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Article

Reactions of 9-Alkyl-3-aminocarbazoles with Ethyl-3-oxo-butanoate and Identification of the Products Obtained

by
Birute Sapijanskaite
1,
Ytautas Mickevicius
1 and
Gema Mikulskiene
2,*
1
Department of Organic Chemistry, Kaunas University of Technology, Radvilenu pl. 19, LT-50254 Kaunas, Lithuania
2
Institute of Biochemistry, LT-08662 Vilnius, Mokslininku 12, Lithuania
*
Author to whom correspondence should be addressed.
Molecules 2006, 11(1), 72-80; https://doi.org/10.3390/11010072
Submission received: 17 March 2005 / Revised: 19 October 2005 / Accepted: 20 October 2005 / Published: 31 January 2006
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Versions Notes

Abstract

:
The reactions in benzene of 9-alkyl-3-aminocarbazoles with ethyl-3-oxobutanoate yielded ethyl-3-[(9-alkyl-9H-carbazol-3-yl)amino]but-2-enoate condensation products or N-(9-ethyl-9H-carbazol-3-yl)-3-oxobutanamide acylation products. The condensation products were cyclized to the corresponding 4,7-dihydro-pyrido[2,3-c]-carbazol-1-ones upon heating in mineral oil at 240-250 °C. The structures of the synthesized compounds were investigated by IR, mass spectrometry, 1H- and 13C-NMR spectroscopy and MM2 molecular mechanics and AM1 semi-empirical quantum mechanical methods.

Introduction

We have chosen to study the synthesis of carbazole ring-containing amino acids and their derivatives for two main reasons: carbazole fragments are present in the structure of some alkaloids [1,2,3] and carbazole ring-containing compounds usually exhibit semiconductor properties and are used in electrography [4,5]. It was also expected that their combination with amino acid fragments would enable the synthesis of new biologically active substances.
The goal of this study was to clear up the peculiarities of the synthesis procedure and to investigate the structural features of products obtained. It is known that in the reaction of aromatic amines with ethyl-3-oxobutanoate two types of products can form: amides and condensation products – ethyl-β-arylaminocrotonates [6], and that the direction of the reaction depends on the temperature and catalyst.

Results and Discussion

Reaction of 3-amino-9-ethylcarbazole (1b) with ethyl-3-oxobutanoate in refluxing toluene provided only the acylation reaction product - N-(9-ethylcarbazol-3-yl)-3-oxobutanamide (3, Scheme 1). Addition of a catalytic amount of hydrochloric acid to the reaction solution led to the formation of a mixture of two products – the amide 3 and the condensation product ethyl-3-[(9-ethylcarbazol-3-yl)amino]-2-butenoate (2b) in a 1:4 ratio. Pure condensation products 2a-c were obtained by reaction of amines 1a-c with ethyl-3-oxobutanoate in refluxing benzene in the presence of a catalytic amount of hydrochloric acid with azeotropic separation of the water formed.
Intramolecular cyclizations of compounds 2a-c were carried out in mineral oil at 240-250°C. The reaction according to the synthesis methods of described in literature [7] took 15-20 min, giving compounds 4a-c in quite moderate yields of 46-69%. Prolonged reaction times led to decreased yields of the products.
1H-, 13C-NMR spectra and INEPT 13C-NMR experiments proved the structure of the compounds obtained. The assignment of the resonances in the NMR spectra was based on chemical shift theory [8,9] and signal intensity arguments, multiplicities and comparison with structurally related compounds [10,11,12,13,14,15,16]. The carbon atoms are identified following the arbitrary numbering given in Scheme 1. The results of NMR studies are presented in Table 1.
The spectral lines intrinsic to the carbazolyl and butenoate fragment have been observed in the 13C-NMR spectra of compounds 2a-c. Changes of solvent and the 9N-substituents in the carbazolyl moiety resulted in weak changes of the chemical shifts of carbon resonances, therefore the structural features of the side chain were studied in more detail. The chemical shifts of the double bond of the butenoate moiety were successfully calculated using the additivity rules of substituent influence on the double bond. It was noticed that the double bond in compounds 2a-c is quite polarized due to the different electronic effects of the substituents present [8,9]. The C-11 atom of the double bond adjacent to the NHR group is strongly deshielded and resonates approximately at 160 ppm. The signal of the C-12 atom of the double bond adjacent to the COOCH2CH3 group is observed much further upfield – approximately at 84 ppm.
Compound 3 is distinguished by the characteristic fragments of the side chain moiety, which were specifically reflected in its 13C-NMR spectra. The resonances of the aliphatic carbons of the COCH3 and COCH2CO fragments and the resonances of both CO group carbons in the downfield region reliably confirmed the formation of compound 3.
Molecules 11 00072 g002 550
Scheme 1.
Scheme 1.
Molecules 11 00072 g002
Compounds 4a-c were obtained by cyclization of the butenoate fragment. Particular attention was paid to the structure determination of the cyclization products. The 13C-NMR spectra of compounds 4a-c were assigned on the basis of the model spectrum of 2-methyl-4-quinolone [17]. The respective changes to the spectral information of this compound using the chemical shift additivity rules enabled us to evaluate the chemical shifts of the carbons of the formed ring and its influence on carbazolyl fragment moiety, which is adjacent to the newly formed cycle. The C-11 atom of the double bond adjacent to the NH group in the cyclic compounds 4a-c is more shielded (146.5 ppm), and the C-12 atom of double bond is more deshielded (108.5 ppm), respectively, in comparison with the chemical shifts of the corresponding carbons in acyclic compounds 2a-c.
In order to gain further insight about the cyclization of butenoate fragment the 1H-NMR spectra of the carbazole fragments were investigated in detail. The hydrogen resonances of this moiety in compounds 2a-c were completely and unambigously assigned by the concerted examination of their chemical shifts and spin-spin couplings. It is important to note that all hydrogen resonances of the fragment mentioned above were reliably distinguished by their characteristic splittting patterns. Spin-spin couplings over three (3JHCCH) bonds were derived for all hydrogens of the carbazole fragment with the exception of the H-4 atom. The narrow multiplicty induced by the detectable long-range – over four bond coupling (4JHCCCH) was observed for all hydrogens of the carbazole fragment with the exception of the H-1 atom. The formation of compounds 4a-c from 2a-c led to changes in the chemical shifts and multiplicities of some of the hydrogen atoms. For instance, the disappearance of the narrow splitting doublet resonating at 8 ppm and attributed to H-4 was detected, notwithstanding the fact that the doublet with three bond splitting attributed to H-2 was found to resonate in almost the same place. The chemical shifts of the resonances of H-6, H-7, H-8, which were remote from the changes in the molecule were less perturbed. The largest alternation in the chemical shift occurred for the H-5 atom.
A singlet corresponding to the CH group hydrogen of the side chain double bond is seen at 4.7 ppm for compounds 2a-c, though for compounds 4a-c it appears at 6.1 ppm after ring formation. The singlet of the CH3 group hydrogens of the acyclic chain is observed at 1.9 ppm, but the one in the ring is at 2.4 ppm. Finally, compounds 4a-b have no ester group, whose characteristic triplet and quadruplet were observed at 1.1 ppm and 4.1 ppm, respectively, in the spectra of compounds 2a-c. The proton of the NH group in cycle is also more deshielded. It resonates at 11.6 ppm, whereas the signal of the proton of the NH group of the acyclic chain in compounds 2a-c is at 10.4 ppm.
The data obtained from computer molecular modeling are in reasonable agreement with the NMR findings. The models of molecules of studied compounds were optimized to the total steric energy (Figure 1) by MM2 molecular mechanics and AM1 semi-empirical quantum mechanical methods. The computer molecular models demonstrated the turn of side chain towards the carbazole ring for compounds 2a-c, but the preference of the side chain for the straight structure in compound 3.
Molecules 11 00072 g001 550
Figure 1. View of optimized to the total steric energy molecular models of compounds 2b, 3 and 4b
Figure 1. View of optimized to the total steric energy molecular models of compounds 2b, 3 and 4b
Molecules 11 00072 g001
Extended Hückel partial charges derived from the optimized models of compounds 2a-c revealed more negative C-4 (-O.144 a. v) and H-4 (0.023 a.v.) atoms in comparison ones with C-2 (-0.122 a.v.) and H-4 (0.031 a. v.) of compounds 4a-c. This fact was one more argument for the cyclization onto the C-4 atom, with no participation of the carbazole ring C-2 atom. The close contact perceived between the CO group oxygen of the new heterocycle and the H-5 atom of the carbazole ring related to the deshielding of H-5 atom in compounds 4a-c.

Conclusions

It was determined that, depending on the reaction conditions, 9-alkyl-3-aminocarbazoles upon reaction with ethyl-3-oxobutanoate formed acylation or condensation products, whose intramolecular cyclization at 240-250 °C took place onto the 4-position of the carbazole ring providing substituted pyrido[2,3-c]carbazol-1-ones. Taking into consideration that carbazoles are structurally similar to benzenes, the synthesized compounds were successfully studied by NMR spectra using the substituent effect rules as for benzenes. The results obtained during the NMR investigation fully substantiated the structural distinctions of studied compounds. Computer molecular modeling data supported the findings deduced from the 13C-NMR and the 1H-NMR spectra.

Experimental

General

1H- and 13C-NMR spectra were recorded on a Bruker AC 250-P (250 MHz), Bruker DRX 500 (500 MHz) and Varian Unity Inova 300 MHz spectrometers operating in Fourier transform mode with TMS as an internal standard. The IR spectra were measured on a Perkin-Elmer Spectrum GX FT-IR system. Silica gel plates (Silufol UV-254) were used for analytical tlc. Mass spectral data were obtained on Waters (Micromass) ZQ 2000 Spectrometer. Physical properties, analytical data and yields of the prepared compounds are given in Table 2. The molecular modeling of the studied compounds was carried out using Chem 3D Ultra 9.0 [18].
Ethyl-3-[(9-methyl-9H-carbazol-3-yl)amino]but-2-enoate (2a). A mixture of 3-amino-9-methyl-carbazole (1a, 7.85 g, 0.04 mol), benzene (100 mL), ethyl-3-oxobutanoate (7.6 mL, 0.06 mol) and hydrochloric acid (0.5 mL) was refluxed for 5 h with azeotropic separation of the water formed. The benzene was evaporated under reduced pressure and the residue was poured into hexane (100 mL) and was kept cold for crystallization. The precipitate was filtered, washed with hexane and recrystallized from hexane.
Ethyl-3-[(9-ethyl-9H-carbazol-3-yl)amino]but-2-enoate (2b) was obtained from 3-amino-9-ethyl-carbazole 1b (15 g, 0.07 mol) in the same way as described for 2a. MS (m/z): 323.2 [M++1].
Ethyl-3-[(9-propyl-9H-carbazol-3-yl)amino]but-2-enoate (2c) was obtained from 3-amino-9-propylcarbazole 1c (15 g, 0.07 mol) in the same way as described for 2a.
N-(9-ethyl-9H-carbazol-3-yl)-3-oxobutanamide (3). The reaction mixture of 3-amino-9-ethylcarba-zole (1b, 2.1 g, 0.01 mol), ethyl-3-oxobutanoate (3.79 mL, 0.03 mol) and toluene (25 mL) was refluxed for 2 h and was kept in cold for crystallization. The precipitate formed was filtered off, washed with hexane and recrystallized from toluene.
3,7-Dimethyl-4,7-dihydro-1H-pyrido[2,3-c]carbazol-1-one (4a). A mixture of compound 2a (2 g, 0.006 mol) and mineral oil (15 mL) was heated at 240-250 °C for 20 min, then cooled down to 20 °C and diluted with hexane. The precipitate formed was filtered off, washed with hexane and recrystallized from dioxane.
7-Ethyl-3-methyl-4,7-dihydro-1H-pyrido[2,3-c]carbazol-1-one (4b) was obtained from compound 2b (1 g, 0.003 mol) in the same way as described for 4a. The product formed was purified by column chromatography (Silikagel L 40/100, eluent: acetone). MS (m/z): 277.2 [M++1].
3-Methyl-7-propyl-4,7-dihydro-1H-pyrido[2,3-c]carbazol-1-one (4c) was obtained from compound 2c (4 g, 0.01 mol) in the same way as described for 4a. The product formed was purified by column chromatography (Silikagel L 40/100, eluent: acetone).
Table
Table 1. Spectroscopic data of the prepared compounds (NMR: δ, ppm; J, Hz; IR: cm-1)
Table 1. Spectroscopic data of the prepared compounds (NMR: δ, ppm; J, Hz; IR: cm-1)
Compound1H-NMR (solvent)13C-NMR (solvent)IR (KBr tabl.)
2a(CD3)2CO): 1.24 (t, 3H, J3 = 7.1, COOCH2CH3), 1.97 (s, 3H, CCH3), 3.92 (s, 3H, NCH3), 4.11 (q, 2H, J = 7.1, COOCH2CH3), 4.67 (s, 1H, CH=), 7.21 (td, 1H, J3 = 6.8, J3 = 7.9, J4 = 1.3, Ar-6C-H), 7.30 (dd, 1H, J3 = 8.6, J4 = 2.0, Ar-2C-H), 7.48 (td, 1H, J3 = 6.8, J3 = 8.2, J4 = 1.3, Ar-7C-H), 7.53 (d, 1H, J3 = 8.6, Ar-1C-H), 7.54 (dd, IH, J3 = 8.2, J4 = 1.3, Ar-8CH), 7.98 (d, 1H, J4 = 2.0, Ar-4C-H), 8.17 (dd 1H, J3 = 7.9, J4 = 1.3, Ar-5C H), 10.48 (s, 1H, NH).(CD3)2CO): 14.96 (COOCH2CH3), 20.18 (CCH3), 29.48 (NCH3), 58.80 (COOCH2CH3), 85.09 (CH=), 109.80 (Ar-C-8), 109.89 (Ar-C-1), 118.01 (Ar-C-4), 119.71 (Ar-C-6), 121.22 (Ar-C-5), 123.17 (Ar-C-5a), 123.78 (Ar-C-4a), 124.77 (Ar-C-2), 126.92 (Ar-C-7), 131.73 (Ar-C-3), 139.91 (Ar-C-1a), 142.52 (Ar-C-8a), 161.26 (C=), 170.94 (CO).3250(NH), 1656(CO).
2b(d6-DMSO): 1.22 (t, 3H, J = 7.1, COOCH2CH3), 1.32 (t, 3H, J = 7.1, NCH2CH3), 1.96 (s, 3H, CCH3), 4.08 (q, 2H, J = 7.1, COOCH2CH3), 4.43 (q, 2H, J = 7.1, NCH2CH3), 4.68 (s, 1H, CH=), 7.19 (td, 1H, J3 = 7.4, J3 = 7.6, J4= 1.3, Ar-6C-H), 7.29 (dd, 1H, J3 = 8.6, J4 = 2.0, Ar-2C-H), 7.46 (td, 1H, J3 = 6.6, J3 = 7.4, J4 = 1.3, Ar-7C-H), 7.58 (d, 1H, J3 = 8.6, Ar-1CH), 7.59 (dd, 1H, J3 = 6.6, J3 = 1.3, Ar-8C-H), 8.02 (d, 1H, J4 = 2.0, Ar-4C-H), 8.18 (dd, 1H, J3 = 7.6, J4 =1.3, Ar-5C-H), 10.38 (s, 1H, NH).(d6-DMSO): 13.63 (NCH2CH3), 14.49 (COOCH2CH3), 19.76 (CCH3), 36.99 (NCH2CH3), 57.90 (COOCH2CH3), 83.93 (C=), 109.13 (Ar-C-8), 109.25 (Ar-C-1), 116.99 (Ar-C-4), 118.65 (Ar-C-6), 120.64 (Ar-C-5), 121.86 (Ar-C-5a), 122.42 (Ar-C-4a), 123.57 (Ar-C-2), 125.98 (Ar-C-7), 130.21 (Ar-C-3), 137.37 (Ar-C-1a), 140.03 (Ar-C-8a), 160.29 (C=), 169.48 (CO).3267(NH), 1652(CO).
2c(CDCl3): 0.98 (t, 3H, J=7.5, COOCH2CH3), 1.31 (t, 3H, J = 6.9, NCH2CH2CH3), 1.89 − 1.92 (m, 2H, NCH2CH2CH3), 1.94 (s, 3H, CCH3), 4.18 (q, 2H, J = 7.5, COOCH2CH3), 4.26 (q, 2H, J = 6.9, NCH2CH2CH3), 4.69 (s, 1H, CH=), 7.21 (dd, 1H, J3 = 8.2, J4 = 2.0, Ar-2C-H), 7.22 (td, 1H, J3 = 7.6, J3 = 8.2, J4 = 1.3, Ar-6C-H), 7.34 (dd, 1H, J3 = 6.9, J4 = 1.3, Ar-8C-H), 7.40 (d, 1H, J3 = 8.2, Ar-1C-H), 7.47 (td, 1H, J3 = 8.2, J3 = 6.9, J4 = 1.3, Ar-7C-H), 7.83 (d, 1H, J4 = 2.0, Ar-4C-H), 8.03 (dd, 1H, J3 = 7.6, J4 = 1.3, Ar-5C-H), 10.38 (s, 1H, NH).(CDCl3): 11.82 (NCH2CH2CH3), 14.68 (COOCH2CH3), 20.29 (CCH3), 22.34 (NCH2CH2CH3), 44.78 NCH2CH2CH3), 58.60 (COOCH2CH3), 84.22 (C=), 108.79 (Ar-C-8), 108.93 (Ar-C-1), 117.79 (Ar-C-4), 118.93 (Ar-C-6), 120.39 (Ar-C-5), 122.37 (Ar-C-5a), 122.99 (Ar-C-4a), 124.26 (Ar-C-2), 126.04 (Ar-C-7), 130.70 (Ar-C-3), 138.58 (Ar-C-1a), 141.05 (Ar-C-8a), 160.76 (C=), 170.61 (CO).3257(NH), 1651(CO).
3(CDCl3): 1.41 (t, 3H, J = 7.2, NCH2CH3), 2.36 (s, 3H, COCH3), 3.65 (s, 2H, COCH2), 4.32 (q, 2H, J = 7.2, NCH2CH3), 7.23 (td, 1H, J3 = 7.0, J3 = 7.8, J4 = 1.1, Ar-6C-H), 7.31 (d, 1H, J3 = 8.7, Ar-1C-H),7.40 (dd, 1H, J3 = 8.2, J4 = 1.1, Ar-8C-H), 7.49 (td, 1H, J3 = 8.2, J3 = 7.0, J4 = 1.1, Ar-7C-H), 7.55 (dd, 1H, J3 = 8.7, J4 = 2.0, Ar-2C-H), 8.08 (dd, 1H, J3 = 7.8, J4 = 1.1, Ar-5C-H), 8.36 (d, 1H, J4 = 2.0, Ar-4CH), 9.23 (s, 1H, NH).(CDCl3): 14.06 (NCH2CH3), 31.45 (COCH3), 37.81 (NCH2CH3), 50.30 (COCH2CO), 108.71 (Ar-C-8), 108.79 (Ar-C-1), 113.26 (Ar-C-4), 119.01 or 119.86 (Ar-C-6), 119.01 or 119.86 (Ar-C-2), 120.96 (Ar-C-5), 122.99 (Ar-C-5a), 123.21 (Ar-C-4a), 126.12 (Ar-C-7), 129.60 (Ar-C-3), 137.55 (Ar-C-1a), 140.66 (Ar-C-8a), 163.93 (NHCO), 205.54 (COCH3).3276(NH), 1721(CO), 1640(CO).
4a(d6-DMSO): 2.41 (s, 3H, CCH3), 3.97 (s, 3H, NCH3), 6.09 (CH=), 7.18 (td, 1H, J3 = 7.1, J3 = 8.2, Ar-6CH), 7.46 (td, 1H, J3 = 8.2, J3 = 7.1, Ar-7C-H), 7.60 (d, 1H, J3 = 8.2, Ar-8C-H), 7.69 (d, 1H, J3 = 8.9, Ar-1CH), 8.02 (d, 1H, J3 = 8.9, Ar-2C-H), 9.94 (d, 1H, J3 = 8.2, Ar-5C-H), 11.69 (s, 1H, NH).(d6-DMSO): 18.87 (CCH3), 29.01 (NCH3), 108.60 (CH=), 109.93 (Ar-C-1), 109.93 (Ar-C-8), 114.72 (Ar-C-2), 116.57 (Ar-C-4), 117.91 (Ar-C-6), 121.04 (Ar-C-4a), 121.04 (Ar-C-5a), 122.75 (Ar-C-5), 125.28 (Ar-C-7), 128.90 (Ar-C-3), 136.33 (Ar-C-1a), 140.70 (Ar-C-8a), 146.68 (C=), 177.97 (CO).3267(NH), 1623(CO).
4b(d6-DMSO): 1.28 (t, 3H, J = 7.2, NCH2CH3), 2.45 (s, 3H, CCH3), 4.52 (q, 2H, J = 7.2 NCH2CH3), 6.05 (s, 1H, CH=), 7.14 (t, 1H, J3 = 7.5, J3 = 8.2, Ar-6C-H), 7.42 (t, 1H, J3 = 7.5, J3 = 8.2, Ar-7C-H), 7.59 (d, 1H, J3 = 8.2, Ar-8C-H), 7.65 (d, 1H, J3 = 8,8, Ar-1C-H), 8.02 (d, 1H, J3 = 8.8, Ar-2C-H), 9.90 (d, 1H, J3 = 8.2, Ar-5C-H), 11.65 (s, 1H, NH).(d6-DMSO): 13.91 (NCH2CH3), 18.89 (CH3), 36.86 (NCH2CH3), 108.52 (CH=), 109.95 (Ar-C-1), 109.95 (Ar-C-8), 114.67 (Ar-C-2), 116.62 (Ar-C-4), 117.93 (Ar-C-6), 121.19 (Ar-C-4a), 121.19 (Ar-C-5a), 122.93 (Ar-C-5), 125.29 (Ar-C-7), 129.10 (Ar-C-3), 136.34 (Ar-C-1a), 139.58 (Ar-C-8a), 146.58 (C=), 177.97 (CO).3281(NH), 1619(CO).
4c(d6-DMSO): 0.85 (t, J = 7.2, 3H, NCH2CH2CH3), 1.75 − 1.82 (m, 2H, NCH2CH2CH3), 2.37 (s, 3H, CCH3), 4.55 (t, J = 7.2, 2H, NCH2CH2CH3), 6.04 (s, 1H, CH=), 7.13 (t, 1H, J3 = 7.6, J3 = 8.2, Ar-6C-H), 7.41 (t, 1H, J3 = 7.6, J3 = 8.2, Ar-7CH), 7.60 (d, 1H, J3 = 8.2, Ar-8C-H), 7.64 (d, 1H, J3 = 8.8, Ar-1C-H), 8.03 (d, 1H, J3 = 8.8, Ar-2CH), 9.90 (d, 1H, J3 = 8.2, Ar-5C-H), 11.63 (s, 1H, NH).(d6-DMSO): 11.31 (NCH2CH2CH3), 18.84 (CH3), 22.09 (NCH2CH2CH3), 43.53 (NCH2CH2CH3), 108.98 (CH=), 109.93 or 109.99 (Ar-C-1), 109.93 or 109.99 (Ar-C-8), 114.94 (Ar-C-2), 116.56 (Ar-C-4), 117.88 (Ar-C-6), 121.11 (Ar-C-5a), 121.11 (Ar-C-4a), 122.78 (Ar-C-5), 125.23 (Ar-C-7), 129.03 (Ar-C-3), 136.32 (Ar-C-1a), 140.13 (Ar-C-8a), 146.51 (C=), 177.98 (CO).3283(NH), 1643(CO).
Table
Table 2. The physical, analytical and yield data of the studied compounds
Table 2. The physical, analytical and yield data of the studied compounds
Compoundm. p. (°C)Molecular FormulaElemental analysis data (Calculated / Found) %Yield (%)
CHN
2a130 – 131C19H20N2O274.00 / 74.086.54 / 6.489.08 / 8.9680.0
2b134 – 135C20H22N2O274.51 / 74.466.88 / 7.098.69 / 8.4383.0
2c77 – 78C21H24N2O274.97 / 74.717.19 / 7.248.33 / 8.4376.0
3157 – 158C18H18N2O273.45 / 73.346.16 / 6.379.52 / 9.4573.0
4a> 330C17H14N2O77.84 / 77.635.38 / 5.1010.68 / 10.4563.0
4b254 – 256C18H16N2O78.24 / 78.205.84 / 5.8210.14 / 10.0946.0
4c274 – 275C19H18N2O79.90 / 79.864.59 / 4.629.81 / 9.9269.0

References

  1. Suffness, M.; Cordell, G.A. The Alkaloids; Brossi, A., Ed.; Academic Press: New York, 2000; Vol. 54, p. 395. [Google Scholar]
  2. Saxton, J.E. Indoles; Wiley-Interscience: New York, 1983; Pt. 4; p. 201. [Google Scholar]
  3. Kleemann, A.; Engel, J. Pharmazeutische Wirkstoffe; Georg Thieme Verlag: Stuttgart-New York, 1978; Volume V, p. 555. [Google Scholar]
  4. Kutkevicius, S.; Stanisauskaite, A.; Getautis, V.; Railaite, A. Synthesis of Carbazole Containing Organic Photosemiconductors Using Dimercapto Compounds. J. Prakt. Chem. 1995, 337, 315–318. [Google Scholar]
  5. Zhang, Y.; Wada, T.; Wang, L.; Sasabe, H. A Novel Approach to the Synthesis of Conjugated Carbazole Trimers as Multifunctional Cromophores for Photorefractive Materials. Tetrahedron Lett. 1997, 38, 1785–1788. [Google Scholar] [CrossRef]
  6. Elderfield, R.C. Heterocyclic Compounds; Wiley: New York, 1952; Vol. 4, p. 430. [Google Scholar]
  7. Reynolds, G.A.; Hauser, C.R. Org. Synth. 1949, 29, 70–71.
  8. Hesse, M.; Meier, H.; Zeeh, B. Spectroscopic Methods in Organic Chemistry; Georg Thieme Verlag: Stuttgart-New York, 1997; pp. 103-124, 142-163, 174. [Google Scholar]
  9. Kalinowski, H.O.; Berger, S.; Braun, S. 13C-NMR-Spektroskopie; Georg Thieme Verlag: Stuttgart-New York, 1984; pp. 84-122, 134-149, 283-308, 359. [Google Scholar]
  10. Sapijanskaite, B.; Mickevicius, V.; Mikulskiene, G. Synthesis of 1-(9-alkyl-9H-carbazol-3-yl)-4-carboxy-2-pyrrolidinone Derivatives. Khim. Geterotsikl. Soedin. 2003, 9, 1305–1315. [Google Scholar]
  11. Claramunt, R.M.; Lopez, C.; Sanz, D.; Alkorta, I.; Elguero, J.A. Multinuclear NMR Spectral Study of Parent Azoles and Benzazoles: Experimental Results and GIAO AB INITIO Calculations. Heterocycles 2001, 55, 2109–2121. [Google Scholar] [CrossRef]
  12. Oliveira, M.M.; Carvalho, L.M.; Moustrou, C.; Samat, A.; Guglielmetti, R.; Oliveira-Campos, A.M.F. NMR Analysis of a Series of Photochromic Pyranocarbazoles. Magn. Reson. Chem. 2001, 39, 637–640. [Google Scholar] [CrossRef]
  13. Balsells, R.E. 13C NMR Spectra of Substituted Carbazoles and Azacarbazoles (β-Carbolines). Magn. Reson. Chem. 1983, 26, 1109–1112. [Google Scholar] [CrossRef]
  14. Borovik, V.P.; Shakirov, M.M.; Shkurko, O.P. 1H and 13C-NMR Spectra of 9H-pyrimido[4,5-b]indoles. Khim. Geterotsikl. Soedin. 2003, 10, 1531–1537. [Google Scholar]
  15. Giraud, J.; Marzin, C. Comparative 13C NMR study of some Deuteriated and Undeuteriated Molecules. Org. Magn. Reson. 1979, 12, 649–651. [Google Scholar]
  16. Welti, D.H. Revision of the 13C NMR Signal Assignment of Harman, Based on One- and Two-Dimensional INADEQUATE Spectroscopy. Magn. Reson. Chem. 1985, 23, 872–876. [Google Scholar] [CrossRef]
  17. Shamma, M.; Hindenlang, D.M. Carbon –13 NMR Shift Assignments of Amines and Alkaloids; Plenum Press: New York-London, 1979; p. 97. [Google Scholar]
  18. Chem 3D Ultra 9.0, Cambridge Scientific Software; Serial number: 031 406391 4800.
  • Sample Availability: Available from the authors.

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MDPI and ACS Style

Sapijanskaite, B.; Mickevicius, Y.; Mikulskiene, G. Reactions of 9-Alkyl-3-aminocarbazoles with Ethyl-3-oxo-butanoate and Identification of the Products Obtained. Molecules 2006, 11, 72-80. https://doi.org/10.3390/11010072

AMA Style

Sapijanskaite B, Mickevicius Y, Mikulskiene G. Reactions of 9-Alkyl-3-aminocarbazoles with Ethyl-3-oxo-butanoate and Identification of the Products Obtained. Molecules. 2006; 11(1):72-80. https://doi.org/10.3390/11010072

Chicago/Turabian Style

Sapijanskaite, Birute, Ytautas Mickevicius, and Gema Mikulskiene. 2006. "Reactions of 9-Alkyl-3-aminocarbazoles with Ethyl-3-oxo-butanoate and Identification of the Products Obtained" Molecules 11, no. 1: 72-80. https://doi.org/10.3390/11010072

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