Search Results (1,396)

Objectives: There is a critical need for effective focal therapies for patients with inoperable or anatomically complex tumors where conventional ablation techniques pose high risk or are ineffective. Integrated Nanosecond Pulsed Irreversible Electroporation (INSPIRE) is a novel non-thermal ablation modality which uses real time temperature feedback during pulse delivery to safely treat tumors near critical structures. This study evaluated the impact of exposed electrode length on ablation zone size, reproducibility, and cardiac safety in a large animal model. Methods: INSPIRE treatments were performed in an in vivo healthy porcine liver model. All treatments administered 6000 V 1000 ns pulses with a 45 °C temperature set point. Treatments were administered percutaneously via an electrode and grounding pad approach using an internally cooled electrode applicator. The exposed electrode region at the distal end of the applicator was set to either 0.5, 1.0, 1.5, or 2.0 cm. Ablation zones were assessed via ultrasound, contrast-enhanced CT, and gross pathology one week post-treatment. Cardiac safety was evaluated by measuring pre- and post-treatment serum Troponin levels. Results: All treatments were completed without adverse events. Troponin levels remained stable (pre: 0.249 ng/mL; post: 0.224 ng/mL), indicating no measurable cardiac injury. The 1.5 cm exposure length produced the largest and most consistent ablation volumes, with a mean volume of 12.8 ± 2.6 cm³ and average dimensions of 3.7 × 2.7 cm in under 6 min. Increasing exposure length beyond 1.5 cm introduced greater variability and reduced treatment volumes. Conclusions: INSPIRE enables safe, large-volume, single-applicator ablation without a need for electrical pulse synchronization with R wave in cardiac rhythm. The 1.5 cm exposure length offers optimal balance between energy delivery and treatment consistency. These findings support further clinical investigation of INSPIRE for non-thermal ablation of inoperable tumors. Full article

The research focuses on the National Rural Development Programme (NRDP) during the transition period, assessing the absorption level of sub-measure 4.1, “Investments in agricultural holdings”, which impacts rural development in the agricultural sector in western Romania. A quantitative and qualitative analysis of all selection reports associated with sub-measure 4.1 submitted during the transition period (2021–22) was conducted to investigate a potentially relevant link between the number of beneficiaries identified in the analysed region and their location. Fisher’s exact tests indicate that the null hypothesis, which postulates independence between county and measure in the observed dataset, cannot be rejected. Further empirical analysis was conducted using panel data analysis to identify any relevant regression traits. Tests indicate that funding allocation, the spatial dimension and the temporal dimension are all statistically and substantively significant. Larger budget allocations are associated with a higher volume of proposals. Two out of the four analysed counties systematically outperformed the predicted values in the model by submitting more proposals than would be expected given their budgets. Later application stages yielded a greater number of successful proposals, which is consistent with residual demand capture in sequential competitive calls. Full article

Background: Orthognathic surgery significantly alters the dimensions of the pharyngeal airway. This study’s objective was to assess alterations in the pharyngeal airway volume via cone-beam computed tomography (CBCT) after orthognathic surgery in patients with skeletal Class III malocclusion. Methods: This retrospective study analyzed CBCT images from 23 patients with skeletal Class III malocclusion (13 females, 10 males), who were categorized into two groups based on the surgical approach: double-jaw and single-jaw surgery. The double-jaw group included 13 patients who underwent bilateral sagittal split osteotomy (BSSO) and Le Fort I osteotomy, whereas the single-jaw group included of 10 patients who had underwent BSSO only. CBCT images were evaluated both before surgery and at a minimum of three months after surgery. The oropharyngeal volume (OP), nasopharyngeal volume (NP), total airway volume, posterior airway space (PAS), and the most constricted area at the base of the tongue (minAx) were measured. Statistical analyses were performed using either paired t-tests or Wilcoxon signed-rank tests depending on data normality, with a significance level set at p < 0.01. Results: In the double-jaw group, a significant volumetric increase was observed in the nasopharynx (5316 ± 1948 mm³ to 6064 ± 1899 mm³; p = 0.010) and oropharyngeal volume decreased from 17,097 ± 5675 mm³ to 14,290 ± 5835 mm³; however, this reduction was not statistically significant (p = 0.017). In contrast, the single-jaw group showed a significant reduction in oropharyngeal volume from 15,620 ± 5040 mm³ to 12,444 ± 4701 mm³ (p = 0.010), with no significant change in nasopharyngeal volume (p = 0.551). Total airway volume significantly decreased only in the single-jaw group (from 20,452 ± 7754 mm³ to 16,846 ± 6529 mm³, p = 0.010). Additionally, both groups exhibited marked decreases in PAS and minimum axial area values (all p < 0.01). Conclusions: Orthognathic surgery led to a significant volumetric increase in the nasopharynx in the double-jaw group, whereas the oropharynx volume significantly decreased only in the single-jaw group. Additionally, both surgical approaches resulted in a marked reduction in PAS and minimum axial area values, highlighting a notable impact on posterior airway dimensions. Full article

With the steady global progress in integrating technology into healthcare delivery, doctors’ behavioral patterns on online healthcare platforms have increasingly become a focal point in the fields of digital health and healthcare service management. Grounded in Job Crafting Theory, this study constructs a proactive crafting index, which captures doctors’ proactive behaviors on the platform across three dimensions: consultation rate, number of consultations, and response speed. We systematically examine the multidimensional impacts of such behaviors on performance outcomes, including online consultation volume, offline service volume, and user evaluation performance. This study collects publicly available records from a major online healthcare platform in China and conducts empirical analysis using the entropy weight method and econometric techniques. The results reveal that there is an optimal level of proactive engagement: moderate proactivity maximizes online consultation volume, while both insufficient and excessive proactivity reduce it. Offline service volume, in contrast, follows a U-shaped relationship, where moderate proactive engagement minimizes offline visits, while too little or too much engagement leads to more offline service needs. These nonlinear patterns highlight the importance of framing doctors’ proactive behavior to optimize both online engagement and offline service. The findings enrich Job Crafting Theory by identifying boundaries in platform-based service environments and provide actionable insights for platform operators to design behavior management and incentive systems tailored to doctors’ professional rank, patient condition, and regional context. Full article

We propose the Commodity-Specific Sustainability Index (CSSI), a multidimensional system for quantifying Brazil–China commodity trade dependence that integrates environmental, economic, and social sustainability metrics with conventional trade dynamics. Traditional trade metrics often overlook sustainability risks due to their focus on volume or monetary value. The CSSI combines three dimensions of sustainability risk (environmental impact, economic resilience, and social well-being) into a single assessment framework for major commodities, including soybeans and iron ore. The framework uses a dynamic weighting mechanism that adjusts sub-indices depending on policy priorities and stakeholder inputs, and a Transformer-based time series model captures relationships between CSSI trends with bilateral trade flows along with external shocks, enabling the predictive analysis of sustainability-driven trade adjustments. Furthermore, the CSSI replaces conventional trade volumes with sustainability-adjusted counterparts that are then incorporated into standard trade frameworks such as gravity equations. Our analysis of soybeans and iron ore from 2015 to 2022 shows that conventional dependence metrics overestimate trade dependence by 12–19% (95% CI: 10.8–21.2%, p < 0.001) for commodities with a high environmental footprint. The predictive model, built entirely based on publicly accessible data sources, produces a mean absolute error of 5.5% (±0.8%) in forecasting quarterly trade flows, outperforming ARIMA (6.8% ± 0.5%) and LSTM (6.1% ± 0.6%). The CSSI’s novelty is its holistic approach to sustainability–trade connections, providing policy makers and researchers with a tool to assess long-term commodity resilience, beyond traditional economic metrics. Full article

A novel definition of volume dimension for a mass function based on a sigmoid asymptote is proposed; in particular, we extend the volume dimension of a mass function to define the volume dimensions for nodes and edges in complex networks. Furthermore, the relationship between the proposed volume dimension and the non-specificity term of the Deng entropy is shown, and the traditional volume dimension and volume dimension based on the node degree in complex networks are revisited. Our experiments show that in both real and synthetic complex networks, the volume dimension tends to follow a sigmoidal asymptote rather than the previously utilized power law asymptote. Full article

The stamp technique with bulk-fill composites aims to enhance occlusal surface replication in Class I restorations. Limited research exists on its void formation and volumetric changes. This study measures internal and external voids as well as volumetric changes in occlusal surfaces for both the stamp and conventional bulk-fill techniques. Materials and methods: Twenty-four permanent molars were divided into two groups (n = 12 each): Group 1 (conventional bulk fill) and Group 2 (stamp technique with bulk-fill composite). Standardized Class I cavities were prepared and restored using Tetric EvoCeram^® Bulk Fill composite. Micro-CT scanning was performed before and after restoration to quantify internal and external void percentages and volumetric changes. An independent samples t-test (α = 0.05) was used to compare void percentages and volumetric changes between groups. Results: The mean internal void percentage was similar between groups (Group 1: 0.38 ± 0.22%; Group 2: 0.39 ± 0.30%; p = 0.914), indicating comparable internal adaptation. Group 2 showed a significantly higher external void percentage (17.59 ± 1.76%) compared to Group 1 (9.05 ± 1.98%; p < 0.001), attributed to the stamp technique’s precise replication of occlusal micromorphology, misinterpreted as porosity by analysis software. Fractal dimension analysis revealed that the stamp technique resulted in the formation of a more complex structure. Restoration volumes (Group 1: 34.10 ± 8.09 mm³; Group 2: 35.52 ± 4.80 mm³; p = 0.639) and volumetric changes (Group 1: 5.91 ± 2.72 mm³; Group 2: 4.64 ± 1.31 mm³; p = 0.199) showed no significant differences. in conclusion, the stamp technique produced internal void percentages comparable to the conventional bulk-fill method in Class I restorations. The significantly higher external void percentage in the stamp technique group was due to the accurate replication of occlusal micromorphology, which was detected as porosity by analysis software. No significant differences were observed in volumetric changes of the occlusal surface before and after restoration between the two techniques, supporting the clinical viability of the stamp technique for precise occlusal restorations. Full article

The objective of this paper is to study and analyze an integrated anaerobic digester (AD)–solid oxide fuel cell (SOFC) system, to achieve an energy-efficient waste-to-energy solution. A detailed numerical modeling is developed for plant dimensioning and energy evaluations. The calculation pathway involves determining operational parameters based on specific variables such as the net electric power produced by the SOFC system or the amount of biogas produced by the AD. Three types of biomass—sewage sludge, slaughter waste, and the organic fraction of municipal solid waste (OFMSW)—are considered. The reactor volume required is approximately 24,000 m³ per 1 kg/s of biogas, processing a daily organic substrate of around 900 m³. The calculations reveal a SOFC electric efficiency of 51% and a thermal efficiency of 39%, under the most favorable conditions. In the integrated AD-SOFC layout, net electrical and thermal efficiencies of 47% and 35%, respectively, are achieved. The economic analysis evaluates the investment feasibility under current incentive schemes, considering both the standalone sale of biomethane and the sale of electricity and thermal energy through SOFC integration. A case study evaluates a biomethane facility producing 508 Sm³/h, integrated with an SOFC system capable of generating 2.36 MW_el and 1.74 MW_th of electric and thermal powers. Various scenarios are examined using net present value (NPV) and payback period (PB) analyses. Results show that the PB for the biomethane-only case is 6.46 years. When integrating the SOFC system, the PB is slightly longer—6.58 years in the most favorable scenario—while it increases to 11.55 years under the most likely scenario. Full article

Background: This study examined the influence of creative thinking, shaped by different forms of episodic mental representations, on human movement. The primary objective was to investigate how creativity, elicited through distinct cognitive stimuli, affects movement variability. Methods: Twenty-four professional dancers developed two original dance phrases, each inspired by either a visual or a narrative mental representation. Movement data were collected via inertial sensor technology and subsequently analysed to determine differences in motor expression. Results: The results indicated that movements performed under narrative representation conditions exhibited significantly increased risk-taking behaviour, greater movement amplitude, and a higher overall movement volume compared to those guided by visual stimuli. Conclusions: These findings underscore the role of creativity in modulating both the expressive and physical dimensions of human movement. Moreover, this research demonstrates the potential of inertial sensor technology not only to capture kinematic patterns but also to provide insight into the deeper layers of human artistic and cognitive processes. Full article

Background: The thalamus, together with its associated nuclei and thalamocortical pathways, is crucial in understanding the neurobiological mechanisms underlying auditory verbal hallucinations (AVHs) in schizophrenia (SCZ). Purpose: The study investigates the role of thalamic nuclei in schizophrenia patients experiencing auditory verbal hallucinations (AVHs). Methods: A total of 21 healthy controls (HC), 22 schizophrenia patients without auditory verbal hallucinations (SCZ_AVH−), and 22 schizophrenia patients with auditory verbal hallucinations (SCZ_AVH+), aged between 19 and 65 years, were recruited. They underwent MRI scans, and participants in the SCZ_AVH+ group completed the assessment of the severity of different dimensions of auditory hallucinations and delusions using the psychotic symptom rating scale (PSYRATS). High-resolution T1-weighted imaging was utilized to analyze the volumes of the thalamic nuclei. Results: The volumetric analysis of the thalamic nuclei indicated a significant reduction (t = 2.64, p = 0.03) in the right medial geniculate nucleus (MGN) volume in the SCZ_AVH+ group (0.08 ± 0.01 cm³) compared to the SCZ_AVH− group (0.09 ± 0.01 cm³). Also, the SCZ_AVH− group (0.03 ± 0 cm³) showed a significant increase (t = −2.73, p = 0.02) in right habenular nucleus (HN) volume compared to the HC group (0.02 ± 0 cm³). Significant correlations were observed between the volume of the left MGN and psychotic ratings (r= −0.5), as well as between the volume of the right HN and psychotic ratings (r= 0.56). Conclusion: The volumetric changes are observed in both SCZ_AVH− and SCZ_AVH+ groups, mainly in the thalamic nuclei. Structural deficits in the MGN may distinguish schizophrenia patients with AVHs from those without. Full article

The often used analytical representation of the Maxwell–Boltzmann classical speed distribution function (F) for elastic, indivisible particles assumes an infinite limit for the speed. Consequently, volume and the number of particles (n) extend to infinity: Both infinities contradict assumptions underlying this non-relativistic formulation. Finite average kinetic energy and temperature (T) result from normalization of F removing n: However, total energy (i.e., heat of the collection) remains infinite because n is infinite. This problem persists in recent adaptations. To better address real (finite) systems, wherein T depends on heat, we generalize this one-parameter distribution (F, cast in energy) by proposing a two-parameter gamma distribution function (F*) in energy which reduces to F at large n. Its expectation value of kT (k = Boltzmann’s constant) replicates F, whereas the shape factor depends on n and affects the averages, as expected for finite systems. We validate F* via a first-principle, molecular dynamics numerical model of energy and momentum conserving collisions for 26, 182, and 728 particles in three-dimensional physical space. Dimensionless calculations provide generally applicable results; a total of 10⁷ collisions suffice to represent an equilibrated collection. Our numerical results show that individual momentum conserving collisions in three-dimensions provide symmetrical speed distributions in all Cartesian directions. Thus, momentum and energy conserving collisions are the physical cause for equipartitioning of energy: Validity of this theorem for other systems depends on their specific motions. Our numerical results set upper limits on kinetic energy of individual particles; restrict the n particles to some finite volume; and lead to a formula in terms of n for conserving total energy when utilizing F* for convenience. Implications of our findings on matter under extreme conditions are briefly discussed. Full article

Background: The aim of this study was to evaluate the cervical regeneration process following monopolar electrosurgical conization (MESC), using a multimodal approach including ultrasonographic, cytologic, colposcopic, and histologic assessments, and to determine the relationship between the extent of excision and the capacity for cervical tissue regeneration. Methods: This prospective observational study included 28 patients who underwent MESC due to abnormal cervical cytology or biopsy-confirmed cervical intraepithelial neoplasia. Preoperative, postoperative one month and six month cervical measurements were obtained using two-dimensional transvaginal ultrasonography. Monthly colposcopic evaluations were conducted, cervical biopsies were taken at the third month, and a cytological assessment was performed at the sixth month. Cervical volume and length regeneration were calculated and analyzed in relation to the dimensions of the excised cone. Regeneration percentages and their correlations with excised tissue dimensions were evaluated using paired t-tests and Pearson correlation analysis. Results: Mean cervical volume and length regeneration rates at six months were 84.61% ± 5.64 and 86.36% ± 3.33, respectively. The transformation zone was histologically visible in 32.1% of patients at three months and cytologically in 75.9% at six months. An inverse correlation was observed between both cone volume and length and cervical regeneration (p < 0.005). Patients with larger preoperative cervical dimensions exhibited a higher regenerative capacity. Positive surgical margins were found in only one patient (3.4%), and no high-grade cytologic abnormalities were noted at follow-up. Conclusions: MESC may enable substantial cervical regeneration within six months. Larger excisions impair healing and delay transformation zone reformation, which may inform the optimal timing for initiating gynecological and colposcopic examinations, as well as for performing cervical interventions when indicated. Full article

The Zigui Basin, located in the Three Gorges Reservoir Area, has developed numerous landslides due to its interlayering of sandstone and mudstone, geological structure, and reservoir operations. This study identifies a fourth type of landslide failure mode: an oblique-dip slope wedge (OdSW) landslide, based on the Wanshuitian landslide. Following four heavy rainfall events from 3 to 13 July 2024, this landslide exhibited significant deformation on the 17th and was completely destroyed within 40 min. The dimensions of the landslide were 350 m in length, 160 m in width, and 20 m in thickness, with a volume estimated at 8.0 × 10⁵ m³. The characteristics of landslide deformation and the changes in moisture content within the shallow slide body were ascertained using unmanned aerial vehicles, moisture meters, and mobile phone photography. The landslide was identified to have occurred within the weathered residual layer of mudstone, situated between two sandstone layers, with the eastern boundary defined by an inclined rock layer. Upon transitioning into the accelerated deformation stage, the landslide initially exhibited uniform overall sliding deformation, culminating in accelerated deformation destruction. The dip structure created terrain disparities, resulting in a step-like terrain on the left bank and gentler slopes on the right bank, with interbedded soil and rock in a shallow layer, because the interlayered soft and hard geological conditions caused varied weathering and erosion patterns on the riverbank slopes. The interbedded weak–hard stratum layer fostered the development of the oblique-dip slope wedge landslide. Based on the improved Green–Ampt model, we developed a stability prediction methodology for an oblique-dip slope wedge landslide and determined the rainfall infiltration depth threshold of the Wanshuitian landslide (9.8 m). This study aimed not merely to sharpen the evolution mechanism and stability prediction of the Wanshuitian landslide but also to formulate more effective landslide-monitoring strategies and emergency management measures. Full article

Slotted roller buckets are energy dissipator structures designed to reduce the destructive power of high-velocity water flows in spillways, protecting downstream environments. This study aimed to estimate the critical role of slotted roller bucket design in downstream scour mitigation and hydraulic energy dissipation. The three-dimensional Navier–Stokes (N-St) equations were solved to simulate the jet flow over the roller bucket using CFD software. The free surface volume tracking using the volume of fluid (VOF) and non-equilibrium sediment transport equations was coupled with N-St to model the local scour downstream of the roller bucket system. Subsequently, the impact of bucket tooth lip angles, tailwater depth, and bucket radius on downstream scour were examined in a numerical 3D framework. The results showed that the 45- to 55-degree lip angle configuration significantly reduced the maximum scour depth by approximately 36%. Furthermore, the study quantified the effects of tailwater depth and bucket radius on scour dimensions and flow patterns. The optimal tailwater depth reduced scour depth by approximately 20% compared with the worst case, while variations in bucket radius led to more than a 50% difference in scour depth. We identified specific ranges for these parameters that further minimized erosion potential. The research also underscored the influence of transverse mixing on surging depth, revealing a crucial mechanism for energy dissipation. These findings contributed to a deeper understanding of the complex interplay between design parameters and scour. It offered practical insights for optimizing and operating hydraulic structures sustainably and understanding the scouring processes downstream of the dams. Full article

Background: Maxillary sinus floor augmentation (MSFA) is commonly used to increase posterior maxillary bone volume prior to implant placement. Although generally successful, late complications can impact long-term outcomes. The purpose of the study was to estimate the incidence and timing of atypical late complications following (MSFA) using bovine xenohybrid bone grafts. The study also aimed to evaluate whether preoperative bone volume is associated with the risk of complications. Methods: This retrospective cohort study was conducted at the Center of Oral and Maxillofacial Surgery, Danube Private University, Krems-Stein, Austria, and included patients who underwent MSFA with bovine xenohybrid bone grafts and either simultaneous or staged implant placement between January 2020 and December 2023. Preoperative bone volume of the posterior maxilla measured via cone beam computed tomography (CBCT) in the planned implant insertion position. The primary endpoint was the time (days) from MSFA to the occurrence of a graft-related complication (defined as atypical if occurring more than 6 months after MSFA and not related to peri-implantitis) The covariates included subjects’ age, sex, the quantity of graft used for MSFA, timing of dental implant insertion (simultaneous vs. staged) and implant dimensions. Kaplan–Meier analysis and Cox proportional hazards regression were used to evaluate time-to-event data. Only one graft site per patient was analyzed. Results: Atypical complications occurred in 9 out of 47 patients (19.1%), with an average time to onset of 645 days. In a multivariable analysis, a lower preoperative bone volume was found to be an independent predictor of an increased risk of complications (hazard ratio [HR]: 0.972; 95% confidence interval [CI]: 0.925–1.021; p = 0.252). However, the quantity of graft used for MSFA was not found to be a predictor (p = 0.46). Conclusions: Within the limitations of a retrospective study, reduced native bone volume appears to increase the risk of atypical late complications following MSFA with bovine xenohybrid grafts. This makes closer clinical and radiologic follow-up of patients over a longer period very necessary. Full article