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Molecules 2008, 13(11), 2717-2728; doi:10.3390/molecules13112717

Bioactive Pentacyclic Triterpenes from the Stems of Combretum laxum

Departamento de Química, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil, 79070-900
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Received: 22 September 2008 / Revised: 16 October 2008 / Accepted: 20 October 2008 / Published: 1 November 2008
(This article belongs to the Special Issue Triterpenes and Triterpenoids)
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Abstract

Two new triterpene glucosides, β-D-glucopyranosyl 2α,3β,24-trihydroxyolean- 12-en-28-oate and β-D-glucopyranosyl 2α,3β,23,24-tetrahydroxyurs-12-en-28-oate, in addition to nine known compounds belonging to three different triterpene classes (oleanane-, ursane- and lupane-type) have been isolated from the stems of a specimen of Combretum laxum growing in the “Pantanal” of the central-western region of Brazil. Among the known triterpenes, β-D-glucopyranosyl 2α,3β,6β-trihydroxyolean-12-en-28-oate is reported for the first time in the Combretaceae, while bellericoside and asiatic acid are described for the first time in the genus Combretum. The structures of the isolated compounds have been established on the basis of spectral techniques (1D-, 2D-NMR and MS). Their in vitro antifungal activities against standard strains of Candida albicans, C. krusei and Cryptococcus neoformans were also evaluated in this work.
Keywords: Combretum laxum; Combretaceae; triterpenes; antifungal activity Combretum laxum; Combretaceae; triterpenes; antifungal activity
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Bisoli, E.; Garcez, W.S.; Hamerski, L.; Tieppo, C.; Garcez, F.R. Bioactive Pentacyclic Triterpenes from the Stems of Combretum laxum. Molecules 2008, 13, 2717-2728.

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