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Molecules 2009, 14(11), 4440-4453; doi:10.3390/molecules14114440

The Effect of Long-Running Severe Selenium-Deficiency on the Amount of Iron and Zinc in the Organs of Rats

1
Department of Physical Chemistry, Showa Pharmaceutical University, 3-3165 Higashi- Tamagawagakuen, Machida-shi, Tokyo 194-8543, Japan
2
Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, Japan
*
Author to whom correspondence should be addressed.
Received: 5 October 2009 / Revised: 2 November 2009 / Accepted: 4 November 2009 / Published: 5 November 2009
(This article belongs to the Special Issue Selenium and Tellurium Chemistry)
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Abstract

The amounts of selenium (Se), iron (Fe), and zinc (Zn) in the liver, kidney, and spleen as a function of age of rats measured using instrumental neutron activation analysis were compared between Se-deficient (SeD) rats and normal rats. The SeD model rats can live for more than 50 weeks. The effect of Se-deficinecy in rats might be weak, compared to the marked malfunction of GSH-Px. The SeD rats can be considered as a model of nonlethal chronic oxidative stress. Fluctuations of Fe and Zn in the liver of Se-deficient rats were observed. The amount of redox-relating minerals, such as Fe and Zn, in SeD rat organs is changeable depending on the age.
Keywords: instrumental neutron activation analysis; bio-trace element; mineral; aging; oxidative stress instrumental neutron activation analysis; bio-trace element; mineral; aging; oxidative stress
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Matsumoto, K.-I.; Terada, S.; Ariyoshi, M.; Okajo, A.; Hisamatsu, A.; Ui, I.; Endo, K. The Effect of Long-Running Severe Selenium-Deficiency on the Amount of Iron and Zinc in the Organs of Rats. Molecules 2009, 14, 4440-4453.

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