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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic. The journal’s Editor-in-Chief and/or designated EBM will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Exploring Signaling, Cellular and Molecular Plant Defense against Viruses submission deadline 30 May 2024 | 1 articles | Viewed by 740 | Submission Open
Keywords: plant viruses; cellular and molecular host response; resistance; plant– virus interaction; innate immunity; microscopy; plant defense systems; signal transduction
(This special issue belongs to the Section Molecular Plant Sciences)
Plasticity of the Nervous System after Injury 2.0 submission deadline 30 May 2024 | 1 articles | Viewed by 716 | Submission Open
Keywords: neural plasticity; axonal regeneration; nerve injury; glial cells; central nervous system
(This special issue belongs to the Section Molecular Neurobiology)
Natural-Sourced Compounds: Chemical Composition, Biological Activity and Toxicity Assessment
edited by and Faouzi Errachidi
submission deadline 30 May 2024 | Viewed by 700 | Submission Open
Keywords: natural-sourced compounds; marine resources; chemical composition; biological activity; antimicrobial; antioxidant; green extraction methods; toxicity assessment
(This special issue belongs to the Section Molecular Toxicology)
Recent Studies on Biological Activities of Alkaloids and Their Modifications
edited by
submission deadline 30 May 2024 | 1 articles | Viewed by 695 | Submission Open
Keywords: alkaloids; chemical modification; biological activity
(This special issue belongs to the Section Biochemistry)
Hepatitis Viruses and Hepatocellular Carcinoma: Research, Treatment and Challenges
edited by
submission deadline 30 May 2024 | Viewed by 646 | Submission Open
Keywords: HBV; HDV; HCV; virus replication and pathogenesis; antivirals; virus– cell interaction; vaccine development; hepatocellular carcinoma
(This special issue belongs to the Section Molecular Immunology)
Molecular Docking, Interaction and Mechanism of Action of Bioactive Peptides
edited by
submission deadline 30 May 2024 | 1 articles | Viewed by 638 | Submission Open
Keywords: bioactive peptides; molecular docking; molecular dynamics simulations; computer-aided screening; structure– activity relationship; bioavailability; bioinformatics
(This special issue belongs to the Section Molecular Informatics)
Health, Disease, and Chronobiology: Molecular and Genetics Aspects submission deadline 30 May 2024 | Viewed by 635 | Submission Open
Keywords: chronobiology; timing of food; sleep; time-restricted eating; metabolism; genomics; epigenomics; metabolomics; microbiome; mechanisms
(This special issue belongs to the Section Molecular Biology)
Nanotechnology in the Treatment and Diagnosis of Cancer: Opportunities and Challenges
edited by Lucyna Kapka-Skrzypczak
submission deadline 30 May 2024 | 1 articles | Viewed by 547 | Submission Open
Keywords: nanomaterials; cancer; nanomedicine; biological effects; cancer therapy; metastasis
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Mechanism and Treatment of Allergic Asthma
edited by and Marcello Cottini
submission deadline 30 May 2024 | 1 articles | Viewed by 525 | Submission Open
Keywords: allergic asthma; epithelial barrier damage; protease allergen; type 2 inflammation
(This special issue belongs to the Section Molecular Immunology)
Advances in Electrochemistry of Metal Nanomaterials
edited by Evangelina Pensa, Miriam C. Rodríguez González and Maria Pilar Carro Reglero
submission deadline 30 May 2024 | Viewed by 510 | Submission Open
Keywords: metal nanomaterials; electrochemistry; electrocatalysis; charge storage capabilities; electron transfer kinetics
(This special issue belongs to the Section Molecular Nanoscience)
Drought Stress Tolerance in Plants in 2024
edited by
submission deadline 30 May 2024 | 1 articles | Viewed by 509 | Submission Open
Keywords: root physiology; drought tolerance; photosynthesis; water deficit stress; shoot– root interaction; salinity; crop plants
(This special issue belongs to the Section Molecular Plant Sciences)
Pathogenetic Factors of Ophthalmological Symptoms in Systemic Diseases submission deadline 30 May 2024 | 1 articles | Viewed by 467 | Submission Open
Keywords: diagnosis; uveitis; keratitis; ocular inflammation; hypersensitivity
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Molecular Insights into Antimicrobial Photo-Treatments
edited by Pietro Delcanale
submission deadline 30 May 2024 | 1 articles | Viewed by 418 | Submission Open
Keywords: photodynamic inactivation; photo-thermal therapy; photosensitization; antimicrobials; reactive oxygen species; photo-treatments; antibiotic resistance; singlet oxygen; antivirals
(This special issue belongs to the Section Molecular Microbiology)
Crosstalk between Lipids and Immunity
edited by
submission deadline 30 May 2024 | Viewed by 408 | Submission Open
Keywords: eicosanoids; sphingolipids; endocannabionoids; specialized pro-resolving mediators; lysophospholipids; lipidomics; membrane-lipids therapy
(This special issue belongs to the Section Molecular Immunology)
Molecular Insight into Dentistry and Craniofacial Surgery: Celebrating the 110th Anniversary of Dentistry in Italy
edited by
submission deadline 30 May 2024 | Viewed by 379 | Submission Open
Keywords: dentistry; craniofacial district; technological; oral health; molecular research; materials; restorative dentistry; prosthodontics; oral surgery; implantology; pediatric dentistry; orthodontics; temporomandibular disorder
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Zinc Enzymes for Drug Design and Drug Development submission deadline 30 May 2024 | Viewed by 336 | Submission Open
Keywords: zinc enzymes; carbonic anhydrases; matrix metalloproteinases; histone deacetylases; zinc metalloenzymes; drug design
(This special issue belongs to the Section Molecular Pharmacology)
Nanocomposites Based on Graphite and Its Derivatives for Cutting-Edge Applications submission deadline 30 May 2024 | Viewed by 332 | Submission Open
Keywords: nanostructures; graphene nanocomposites; sustainable procedures; electrodes; thin films; sensors; photocatalysis; energy conversion; energy storage
(This special issue belongs to the Section Molecular Nanoscience)
Nutrient Sensing in Human Metabolic Diseases: Associated Molecular Mechanisms submission deadline 30 May 2024 | Viewed by 331 | Submission Open
Keywords: nutrition; functional food; bioactive compounds; gene; nutrigenomics; nutrigenetics; metabolomics; proteomics; microbiota; chronic diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Immune Modulation of Macrophages 2.0
edited by and Yan Chen
submission deadline 30 May 2024 | Viewed by 323 | Submission Open
Keywords: macrophages; treatment; phenotype change; pathway analysis
(This special issue belongs to the Section Molecular Immunology)
RNA-Seq in Human Health and Disease
edited by
submission deadline 30 May 2024 | Viewed by 303 | Submission Open
Keywords: aging; bioinformatics; single-cell RNA-Seq; RNA-Seq
(This special issue belongs to the Section Molecular Informatics)
Brain Metastasis 2024
edited by
submission deadline 30 May 2024 | Viewed by 298 | Submission Open
Keywords: brain metastasis; brain microenvironment; pathology; circulating tumor cells; tumor-normal cell crosstalks; new biomarkers and therapies for brain metastasis; cerebral spinal fluid/liquid biopsy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Type 2 Diabetes and Its Complications
edited by
submission deadline 30 May 2024 | Viewed by 290 | Submission Open
Keywords: diabetes; metabolic defects; β -cell function; dietary intervention; physical exercise
(This special issue belongs to the Section Molecular Biology)
Gene Therapy in Neuropathy
edited by
submission deadline 30 May 2024 | Viewed by 289 | Submission Open
Keywords: gene therapy; adeno-associated viral vectors; lentiviral vectors; nanoparticles; antisense oligonucleotides; CRISPR Cas9; RNA; CNS; PNS
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Mechanisms of Musculoskeletal Involvement in Rare Diseases
edited by
submission deadline 30 May 2024 | Viewed by 277 | Submission Open
Keywords: rare diseases; molecular pathways; musculoskeletal system; bone involvement; joint degeneration
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular and Cellular Mechanisms of Gynecologic Malignancies, Benign Diseases 2.0
edited by
submission deadline 30 May 2024 | Viewed by 272 | Submission Open
Keywords: gynecologic malignancies; endometrial cancer; ovarian cancer; cervical cancer; uterine cancer; chemotherapy; target therapy; tumor marker; benign gynecologic diseases; endometriosis; polycystic ovary syndrome
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular and Electrophysiological Modulation in Cardiac Arrhythmias
edited by
submission deadline 30 May 2024 | Viewed by 263 | Submission Open
Keywords: arrhythmias; cardiac electrophysiology; molecular biology; ion channels; intracellular regulation; intracellular calcium dynamics; trafficking; post-translational modifications; structural alterations; gene expression; animal models; basic; translational and clinical science
(This special issue belongs to the Section Molecular Biology)
Advanced Glycoproteomics Research
edited by
submission deadline 30 May 2024 | Viewed by 262 | Submission Open
Keywords: glycosylation; glycoproteomics; site-specific glycan structures; glycan function; biochemical validation
(This special issue belongs to the Section Biochemistry)
Molecular Mechanisms in Dry Eye Disease: Effects on Pathogenesis, Treatment and Ocular Surgery
edited by
submission deadline 30 May 2024 | Viewed by 257 | Submission Open
Keywords: dry eye disease; molecular mechanisms pathophysiology; pathogenesis; treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cytokine Signaling in Development, Homeostasis and Disease
edited by
submission deadline 30 May 2024 | Viewed by 254 | Submission Open
Keywords: cytokine signaling; development; homeostasis; disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Osteoarthritis Biomarkers, Diagnosis and Treatments
edited by
submission deadline 30 May 2024 | 1 articles | Viewed by 253 | Submission Open
Keywords: osteoarthritis; degenerative joint disease; biomarkers; diagnosis; treatments
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Primary Cell Line Models in Evolutionary Molecular Physiology
edited by
submission deadline 30 May 2024 | Viewed by 252 | Submission Open
Keywords: cell physiology; fibroblasts; comparative biology; evolution; physiological ecology; vertebrates; primary cell line
(This special issue belongs to the Section Molecular Biology)
Plant Bioactive Compounds: Antioxidant, Anti-inflammatory and Anticancer Effects submission deadline 30 May 2024 | Viewed by 224 | Submission Open
Keywords: anticancer; antioxidant; anti-inflammatory; bioactive compounds; chemical biology; molecular biology; metabolic diseases; nutrition.
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Role of Steroids and Triterpenoids in Plant Growth, Development and Stress Response 2.0
edited by
submission deadline 30 May 2024 | Viewed by 215 | Submission Open
Keywords: biosynthesis; chemical defense; plant growth and development; steroids; sterols; stress response; triterpenoids
(This special issue belongs to the Section Molecular Plant Sciences)
Research Advances in Whole-Genome/Exome Sequencing (WGS/WES) and Next-Generation Sequencing
edited by
submission deadline 30 May 2024 | Viewed by 209 | Submission Open
Keywords: short/long-read sequencing; whole-exome sequencing; whole-genome sequencing; bioinformatics; variant classification models; translational medicine
(This special issue belongs to the Section Molecular Genetics and Genomics)
The Dynamics of Redox Metabolism in Plants submission deadline 30 May 2024 | Viewed by 206 | Submission Open
Keywords: plant metabolism; plant stress; post-translational modifications; reactive oxygen/nitrogen/sulfur species; redox regulation; signaling
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Advances in Blood–Brain Barrier, Blood–Cerebrospinal Fluid Barrier and Cerebrospinal Fluid–Brain Barriers submission deadline 30 May 2024 | Viewed by 202 | Submission Open
Keywords: blood– brain barrier (BBB); blood– cerebrospinal fluid (CSF) barrier (BCSFB); CSF– brain barriers (CSFBB); brain homeostasis; neuroscience; depression; multiple sclerosis; stroke
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural-Derived Nanocarriers as Delivery Systems for Biomolecules
edited by
submission deadline 30 May 2024 | Viewed by 195 | Submission Open
Keywords: natural nanocarriers; biomolecules; delivery systems; nanomedicine; human health; controlled release
(This special issue belongs to the Section Molecular Biology)
Model Organisms in Plant Science: Metal Transport in Tomato
edited by
submission deadline 30 May 2024 | Viewed by 186 | Submission Open
Keywords: metal; uptake; translocation; sequestration; transmembrane transport
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Computational Modelling in the Context of Safe and Sustainability-by-Design Strategy
edited by Alicja Mikołajczyk
submission deadline 30 May 2024 | Viewed by 184 | Submission Open
Keywords: molecular informatics; molecular computational modelling; materials modeling; molecular study; chemoinformatic design
(This special issue belongs to the Section Molecular Informatics)
Advances in Molecular Research of Diabetic Cardiomyopathy submission deadline 30 May 2024 | Viewed by 180 | Submission Open
Keywords: diabetic cardiomyopathy; apoptosis; diabetes; myocardial fibrosis; stem cells; inflammation; therapeutic approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Circadian Biology in Human Health and Disease
edited by Flore Sinturel
submission deadline 30 May 2024 | Viewed by 180 | Submission Open
Keywords: circadian rhythms; metabolism; misalignment; synchronization; molecular clock; internal body clocks; sleep– wake cycle
(This special issue belongs to the Section Molecular Biology)
Editorial Board Members’ Collection Series: Chemical Molecular Structure, Function and Reactions submission deadline 30 May 2024 | Viewed by 176 | Submission Open
Keywords: chemical molecules; chemical reactions; molecules interations; molecules structure; molecular dynamics
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Bioactive Materials with Antimicrobial Properties 2.0 submission deadline 30 May 2024 | Viewed by 174 | Submission Open
Keywords: bioactivity; biomedical application; smart packaging; aerospace; textile; antimicrobic activity; antifungal activity
(This special issue belongs to the Section Molecular Microbiology)
The Powerhouse: Mitochondria in Health and Disease
edited by
submission deadline 30 May 2024 | Viewed by 173 | Submission Open
Keywords: mitochondria; targeted therapies; metabolism; ROS; bioenergetics; disease
(This special issue belongs to the Section Molecular Biology)
Advances in the Research of Alzheimer’s Disease and Dietary Neuroprotective Agents submission deadline 30 May 2024 | Viewed by 169 | Submission Open
Keywords: neurodegenerative disorders; brain health; brain– gut-microbiome axis; blood– brain barrier assays; anti-inflammatory activity; antichlolinergic activity; antioxidant activity; bioactive phytochemicals; mechanisms of neuroprotection; brain foods; neuroprotection
(This special issue belongs to the Section Molecular Neurobiology)
Drug Resistance Mechanisms in Human Cancer Cells to Anticancer Drugs
edited by
submission deadline 30 May 2024 | Viewed by 151 | Submission Open
Keywords: cancer therapy; targeted therapy; combination therapy; drug resistance; resensitization; DNA repair; DNA damage response; DNA repair inhibitors; synthetic lethality; chemoradiation
(This special issue belongs to the Section Molecular Pharmacology)
Mechanistic Studies of Mitosis
edited by Eleni Petsalaki
submission deadline 30 May 2024 | Viewed by 151 | Submission Open
Keywords: mitosis; cancer; cell biology; spindle checkpoint; abscission; abscission checkpoint; cytokinesis
(This special issue belongs to the Section Biochemistry)
Advanced Research on Obesity and Cancer
edited by
submission deadline 30 May 2024 | Viewed by 150 | Submission Open
Keywords: obesity; body fat; cancer; adipokines; leptin; adiponectin; angiogenesis; molecular activity; signaling pathways
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms and Therapeutic Advances in Brain Metastasis
edited by Malcolm Lim
submission deadline 30 May 2024 | Viewed by 146 | Submission Open
Keywords: brain metastasis; brain microenvironment; neurotransmitters co-option; blood-tumour barrier; cancer drug delivery; targeted radiotherapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Anti-hypoxia and Oxygenation Agents for Cancer Immunotherapy
edited by Stephen M. Hatfield and Bruce D. Spiess
submission deadline 30 May 2024 | Viewed by 135 | Submission Open
Keywords: oxygenation agents; blood substitutes; immune checkpoint inhibitors; cancer immunotherapies; target tumor hypoxia; hypoxia-targeting prodrugs; perfluorocarbons; injectable oxygen microparticles
(This special issue belongs to the Section Molecular Pharmacology)
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