Search Results (320)

Indoor environments significantly influence human interaction, collaboration, and well-being, yet evaluating how architectural designs actually perform in fostering social connections remains challenging. This study demonstrates the use of 11 static-mounted lidar sensors to detect serendipitous encounters—collisions—between people in a shared common space of a mixed academic–residential university building. A novel collision detection algorithm achieved 86.1% precision and detected 14,022 interactions over 115 days (67 million person-seconds) of an academic semester. While occupancy strongly predicted collision frequency overall (R² ≥ 0.74), significant spatiotemporal variations revealed the complex relationship between co-presence and social interaction. Key findings include the following: (1) collision frequency peaked early in the semester then declined by ~25% by mid-semester; (2) temporal lags between occupancy and collision peaks of 2–3 h in the afternoon indicate that social interaction differs from physical presence; (3) collisions per occupancy peaked on the weekend, with Saturday showing 52% higher rates than the weekly average; and (4) collisions clustered at key transition zones (elevator areas, stair bases), with an additional “friction effect”, where proximity to seating increased interaction rates (>30%) compared to open corridors. This methodology establishes a scalable framework for post-occupancy evaluation, enabling evidence-based assessment of design effectiveness in fostering the spontaneous interactions essential for creativity, innovation, and place-making in built environments. Full article

Both climate change and human activities have had a significant impact on hydrological processes. Quantification of affecting factors on river regime changes is scientifically essential for understanding hydrological processes and sustainable water resources management in the basins. This study investigates the features of variations in meteorological and hydrological variables in the Liuhe River Basin (LRB) from 1956 to 2020 based on various observed records and statistical methods. It then quantitatively identifies the possible impacts of climate variability and human activities on runoff in the LRB using the empirical methods and the Budyko framework. The results show that (1) the runoff demonstrates a significantly decreasing trend over the past 65 years, but the rainfall has no obvious trend with significant interannual fluctuations, and potential evapotranspiration exhibits a weekly decreasing trend, particularly in summer. (2) The runoff series can be divided into two periods, i.e., the baseline (1956–1969) and change (1970–2020) periods, and the change period can also be divided into two stages, i.e., stage I (1970–1999) and stage II (2000–2020). (3) Human activities are the dominant factors in the runoff decline in the LRB, with the contribution rates being greater than 80% in the change period, particularly for stage II. The analysis of this study can provide a reference for the rational utilization of water resources in the LRB. Full article

This cross-sectional study evaluates the potential spatial accessibility of primary percutaneous coronary intervention (pPCI) facilities in the Republic of Serbia (RS) for the year 2030. Cardiovascular diseases, specifically acute myocardial infarction (AMI), are major contributors to mortality, requiring immediate intervention to reestablish blood circulation to the heart. This research employs travel time isochrone analysis to assess the percentage of the population residing within three specific time intervals (30, 60, and 90 min) from a pPCI facility. We project the percentage of the population residing within a 30 min travel time interval to be 50% in 2030. Additionally, the percentage of the population residing within the 90 min travel time interval from a pPCI facility, i.e., known as the “golden hour” travel time distance, is around 96%, with some weekly variations that equate to 1%. We utilized additional spatial analysis to identify population clusters that reside beyond the 90 min travel time from a pPCI facility. These results point to specific regions where either additional pPCI facilities or better road connections would most effectively reduce treatment delays. Additionally, the study highlighted the optimal location for a novel pPCI facility, which is the city of Vršac. Our findings underline the need for careful planning in the health system, where location and transport data can directly guide measures to improve access and lower cardiovascular disease (CVD) mortality. Full article

This study explores how the integration of generative artificial intelligence, multi-objective evolutionary optimization, and reinforcement learning can enable sustainable and cost-effective decision-making in supply chain strategy. Using real-world retail demand data enriched with synthetic sustainability attributes, we trained a Variational Autoencoder (VAE) to generate plausible future demand scenarios. These were used to seed a Non-Dominated Sorting Genetic Algorithm (NSGA-II) aimed at identifying Pareto-optimal sourcing strategies that balance delivery cost and CO₂ emissions. The resulting Pareto frontier revealed favorable trade-offs, enabling up to 50% emission reductions for only a 10–15% cost increase. We further deployed a deep Q-learning (DQN) agent to dynamically manage weekly shipments under a selected balanced strategy. The reinforcement learning policy achieved an additional 10% emission reduction by adaptively switching between green and conventional transport modes in response to demand and carbon pricing. Importantly, the agent also demonstrated resilience during simulated supply disruptions by rerouting decisions in real time. This research contributes a novel AI-based decision architecture that combines generative modeling, evolutionary search, and adaptive control to support sustainability in complex and uncertain supply chains. Full article

This study proposes a hybrid forecasting framework that integrates the Auto-Regressive Integrated Moving Average (ARIMA) model with multiple variations of the Ata model, using a performance-based model selection strategy to enhance forecasting accuracy on the M3 and M4 competition datasets. For each time series, seven versions of the Ata model are generated by adjusting level and trend parameters, and the version with the lowest in-sample symmetric mean absolute percentage error (sMAPE) is selected. To improve robustness and prevent overfitting, the median-performing Ata model is also included. These selected models’ forecasts are then combined with ARIMA outputs through optimized weighting schemes tailored to the characteristics of each series. Given the varying frequencies (e.g., yearly, quarterly, monthly, weekly, daily, and hourly) and diverse lengths of time series, a grid search algorithm is employed to determine the best hybrid combination for each frequency group. The model is applied in a series-specific manner, allowing it to adapt to different seasonal, trend, and irregular patterns. Extensive empirical results demonstrate that the hybrid model outperforms its individual components and traditional benchmarks across all frequency categories. It ranked first in the M3 competition and achieved second place in the M4 competition based on the official error metric, the sMAPE and Overall Weighted Average (OWA), respectively. The results highlight the framework’s adaptability and scalability for complex, heterogeneous time series environments. Full article

Based on fundamental mechanics, movement and force associate head and pelvic movement asymmetry with asymmetry of force production. We investigate, how often racehorses undergoing strenuous training regimens show evidence of switching between “preferred” limbs, i.e. one limb producing increased force, when assessed at monthly intervals? We hypothesize that clinical asymmetry thresholds designed for “detecting lameness” are frequently exceeded and that when applying previously established Thoroughbred-specific repeatability values, horses rarely switch between showing left- and right-sided asymmetry. Monthly gait assessments (inertial sensors) were conducted in 256 Thoroughbred racehorses at least twice per horse (up to 16 times per horse). Descriptive statistics for absolute differences for head and pelvic movement were compared to published Thoroughbred-specific repeatability values. The percentage of left–right switches between repeat assessments was calculated in comparison to three different levels of pre-defined thresholds (perfect symmetry, clinical lameness thresholds, previously established Thoroughbred-specific repeatability values) and switch frequencies compared between the three thresholds. Ranges containing 95% of monthly differences were higher than published daily and weekly values except for pelvic vertical range of motion. Approximately 30% of monthly differences in individual symmetry parameters showed left–right switches around “perfect symmetry”. Utilizing clinical lameness thresholds for categorizing left–right switches, a significantly (p < 0.001) reduced percentage of 4–11% of measurements for head movement and 7–17% for pelvic movement showed switches. Using daily repeatability values for categorization, a further significantly (p < 0.001) reduced percentage of switches was observed: 0.3–3.6% for head movement and 0.6–7.0% for pelvic movement. While racehorses in training regularly switch between small left- or right-sided movement symmetries, they less frequently switch between more pronounced left- and right-sided movement symmetries defined based on daily variations. Further studies should investigate the reasons for these rare switches. Full article

Objectives: This study aimed to assess the precision of dose delivery to the target in adaptive carbon ion radiotherapy (CIRT) for locally advanced non-small cell lung cancer (LA-NSCLC) in cumulative dosimetry. Methods: Forty-six patients who received CIRT were included (64 Gy[relative biological effectiveness, RBE] in 16 fractions) with treatment plan computed tomography (CT) and weekly CT scans. Offline adaptive radiotherapy (ART) was administered if the dose distribution significantly worsened. Daily doses were calculated from weekly CTs and integrated into plan CT scans using deformable image registration. The dosimetry parameters were compared between the as-scheduled plan and adaptive replan in patients receiving ART. Survival outcomes and toxicity were compared between the ART and non-ART groups. Results: ART was implemented for 27 patients in whom adaptive replans significantly increased the median V_98% of the clinical tumor volume from 96.5% to 98.1% and D_98% from 60.5 to 62.7 Gy(RBE) compared with the as-scheduled plans (p < 0.001). The conformity and uniformity of the dose distribution improved (p < 0.001), with no significant differences in the doses to normal tissues (lungs, heart, esophagus, and spinal cord) from the as-scheduled plans (p > 0.05). The ART and non-ART groups demonstrated comparable local control, progression-free survival, and overall survival (p > 0.05). No grade 3 or higher radiation-related toxicities were observed. Conclusions: ART enhanced target dose coverage while maintaining acceptable normal tissue exposure, supporting weekly CT monitoring integration during CIRT for the timely intervention for anatomical variations, ensuring precise dose delivery in LA-NSCLC. Full article

The effects of precision feeding regimes on broiler performance, organ weight, nutrient utilization, carcass yield, and calculated wholesale returns were investigated over 42 days. The treatments consisted of a standard four-phase commercial diet as the control, a precision nutrition blend diet based on a daily nutrient requirement, a precision nutrition adjusted diet based on weekly bird weight, and a standard commercial blend diet. Each dietary treatment was replicated 10 times with 11 birds per replicate. A total of 440 male Ross 308 (Aviagen, Goulburn, NSW, Australia) broiler chickens were offered experimental diets from days 11 to 42 post-hatch. Dietary treatments did not affect the feed intake and weight gain over the entire study. However, a reduced weight corrected FCR (higher feed efficiency) was observed in birds fed a precision nutrition adjusted blend diet compared to those fed the control diet from days 11 to 42 (p < 0.001). There were no significant differences in feed costs between treatments. Birds offered the precision nutrition adjusted diet improved AME (p = 0.002) measured from days 25 to 27 compared to the blended standard diet. Over the majority of time points, the precision nutrition adjusted diet significantly reduced the coefficient of variation in bird weight as compared to the control diet (p < 0.026). Full article

Carbon isotope fractionation is an efficient tool used for the discrimination and differentiation of sinks and emission sources. Carbon dioxide (CO₂) and methane (CH₄) are among the key drivers of climate change, and a detailed evaluation of variations in the ¹³C/¹²C ratio in either compound provides vital information for the field of atmospheric sciences. The Italian atmospheric ICOS (Integrated Carbon Observation System) consortium is currently implementing δ¹³C-CO₂ and δ¹³C-CH₄ measurements, with four observation sites now equipped with Picarro G2201-i CRDS (Cavity Ring-Down Spectrometry) analyzers. In this work, results from the first two months of measurements performed at the Potenza station in southern Italy between 20 February and 20 April 2025 are presented and constitute the first evaluation of continuous atmospheric δ¹³C-CO₂ and δ¹³C-CH₄ measurements from an Italian station. These results provide a first insight on how these measurements can improve the current understanding of CO₂ and CH₄ variability in the Italian peninsula and the central Mediterranean sector. Although preliminary in nature, the findings of these measurements indicate that fossil fuel burning is responsible for the observed peaks in CO₂ concentrations. CH₄ has a generally stable pattern; however, abrupt peaks in its isotopic delta, observed during March, may constitute the first direct evidence in Italy of Saharan dust intrusion affecting carbon isotope fractionation in the atmosphere. This study also introduces an analysis of the weekly behavior in isotopic deltas. Full article

Introduction: The main purpose of this study was to test a hierarchical model of motivation that integrates Achievement Goal Theory and Self-Determination Theory to explain and predict exercise adherence. Method: In total, 2180 exercisers (1020 female, 1160 male) aged between 18 and 60 years, from different gyms and health clubs, completed several scales validated in exercise settings, regarding perceived motivational climate, basic psychological need satisfaction, behavioral regulation, and exercise adherence. For the last measure, weekly computer access to a control system over a 6-month period before and after data collection was consulted. Results: Through structural equation models (SEM), it was verified that (1) task-involving climate positively predicted basic psychological needs. In turn, the satisfaction of these needs predicted autonomous motivation, which led to a positive prediction of adherence; (2) a small variation in exercise adherence was explained by the motivational model under analysis. Nevertheless, models significantly improved their analytical power when past adherence was inserted in the model increasing the explained variance in future behavior from 9.2% to 64%. Conclusions: In conclusion, autonomous motivation can predict people’s exercise adherence, and past behavior increases that predictive effect. The present study brings scientific evidence to the popular saying “tell me what you’ve done and, and I’ll predict what you’ll do”. Full article

On-farm emergency slaughter (OFES) is employed when cattle are unfit for transport but still suitable for human consumption, thereby ensuring animal welfare and reducing food waste. This study analysed OFES patterns in Northern Italy, where a large cattle population is housed but information on the practice is rarely analysed. A total of 12,052 OFES cases from 2021 to 2023 were analysed. Most involved female cattle (94%) from dairy farms (79%). Locomotor disorders were the leading reason (70%), particularly trauma and fractures, followed by recumbency (13%) and calving-related issues (10%). Post-mortem findings showed limbs and joints as the most frequent condemnation sites (36%), often linked to trauma. A significant reduction in OFES cases occurred over time, mainly due to fewer recumbency and calving issues, likely reflecting stricter eligibility criteria introduced in 2022. Weekly variations, with peaks on Mondays and lows on Saturdays, suggest that logistical constraints may sometimes influence OFES promptness. These findings suggest that on-farm management and animal handling could be improved further to reduce welfare risks and carcass waste. Due to the lack of standardised data collection and regulatory harmonisation, a multi-country investigation could improve our understanding of this topic and inform best practice. Full article

Background/Objectives: Recent studies linked a diet rich in ultra-processed foods (UPFs) with depression and diabetes. Although common risk factors, such as aging, are defined for both diseases, how UPFs are associated with the bidirectional relationship between them is not known. This study aimed to investigate whether UPF intake modifies the association between depression and diabetes within the Brazilian adult population. Methods: This cross-sectional analysis utilized data from the 2019 Brazilian National Health Survey, involving over 87,000 adults (aged 18–92 years). Participants provided self-reported data on diabetes and depression diagnoses, dietary habits (assessed by qualitative FFQ), as well as demographic, and socioeconomic variables. Multivariate logistic regression models were used to evaluate the associations, employing two classification methods—UPF1 and UPF2—based on different thresholds of weekly consumption, for high/low UPF intake. Analyses were stratified by age groups to identify variations in associations. Results: There was a significant association between depression and diabetes, especially among participants with high UPF consumption. Models adjusted by demographic characteristics, as well as meat and vegetable consumptions, demonstrated elevated odds ratios (ORs) for diabetes among individuals with depression consuming high levels of UPF, compared to those with a low UPF intake (OR: 1.258; 95% CI: 1.064–1.489 for UPF1 and OR: 1.251; 95% CI: 1.059–1.478 for UPF2). Stratified analysis by age further amplified these findings, with younger individuals showing notably stronger associations (non-old adult group OR: 1.596; 95% CI: 1.127–2.260 for UPF1, and OR: 6.726; 95% CI: 2.625–17.233 for UPF2). Conclusions: These findings suggest that high UPF intake may influence the relationship between depression and diabetes, especially in younger adults. Future longitudinal studies are warranted to establish causality, investigate underlying biological mechanisms, and examine whether improving overall nutrient intake through dietary interventions can reduce the co-occurrence of depression and diabetes. Full article

Myofascial pain syndrome (MPS) is caused by trigger points (TrPs): hypersensitive spots in taut muscle bands that impair function and cause pain. Dry needling (DN) is a common treatment in humans, but evidence in horses is limited. This prospective, controlled study evaluated the effectiveness of DN in reducing TrP-related pain in the brachiocephalic muscle of horses. Of the 98 horses enrolled, 66 were allocated to a treatment group receiving weekly DN sessions for three weeks, while 32 were assigned to a control group with no intervention. Pain and function were assessed using pressure algometry, a numerical rating scale (NRS), a functional total test score (FTTS), and behavioral indicators including jump sign (JS), equine pain face (EPF), and local twitch responses (LTRs). Assessments were performed at baseline and at 0, 4, 24, and 72 h post-intervention. Results indicate a significant increase in pressure pain thresholds (p < 0.001), especially after the second and third sessions. Both NRS and FTTS improved significantly over time (p < 0.001), and LTRs progressively decreased. EPF and JS showed minimal variation. These results support the use of DN to reduce local muscle pain and improve function in horses with TrPs. Further robust studies are warranted to refine protocols and investigate long-term effects. Full article

This study investigated the seasonal and spatial dynamics of off-flavour compounds—geosmin and 2-methylisoborneol (2-MIB)—in an intensive rainbow trout (Oncorhynchus mykiss) aquaculture system for human consumption in western Spain. Weekly water and fish flesh samples were collected over a 12-month period from three farms supplied by the River Tormes. Physicochemical parameters, determination of geosmin and 2-MIB by SPME-GC-MS, microbial counts, and microbial community composition were assessed alongside volatile compound concentrations. Geosmin and 2-MIB showed marked seasonal variation, with peak levels in water and fish flesh during spring and summer, correlating positively with temperature. Geosmin accumulation in fish was highest in the downstream farm, suggesting cumulative exposure effects. In contrast, 2-MIB was detected only in water and at lower concentrations. Microbial analyses revealed high bacterial and fungal diversity, including cyanobacterial taxa such as Phormidium setchellianum and Pseudoanabaena minima, known producers of geosmin and 2-MIB. These findings highlight the importance of water microbiota and environmental conditions in off-flavour development. Managing cyanobacterial populations and monitoring spatial-temporal variability are essential to mitigate the development of earthy or musty flavours and economic losses in aquaculture systems. Full article

Using a segmented linear regression model, we examined the seasonal profiles of weekly COVID-19 deaths data in Italy over a three-year-long period during which the SARS-CoV-2 Omicron and post-Omicron variants were predominant (September 2021–September 2024). Comparing the slopes of the regression segments, we were able to discuss the variation in steepness of the Italian COVID-19 mortality trend, identifying the corresponding growth/decline profile for each considered season. Our findings show that, although the COVID-19 weekly death mortality has been in a declining trend in Italy since the end of 2021 until the end of 2024, there have been increasing alterations in the COVID-19 deaths for all winters and summers of that period. These increasing mortality variations were more pronounced in winters than in summers, with an average progressive increase in the number of COVID-19 deaths, with each new week, of 55.75 and 22.90, in winters and in summers, respectively. We found that COVID-19 deaths were, instead, less frequent in the intermediate periods between winters and summers, with an average decrease of −38.01 COVID-19 deaths for each new week. Our segmented regression model has fitted well the observed COVID-19 deaths, as confirmed by the average value of the determination coefficients: 0.74, 0.63 and 0.70, respectively, for winters, summers and intermediate periods. In conclusion, favored by a general declining COVID-19 mortality trend in Italy in the period of interest, transient rises of the mortality have occurred both in winters and in summers, but received little attention because they have always been compensated by consistent downward drifts occurring during the intermediate periods between winters and summers. Full article