhancement. Finally, this review suggests future research directions leading to optimal use of energy storage systems for enhancing resilience of power systems. Full article
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29 pages, 3084 KiB  
Article
The Cascade Transformation of Furfural to Cyclopentanone: A Critical Evaluation Concerning Feasible Process Development
by Christian A. M. R. van Slagmaat
ChemEngineering 2025, 9(4), 74; https://doi.org/10.3390/chemengineering9040074 - 19 Jul 2025
Viewed by 489
Abstract
Furfural is a fascinating bio-based platform molecule that can be converted into useful cyclic compounds, among others. In this work, the hydrogenative rearrangement-dehydration of furfural towards cyclopentanone using a commercially available Pt/C catalyst was investigated in terms of its reaction performance to assess [...] Read more.
Furfural is a fascinating bio-based platform molecule that can be converted into useful cyclic compounds, among others. In this work, the hydrogenative rearrangement-dehydration of furfural towards cyclopentanone using a commercially available Pt/C catalyst was investigated in terms of its reaction performance to assess its feasibility as an industrial process. However, acquiring an acceptable cyclopentanone yield proved very difficult, and the reaction was constrained by unforeseen parameters, such as the relative liquid volume in the reactor and the substrate concentration. Most strikingly, the sacrificial formation of furanoic oligomers that precipitated onto the catalyst’s surface was a troublesome key factor that mediated the product’s selectivity versus the carbon mass balance. By applying a biphasic water–toluene solvent system, the yield of cyclopentanone was somewhat improved to a middling 59%, while tentatively positive distributions of reaction components over these solvent phases were observed, which could be advantageous for anticipated down-stream processing. Overall, the sheer difficulty of controlling this one-pot cascade transformation towards a satisfactory product output under rather unfavorable reaction parameters renders it unsuitable for industrial process development, and a multi-step procedure for this chemical transformation might be considered instead. Full article
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16 pages, 1383 KiB  
Article
Probabilistic Demand Forecasting in the Southeast Region of the Mexican Power System Using Machine Learning Methods
by Ivan Itai Bernal Lara, Roberto Jair Lorenzo Diaz, María de los Ángeles Sánchez Galván, Jaime Robles García, Mohamed Badaoui, David Romero Romero and Rodolfo Alfonso Moreno Flores
Forecasting 2025, 7(3), 39; https://doi.org/10.3390/forecast7030039 - 18 Jul 2025
Viewed by 530
Abstract
This paper focuses on electricity demand forecasting and its uncertainty representation using a hybrid machine learning (ML) model in the eastern control area of southeastern Mexico. In this case, different sources of uncertainty are integrated by applying the Bootstrap method, which adds the [...] Read more.
This paper focuses on electricity demand forecasting and its uncertainty representation using a hybrid machine learning (ML) model in the eastern control area of southeastern Mexico. In this case, different sources of uncertainty are integrated by applying the Bootstrap method, which adds the characteristics of stochastic noise, resulting in a hybrid probabilistic and ML model in the form of a time series. The proposed methodology addresses a function density probability, which is the generalized of extreme values obtained from the errors of the ML model; however, it is adaptable and independent and simulates the variability that may arise due to unforeseen events. Results indicate that for a five-day forecast using only demand data, the proposed model achieves a Mean Absolute Percentage Error (MAPE) of 4.358%; however, incorporating temperature increases the MAPE to 5.123% due to growing uncertainty. In contrast, a day-ahead forecast, including temperature, improves accuracy, reducing MAPE to 1.644%. The stochastic noise component enhances probabilistic modeling, yielding a MAPE of 3.042% with and 2.073% without temperature in five-day forecasts. Therefore, the proposed model proves useful for regions with high demand variability, such as southeastern Mexico, while maintaining accuracy over longer time horizons. Full article
(This article belongs to the Section Power and Energy Forecasting)
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16 pages, 2963 KiB  
Article
Extended Modelling of Molecular Calcium Signalling in Platelets by Combined Recurrent Neural Network and Partial Least Squares Analyses
by Chukiat Tantiwong, Hilaire Yam Fung Cheung, Joanne L. Dunster, Jonathan M. Gibbins, Johan W. M. Heemskerk and Rachel Cavill
Int. J. Mol. Sci. 2025, 26(14), 6820; https://doi.org/10.3390/ijms26146820 - 16 Jul 2025
Viewed by 200
Abstract
Platelets play critical roles in haemostasis and thrombosis. The platelet activation process is driven by agonist-induced rises in cytosolic [Ca2+]i, where the patterns of Ca2+ responses are still incompletely understood. In this study, we developed a number of [...] Read more.
Platelets play critical roles in haemostasis and thrombosis. The platelet activation process is driven by agonist-induced rises in cytosolic [Ca2+]i, where the patterns of Ca2+ responses are still incompletely understood. In this study, we developed a number of techniques to model the [Ca2+]i curves of platelets from a single blood donor. Fura-2-loaded platelets were quasi-simultaneously stimulated with various agonists, i.e., thrombin, collagen, or CRP, in the presence or absence of extracellular Ca2+ entry, secondary mediator effects, or Ca2+ reuptake into intracellular stores. To understand the calibrated time curves of [Ca2+]i rises, we developed two non-linear models, a multilayer perceptron (MLP) network and an autoregressive network with exogenous inputs (NARX). The trained networks accurately predicted the [Ca2+]i curves for combinations of agonists and inhibitors, with the NARX model achieving an R2 of 0.64 for the trend prediction of unforeseen data. In addition, we used the same dataset for the construction of a partial least square (PLS) linear regression model, which estimated the explained variance of each input. The NARX model demonstrated that good fits could be obtained for the nanomolar [Ca2+]i curves modelled, whereas the PLS model gave useful interpretable information on the importance of each variable. These modelling results can be used for the development of novel platelet [Ca2+]i-inhibiting drugs, such as the drug 2-aminomethyl diphenylborinate, blocking Ca2+ entry in platelets, or for the evaluation of general platelet signalling defects in patients with a bleeding disorder. Full article
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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38 pages, 15401 KiB  
Article
Failure Behavior of Aluminum Solar Panel Mounting Structures Subjected to Uplift Pressure: Effects of Foundation Defects
by Sachi Furukawa, Hiroki Mikami, Takehiro Okuji and Koji Takamori
Solar 2025, 5(3), 33; https://doi.org/10.3390/solar5030033 - 15 Jul 2025
Viewed by 374
Abstract
This study investigates the failure behavior of aluminum solar panel mounting structures subjected to uplift pressure, with particular focus on conditions not typically considered in conventional design, specifically, foundation defects. To clarify critical failure modes and evaluate potential countermeasures, full-scale pressure loading tests [...] Read more.
This study investigates the failure behavior of aluminum solar panel mounting structures subjected to uplift pressure, with particular focus on conditions not typically considered in conventional design, specifically, foundation defects. To clarify critical failure modes and evaluate potential countermeasures, full-scale pressure loading tests were conducted. The results showed that when even a single column base was unanchored, structural failure occurred at approximately half the design wind pressure. Although reinforcement measures—such as the installation of uplift-resistant braces—increased the failure pressure to 1.5 times the design value, they also introduced the risk of undesirable failure modes, including panel detachment. Additionally, four-point bending tests of failed members and joints, combined with structural analysis of the frame, demonstrated that once the ultimate strength of each component is known, the likely failure location within the structure can be reasonably predicted. To prevent panel blow-off and progressive failure of column bases and piles, specific design considerations are proposed based on both experimental observations and numerical simulations. In particular, avoiding local buckling in members parallel to the short side of the panels is critical. Furthermore, a safety factor of approximately two should be applied to column bases and pile foundations to ensure structural integrity under unforeseen foundation conditions. Full article
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16 pages, 493 KiB  
Article
Novel Methodology for Determining Necessary and Sufficient Power in Integrated Power Systems Based on the Forecasted Volumes of Electricity Production
by Artur Zaporozhets, Vitalii Babak, Mykhailo Kulyk and Viktor Denysov
Electricity 2025, 6(3), 41; https://doi.org/10.3390/electricity6030041 - 4 Jul 2025
Viewed by 367
Abstract
This study presents a novel methodology for determining zonal electricity generation and capacity requirements corresponding to forecasted annual production in an integrated power system (IPS). The proposed model combines the statistical analysis of historical daily load patterns with a calibration technique to translate [...] Read more.
This study presents a novel methodology for determining zonal electricity generation and capacity requirements corresponding to forecasted annual production in an integrated power system (IPS). The proposed model combines the statistical analysis of historical daily load patterns with a calibration technique to translate forecast total demand into zonal powers (base, semi-peak and peak). A representative reference daily electrical load graph (ELG) is selected from retrospective data using least squares criteria, and a calibration factor α = Wx/Wie scales its zonal outputs to match the forecasted annual generation Wx. The innovation lies in this combination of historical ELG identification and calibration for accurate zonal power prediction. Applying the model to Ukrainian IPS data yields high accuracy: a zonal power error below 1.02% and a generation error below 0.39%. Key contributions include explicitly stating the research questions and hypotheses, providing a schematic procedural description and discussing model limitations (e.g., treatment of renewable variability and omission of meteorological/astronomical factors). Future work is outlined to incorporate unforeseen factors (e.g., post-war demand shifts, electric vehicle adoption) into the forecasting framework. Full article
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18 pages, 1357 KiB  
Article
Dramatic Deterioration of Subclinical Hyperparathyroidism in Children and Adolescents During the Post-COVID-19 Period
by Maria Loutsou, Eleni Dermitzaki, Rodis D. Paparodis, Aspasia N. Michoula, Nicholas Angelopoulos, Panagiotis Christopoulos, Stavros Diamantopoulos, George Mastorakos, Ioanna N. Grivea and Dimitrios T. Papadimitriou
Diseases 2025, 13(7), 198; https://doi.org/10.3390/diseases13070198 - 27 Jun 2025
Viewed by 478
Abstract
Background: Vitamin D is a steroid hormone, essential for the immune system and bone health. Since the sun is meant to provide at least 80% of daily vitamin D requirements, the COVID-19 pandemic is likely to have induced a considerable influence on calcium [...] Read more.
Background: Vitamin D is a steroid hormone, essential for the immune system and bone health. Since the sun is meant to provide at least 80% of daily vitamin D requirements, the COVID-19 pandemic is likely to have induced a considerable influence on calcium metabolism. Methods: We analyzed data from 1138 children, seen in an outpatient pediatric endocrinology clinic from 2022–2023. Vitamin D status was classified as deficiency if 25(OH)D ≤ 20 ng/mL, insufficiency < 30 ng/mL, and sufficiency ≥ 30 ng/mL. Results: Overall, 60.8% of children had vitamin D deficiency or insufficiency worsened with age (p < 0.005), and with adolescent males having higher 25(OH)D concentrations than females (p < 0.05). A negative correlation was found between 25(OH)D and BMI SDS (R2 = 0.02, p < 0.001), and 25(OH)D concentrations varied seasonally, decreasing in winter. Subclinical hyperparathyroidism [parathyroid hormone (PTH) > 45 pg/mL) and normal calcium] was found in 21.5% of children, with 73.5% of them being vitamin D deficient or insufficient. A negative correlation between PTH and 25(OH)D was observed, with PTH plateauing at 25(OH)D above 40 ng/mL (p < 0.001). Conclusions: Compared to the pre-pandemic data (2016–2018), with only 5.1% of children having subclinical hyperparathyroidism (p < 0.001), these findings suggest a marked deterioration in vitamin D status and calcium metabolism in children, with possible unforeseen consequences for bone, immune, and general health. Full article
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