Bis(4-hydroxybenzyl)sulfide: a Sulfur Compound Inhibitor of Histone Deacetylase Isolated from Root Extract of Pleuropterus ciliinervis
Abstract
:Introduction
Results and Discussion
Compound | IC50 (μM) Enzyme | GI50 (μM) PC-3 |
---|---|---|
1 | 1.43 ± 0.03 | 7.65 ± 0.05 |
SAHA | 0.13 ± 0.01 | 0.74 ± 0.01 |
Cell line | Origin | Growth inhibition (μM) | |
---|---|---|---|
1 | SAHA | ||
ACHN | Kidney | 6.23 ± 0.07 | 0.67 ± 0.02 |
NCI-H23 | Lung | >10 | 1.32 ± 0.02 |
PC-3 | Prostate | 7.86 ± 0.06 | 0.75 ± 0.02 |
MDA-MB-231 | Breast | 1.45 ± 0.03 | 0.89 ± 0.02 |
LOX-IMVI | Melanoma | 6.14 ± 0.08 | 1.67 ± 0.02 |
HCT-15 | Colon | 7.89 ± 0.12 | 0.93 ± 0.06 |
Conclusions
Experimental
General
Plant material collection, extraction and purification
Cell Culture
MTT Assay
Histone deacetylase assay
Statistical analysis
Acknowledgments
References
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Son, I.H.; Lee, S.I.; Yang, H.D.; Moon, H.-I. Bis(4-hydroxybenzyl)sulfide: a Sulfur Compound Inhibitor of Histone Deacetylase Isolated from Root Extract of Pleuropterus ciliinervis. Molecules 2007, 12, 815-820. https://doi.org/10.3390/12040815
Son IH, Lee SI, Yang HD, Moon H-I. Bis(4-hydroxybenzyl)sulfide: a Sulfur Compound Inhibitor of Histone Deacetylase Isolated from Root Extract of Pleuropterus ciliinervis. Molecules. 2007; 12(4):815-820. https://doi.org/10.3390/12040815
Chicago/Turabian StyleSon, Il Hong, Sung Ik Lee, Hyun Duk Yang, and Hyung-In Moon. 2007. "Bis(4-hydroxybenzyl)sulfide: a Sulfur Compound Inhibitor of Histone Deacetylase Isolated from Root Extract of Pleuropterus ciliinervis" Molecules 12, no. 4: 815-820. https://doi.org/10.3390/12040815