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Article

Silica Sulfuric Acid Promotes Aza-Michael Addition Reactions under Solvent-Free Condition as a Heterogeneous and Reusable Catalyst

by
Yan Wang
,
Yan-Qin Yuan
and
Sheng-Rong Guo
*
Department of Chemistry and Biology, Lishui University, Lishui, Zhejiang 323000, China
*
Author to whom correspondence should be addressed.
Molecules 2009, 14(11), 4779-4789; https://doi.org/10.3390/molecules14114779
Submission received: 3 November 2009 / Revised: 19 November 2009 / Accepted: 23 November 2009 / Published: 23 November 2009
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Abstract

:
A highly efficient, inexpensive, recyclable, convenient, and green protocol for chemoselective aza-Michael addition reactions of amines/thiols to α,β-unsaturated compounds using silica sulfuric acid (SSA or SiO2-SO3H) was developed. This method is simple, convenient and the title compounds are produced in good to excellent yields.

Introduction

The Michael reaction has been studied for over a century. The conjugate addition of amines to carbon–carbon double bonds is a useful protocol in synthetic organic chemistry [1,2,3,4]. It is used extensively in the synthesis of pharmaceutical intermediates, peptide analogues, antibiotics, and other biologically active molecules and drugs [5,6,7,8,9,10]. In the past few years, a number of alternative procedures have been developed for the conjugate addition of amines to α,β-unsaturated carbonyl compounds. In particular, various Lewis acid catalyzed reactions have been reported. This reaction has been investigated using catalysts such as lanthanum trichloride (LaCl3) [11], bromodimethylsulfonium bromide [12], silica supported perchloric acid [13], cerium(IV) ammonium nitrate (CAN) [14,15], β-cyclodextrin [16], zirconium(IV) chloride [17], samarium(III) triflate [18], ZrOCl2·8H2O on montmorillonite K10 [19], N-methylimidazole [20], Cu(acac)2 /ionic liquid [21], 1,8-diazabicyclo[5.4.0] undec-7-ene (DBU) [22], bismuth (III)triflate [23], cadmium chloride (CdCl2) [24], Y(NO3)3·6H2O [25], and cellulose supported copper(0) [26]. Unfortunately, many of these processes suffer from limitations, such as the use of expensive reagents, harsh conditions, relatively long reaction times, high catalyst loading, low selectivity and tedious work-up procedures for their separation, recycling, or disposal problems and effluent pollution. All these limitations prompted us to explore other better catalysts, which have more efficiency and less limitations. We tried to find a catalyst that has certain properties, such as the good thermal and mechanical stabilities of supported reagents, is easy to handle, of low toxicity, non-corrosive, easy to separate from reaction mixtures through filtration, and feasible for reuse.
Very recently, silica sulfuric acid (SSA) has been widely used as a reusable, heterogeneous, inexpensive solid Brønsted acid catalyst and has received much attention [27,28,29,30] and there has been increasingly awareness about the use of solid acids such as silica sulfuric acid (SSA) for synthesizing organic intermediates and fine chemicals [31,32,33,34]. SSA is a strong Brønsted and Lewis acid, presumably arising from the formation of SiO2-SO3H sites on the surface. This heterogeneous catalyst can be easily separated from the reaction media, has greater selectivity, and is recyclable, easier to handle, more stable, nontoxic, and insoluble in organic solvents. We hoped that SSA would be a superior proton source to the standard acidic solid supports for running Michael reactions under heterogeneous conditions, and herein we wish to report the use of SSA as a reusable solid acid catalyst for the Michael addition reaction.

Results and Discussion

In a set of initial experiments, acrylic acid 2-phenylsulfanyl-ethyl ester(PTEA)was allowed to react with morpholine in the presence of a varying quantities of SiO2-SO3H. The results show that an excellent yield of the Michael adduct can be achieved by reacting a mixture of morpholine (1.2 equiv.) and PTEA (1.0 equiv) in the presence of SiO2-SO3H (SSA, 100 mg) at room temperature (Scheme 1). This encouraged us to exploit the generality and scope of this reaction catalyzed by SiO2-SO3H by using other Michael acceptors with various aromatic and aliphatic amines. As shown in Table 1, the Michael addition of various aliphatic amines and aryl amines carrying either electron-donating or electron-withdrawing groups were successfully reacted with PTEA or PEEA to produce their corresponding Michael adducts in high to excellent yields. The addition of primary amines such as benzylamine resulted in only monoalkylated products; the aromatic amines showed poor reactivity compared to the aliphatic amines. No side products were observed when using excess amines; pure products could be obtained by removal of the catalyst by filtration followed by column chromatography. The Michael addition of heteroaromatic imidazole with PTEA took more time (analysis by TLC and GC) as compared with other amines and gave a low yield of product which may be due to the weak nucleophilicity of the imidazole molecule steming from its aromaticity. The reactions with 4-nitroaniline and 2-aminophenol did not proceed at all, even at higher temperatures (entries 13, 14).
An experiment was performed to show the chemoselectivity between thiols and aniline by using 2-aminobenzenethiol (1.2 mmol) and PTEA (1.0 mmol) in the presence of SSA (0.1 g) at room temperature. After 30 min, compound 11 was the only product (Scheme 2).
Another competition reaction was also carried out by using 3-ethyl-4- hydroxythiophenol (1.2 mmol), and PTEA (1 mmol) in the presence of SSA (0.1 g) at room temperature, and compound 12 was formed as the only product (Scheme 3). From the above two experiments, we conclude that the activity of the amines and phenols are both less than that of thiols.
We also examined the reaction of aniline with PTEA using different protic and aprotic solvents in the presence of SiO2-SO3H at different temperature. The results showed that solvent-free conditions gave a better yield of β-amino compound (Table 2).
The catalyst system was found to be recyclable and the reaction condition can be scaled up. In order to test the reusability of the catalyst, a reaction of PTEA (10 mmol) and morpholine (12 mmol) was carried out in the presence of SSA (1.0 g) and the catalyst was recovered after completion and activated by heating at 100 °C under vacuum for 1 h. The recovered catalyst was reused for the aza-Michael reaction of another batch of PTEA (10 mmol) and morpholine (12 mmol) giving 90% yield of the desired product after 1 h. Again, the catalyst was recovered, reactivated and reused repeatedly for three more consecutive times for aza-Michael reactions affording 85%, 70% and 70% yields, respectively. From this observation, it is clear that the reaction can be scaled up and the catalyst is reusable with a slight decrease in catalytic activity.
To compare the catalytic activity of SiO2-SO3H with ordinary silica, an identical experiment was performed by stirring an intimate mixture of PTEA (1.0 mmol), morpholine (1.2 mmol) and silica (240-400 mesh, 100 mg) at room temperature. No aza-Michael addition product was formed even after 24 h, which indicate that the requirement of SiO2-SO3H is key factor for the successful outcome of the reaction. Furthermore, using of SiO2-SO3H in the aza-Michael addition reduces the cost of the catalysts, and the reaction completed in less time. It is not very clear whether SiO2-SO3H act as a solid acid catalyst or as a reservoir providing a small concentration of acid in solution. However, from the experiments carried out using recovered SiO2-SO3H suggest that it acts as a solid acid in the aza-Michael reactions.

Experimental

General

All reagents were purchased from commercial sources and used without further purification. TLC analysis was performed with glass backed plates precoated with silica gel and examined under UV (254 nm). NMR spectra were measured in CDCl3 with Me4Si as the internal standard on a Bruker Advance 300 instrument at room temperature. IR spectra were recorded on Bruker FT-IR spectrometer, absorbances are reported in cm-1. Elemental analyses were performed on a Perkin–Elmer-2400 elemental analyzer.

General procedure for the synthesis of β-amino carbonyl compounds

A mixture of aniline (1.2 mmol) and Michael acceptor PTEA (1.0 mmol or PEEA 1.0 mmol) and SSA (0.1 g) was stirred at room temperature for 0.5–6 h. The reaction was monitored by TLC. Upon completion, EtOAc (5 mL) was added and the SiO2-SO3H catalyst can be reused after it was removed by filtration. The filtrate was washed with saturated NaHCO3 (aq) and brine, then dried with anhydrous Na2SO4, and concentrated under vacuum. The residue was analyzed by NMR. In most cases, pure product was obtained. If needed, the residue was further purified by silica gel column chromatography using a 4:1 hexane–EtOAc mixture as eluent to afford the pure product. All of the products are new compounds, and the structures of products were determined from their NMR, MS or elemental analyses.

Selected spectroscopic data

3-Phenylaminopropionic acid 2-phenylsulfanyl-ethyl ester (1): yellow oil; 1H-NMR δ: 7.42 (d, J = 7.7 Hz, 2H), 7.18-7.34 (m, 5H), 6.75 (t, J = 7.3 Hz, 1H), 6.62 (d, J = 8.0 Hz, 2H), 4.30 (t, J = 6.8 Hz, 2H), 3.95 (br 1H), 3.46 (t, J = 6.3 Hz, 2H), 3.17 (t, J = 6.8 Hz, 2H), 2.62 (t, J = 6.3 Hz, 2H); 13C-NMR δ: 172.1, 147.5, 134.9, 130.1, 129.3, 129.1, 126.7, 117.8, 113.1, 63.0, 39.4, 33.9, 32.5; Anal. Calcd. for C17H19NO2S: C, 67.74; H, 6.35. Found: C, 67.76; H, 6.34.
3-p-Tolylaminopropionic acid 2-phenylsulfanyl-ethyl ester (2): yellow oil; 1H-NMR δ: 7.43-7.21 (m, 5H), 7.02 (d, J = 8.2 Hz, 2H), 6.58 (d, J = 8.2Hz, 2H), 4.29 (t, J = 6.8 Hz, 2H), 3.93 (br, 1H), 3.44 (t, J = 6.3 Hz, 2H), 3.16 (t, J = 6.8 Hz, 2H), 2.60 (t, J = 6.2 Hz, 2H), 2.27(s, 3H); 13C-NMR δ: 172.2, 145.2, 134.9, 130.1, 129.8, 129.1, 127.0, 126.7, 113.3, 62.9, 39.8, 33.8, 32.5, 20.4; Anal. Calcd. for C18H21NO2S: C, 68.54; H, 6.71. Found: C, 68.56; H, 6.68.
3-(4-Methoxyphenylamino)-propionic acid 2-phenylsulfanyl-ethyl ester (3): Off-white oil; 1H-NMR δ: 7.23-7.42 (m, 5H), 6.80 (q, J = 2.3 Hz, J = 6.9 Hz, 2H), 6.62 (d, J = 2.3 Hz, J = 6.9 Hz, 2H), 4.29 (t, J = 6.8 Hz, 2H), 3.76 (s, 3H), 3.43 (br, 1H), 3.40 (t, J = 6.3 Hz, 2H), 3.16 (t, J = 6.8 Hz, 2H), 2.58 (t, J = 6.3 Hz, 2H); 13C-NMR δ: 172.2, 152.5, 141.7, 135.0, 129.8, 129.0, 126.7, 114.9, 114.6, 63.9, 55.8, 40.5, 33.9, 32.5; Anal. Calcd. for C18H21NO3S: C, 65.23; H, 6.39. Found: C, 65.15; H, 6.34.
3-(4-Chlorophenylamino)propionic acid 2-phenylsulfanyl-ethyl ester (4): Off-white oil; 1H-NMR δ: 7.41 (d, J = 1.5 Hz, 2H), 7.23-7.39 (m, J = 6.4 Hz, 3H), 7.13 (t, J = 2.2 Hz, 2H), 6.59 (t, J = 2.0 Hz, 2H), 4.29 (t, J = 6.8 Hz, 2H), 3.97 (br, 1H), 3.42 (t, J = 6.2 Hz, 2H), 3.16 (t, J = 6.8 Hz, 2H), 2.58 (t, J = 6.2, 2H); 13C-NMR δ: 171.0, 143.9, 136.4, 129.6, 129.3, 128.9, 126.1, 125.1, 114.9, 63.6, 39.0, 37.8, 35.7; Anal. Calcd. for C17H18ClNO2S: C, 60.80; H, 5.40. Found: C, 60.83; H, 5.42.
3-(3,4-Dichlorophenylamino)propionic acid 2-phenylsulfanyl-ethyl ester (5): yellow oil; 1H-NMR δ: 7.56-7.78 (m, 3H), 7.14-7.21 (m, 3H), 6.71 (d, J = 8.2 Hz, 2H), 5.59 (br, 1H), 4.27 (t, J = 6.8 Hz, 2H), 3.36 (t, J = 6.3 Hz, 2H), 3.12 (t, J = 6.8 Hz, 2H), 2.60 (t, J = 6.3 Hz, 2H); 13C-NMR δ: 172.3, 155.8, 136.1, 134.5, 132.9, 131.4, 131.1, 130.6, 127.6, 124.2, 116.4, 63.2, 34.5 , 31.4, 22.5; Anal. Calcd. for C17H17Cl2NO2S: C, 55.14; H, 4.63. Found: C, 55.10; H, 4.65.
3-Morpholin-4-ylpropionic acid 2-phenylsulfanyl-ethyl ester (6): Off-white oil; 1H-NMR δ: 7.42-7.38 (m, 2H), 7.28-7.34 (m, 2H), 7.25-7.22 (m, 1H), 4.27 (t, J = 6.8 Hz, 2H), 3.73-3.71 (m, 4H), 3.15 (t, J = 6.8 Hz, 2H), 2.71 (t, J = 7.2 Hz, 2H), 2.38-2.46 (m, 6H); 13C-NMR δ: 171.9, 135.1, 129.9, 129.1, 126.6, 66.5, 63.0, 53.6, 53.1, 32.4, 31.4; Anal. Calcd. for C15H21NO3S: C, 60.99; H, 7.17. Found: C, 60.97; H, 7.16.
3-Diethylamino-propionic acid 2-phenylsulfanyl-ethyl ester (7): Off-white oil; 1H-NMR δ: 7.13-7.28 (m, 5H), 4.46 (t, J = 6.8 Hz, 2H), 3.74 (t, J = 6.3 Hz, 2H), 3.12 (t, J = 6.8 Hz, 2H), 2.78 (t, J = 6.3 Hz, 2H), 2.43 (q, J = 6.2 Hz, 4H), 1.10 (t, J = 6.2 Hz, 6H); 13C-NMR δ: 172.1, 135.6, 128.7, 126.6, 124.9, 66.5, 48.6, 46.8, 53.1, 34.8, 16.7; Anal. Calcd. for C15H23NO2S: C, 64.02; H, 8.24. Found: C, 64.04; H, 8.25.
3-Piperidin-1-yl-propionic acid 2-phenylsulfanyl-ethyl ester (8): Off-white oil; 1H-NMR δ: 7.75-7.85 (m, 3H), 7.43-7.51 (m, 2H), 4.33 (t, J = 6.8 Hz, 2H), 3.68 (t, J = 7.2 Hz, 2H), 2.63 (t, J = 6.8 Hz, 2H), 2.44 (t, J = 7.2 Hz, 2H), 2.34 (br, 10H); 13C-NMR δ: 171.9, 135.1, 129.9, 129.1, 126.6, 66.5, 63.0, 53.6, 53.1, 32.4, 31.4, 29.8; Anal. Calcd. for C16H23NO2S: C, 65.49; H, 7.90. Found: C, 65.51; H, 7.91.
3-Benzylaminopropionic acid 2-phenylsulfanyl-ethyl ester (9): Off-white oil; 1H-NMR δ: 7.21-7.38 (m, 10H), 4.27 (t, J = 6.8 Hz, 2H), 3.81(s, 2H), 3.16 (t, J = 6.3 Hz, 2H), 2.90 (t, J = 6.8 Hz, 2H), 2.52 (t, J = 6.3 Hz, 2H); 13C-NMR δ: 172.5, 140.1, 135.1, 130.0, 129.1, 128.5, 128.0, 127.0, 126.6, 62.8, 53.8, 44.4, 34.7, 32.4; Anal. Calcd. for C18H21NO2S: C, 68.54; H, 6.71. Found: C, 68.53; H, 6.68.
3-Imidazol-1-yl-propionic acid 2-phenylsulfanyl-ethyl ester (10): Off-white oil; 1H-NMR δ: 7.56 (s, 1H), 6.97-7.09 (m, 5H), 6.87 (d, J = 7.3 Hz, 2H), 4.36 (t, J = 6.8 Hz, 2H), 3.96 (t, J = 6.3 Hz, 2H), 3.16 (t, J = 6.8 Hz, 2H), 2.60 (t, J = 6.3 Hz, 2H); 13C-NMR δ: 170.2, 141.3, 129.9, 127.9., 126.7, 125.2, 124.8, 122.9, 65.6, 39.5, 32.4, 31.6; Anal. Calcd. for C14H16N2O2S: C, 60.85; H, 5.84. Found: C, 60.87; H, 5.82.
3-(2-Aminophenylsulfanyl)propionic acid 2-phenylsulfanyl-ethyl ester (11): Off-white Oil; 1H-NMR δ: 7.15-7.42 (m, J = 7.3 Hz, 7H), 6.67-6.75 (m, 2H), 4.40 (br, 2H), 4.25 (t, J = 6.8 Hz, 2H), 3.15 (t, J = 6.3 Hz, 2H), 2.96 (t, J = 6.8 Hz, 2H), 2.54 (t, J = 6.3 Hz, 2H); 13C-NMR δ: 171.7, 148.7, 136.6, 135.0, 130.2, 130.0, 129.1, 126.7, 118.5, 116.4, 115.0, 63.2, 34.5, 32.4, 29.5; Anal. Calcd. for C17H19NO2S2: C, 61.23; H, 5.74. Found: C, 61.25; H, 5.72.
3-(3-Ethyl-4-hydroxyphenylsulfanyl)propionic acid 2-phenylsulfanyl-ethyl ester (12): yellow oil; 1H- NMR δ: 7.15-7.43 (m, 6H), 6.69-6.72 (m, J = 8.2 Hz, 2H), 5.56 (br, 1H), 4.27 (t, J = 6.8 Hz, 2H), 3.15 (t, J = 6.3 Hz, 2H), 3.02 (t, J = 6.8 Hz, 2H), 2.54-2.66 (m, 4H), 1.24 (t, J = 7.6 Hz, 3H); 13C-NMR δ: 172.1, 153.6, 135.0, 134.1, 131.7, 131.2, 130.0, 129.1, 126.7, 124.7, 115.9, 63.2, 34.5, 32.4, 31.1, 22.9, 13.9; Anal. Calcd. for C19H22O3S2: C, 62.95; H, 6.12. Found: C, 62.92; H, 6.14.
3-Phenylaminopropionic acid 2-(naphthalen-2-ylsulfanyl)-ethyl ester (13): yellow oil; 1H-NMR δ: 7.73-7.81 (m, 4H), 7.42-7.52 (m, 4H), 7.04 (d, J = 8.1 Hz, 2H), 6.45 (d, J = 8.1 Hz, 2H), 4.29 (t, J = 6.7 Hz, 2H), 3.91 ( br, 1H), 3.41 (t, J = 6.3 Hz, 2H), 3.24 (t, J = 6.7 Hz, 2H), 2.57 (t, J = 6.3 Hz, 2H); 13C-NMR δ: 172.0, 145.6, 132.9, 132.6, 131.7, 129.9, 128.2, 128.2, 127.9, 127.5, 127.2, 126.4, 126.2, 116.7, 112.8, 63.4, 39.5, 33.3, 32.1; Anal. Calcd. for C21H21NO2S: C, 71.76; H, 6.02. Found: C, 71.79; H, 6.00.
3-p-Tolylaminopropionic acid 2-(naphthalen-2-ylsulfanyl)-ethyl ester (14): white solid, m.p. 75-77 °C; 1H-NMR δ: 7.76-7.83 (m, 4H), 7.49 (t, J = 8.4 Hz, 3H), 7.01 (d, J = 8.1 Hz, 2H), 6.56 (d, J = 8.1 Hz, 2H), 4.32 (q, J = 6.7 Hz, 2H), 3.90 ( br, 1H), 3.41 (t, J = 6.3 Hz, 2H), 3.25 (m, J = 6.7 Hz, 2H), 2.57 (t, J = 6.3 Hz, 2H), 2.51 (s, 3H); 13C-NMR δ: 172.2, 145.2, 133.7, 132.4, 132.0, 129.8, 128.7, 128.2, 128.1, 127.7, 127.2, 127.0, 126.7, 126.0, 113.4, 62.9, 39.8, 33.9, 32.4, 20.4; Anal. Calcd. for C22H23NO2S: C, 72.30; H, 6.34. Found: C, 72.32; H, 6.36.
3-(4-Methoxyphenylamino)propionic acid 2-(naphthalen-2-ylsulfanyl)-ethyl ester (15): Off-white oil; 1H-NMR δ: 7.78-7.89 (m, 4H), 7.46-7.54 (m, 3H), 6.82 (d, J = 8.8 Hz, 2H), 6.63 (d, J = 8.8 Hz, 2H), 4.35 (t, J = 6.8 Hz, 2H), 3.82 (br, 1H), 3.75 (s, 3H), 3.38 (t, J = 6.3 Hz, 2H), 3.27 (t, J = 6.3 Hz, 2H), 2.58 (t, J = 6.8 Hz, 2H); 13C-NMR δ: 172.2, 152.6, 141.7, 133.8, 132.5, 132.0, 128.7, 128.0, 127.9, 127.7, 127.2, 126.7, 126.0, 115.1, 114.8, 63.1, 55.8, 40.6, 33.9, 32.3; Anal. Calcd. for C22H23NO3S: C, 69.26; H, 6.08. Found: C, 69.29; H, 6.05.
3-Morpholin-4-yl-propionic acid 2-(naphthalen-2-ylsulfanyl)-ethyl ester (16): yellow oil; 1H-NMR δ: 7.73-7.83 (m, 4H), 7.40-7.49 (m, 3H), 4.31 (t, J = 6.8 Hz, 2H), 3.67 (t, J = 4.6 Hz, 4H), 3.23 (t, J = 6.8 Hz, 2H), 2.64 (t, J = 7.3 Hz, 2H), 2.41-2.46 (tt, J = 7.3 Hz, J = 4.6 Hz, 6H); 13C-NMR δ: 171.0, 135.1, 133.9, 128.3, 127.2, 126.5, 126.3, 126.1, 124.7, 66.5, 63.0, 53.6, 53.1, 32.4, 31.4; Anal. Calcd. for C19H23NO3S: C, 66.06; H, 6.71. Found: C, 66.08; H, 6.73.

Conclusions

In conclusion, we have described herein the scope and limitations of the use of silica sulfuric acid (SSA or SiO2-SO3H) as a highly efficient catalyst for Michael additions of amines under solvent-free conditions. This process avoids the use of organic solvent to carry out the reaction, and the catalyst can be separated from the product very easily after the reaction. Handling of the catalyst is easy, and it can be used again.

Acknowledgements

This work was funded by the Natural Science Foundation of Zhejiang Province, P.R. China (Project Y407240) and key project of Lishui University.

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Sample Availability: Contact the authors.
Molecules 14 04779 sch001 550
Scheme 1. Michael addition of aliphatic and aromatic amines with PTEA or PEEA.
Scheme 1. Michael addition of aliphatic and aromatic amines with PTEA or PEEA.
Molecules 14 04779 sch001
Molecules 14 04779 sch002 550
Scheme 2. Michael addition of 2-aminobenzenethiol to PTEA.
Scheme 2. Michael addition of 2-aminobenzenethiol to PTEA.
Molecules 14 04779 sch002
Molecules 14 04779 sch003 550
Scheme 3. Michael addition of 3-ethyl-4-hydroxythiophenol to PTEA.
Scheme 3. Michael addition of 3-ethyl-4-hydroxythiophenol to PTEA.
Molecules 14 04779 sch003
Table
Table 1. Michael addition of amines catalyzed by SSA under solvent-free conditions.
Table 1. Michael addition of amines catalyzed by SSA under solvent-free conditions.
EntryAmineMichael acceptorProductTime
(h)		Yield
(%) b
1 Molecules 14 04779 i001PTEA Molecules 14 04779 i0020.592
2 Molecules 14 04779 i003PTEA Molecules 14 04779 i0041.588
3 Molecules 14 04779 i005PTEA Molecules 14 04779 i0060.590
4 Molecules 14 04779 i007PTEA Molecules 14 04779 i0081.096
5 Molecules 14 04779 i009PTEA Molecules 14 04779 i0101.585
6 Molecules 14 04779 i011PTEA Molecules 14 04779 i0120.595
7 Molecules 14 04779 i013PTEA Molecules 14 04779 i0141.593
8 Molecules 14 04779 i015PTEA Molecules 14 04779 i0161.588
9 Molecules 14 04779 i017PTEA Molecules 14 04779 i0182.086
10 Molecules 14 04779 i019PTEA Molecules 14 04779 i0204.012
11 Molecules 14 04779 i021PTEA Molecules 14 04779 i0220.594
12 Molecules 14 04779 i023PTEA Molecules 14 04779 i0240.591
13 Molecules 14 04779 i025PTEANo Reaction
14 Molecules 14 04779 i026PTEANo Reaction
15 Molecules 14 04779 i027PEEA Molecules 14 04779 i0282.586
16 Molecules 14 04779 i029PEEA Molecules 14 04779 i0303.090
17 Molecules 14 04779 i031PEEA Molecules 14 04779 i0321.089
18 Molecules 14 04779 i033PEEA Molecules 14 04779 i0340.592
Table
Table 2. Michael addition reaction of PTEA with aniline in protic and aprotic solvents.
Table 2. Michael addition reaction of PTEA with aniline in protic and aprotic solvents.
EntrySolventYield (%)
1
2
3
4
5
6
7
8		C2H5OH
H2O
CH3CO2H
ClCH2CH2Cl
Toluene
CH3CN
CH2Cl 2
Neat		72
34
78
83
41
86
86
91

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MDPI and ACS Style

Wang, Y.; Yuan, Y.-Q.; Guo, S.-R. Silica Sulfuric Acid Promotes Aza-Michael Addition Reactions under Solvent-Free Condition as a Heterogeneous and Reusable Catalyst. Molecules 2009, 14, 4779-4789. https://doi.org/10.3390/molecules14114779

AMA Style

Wang Y, Yuan Y-Q, Guo S-R. Silica Sulfuric Acid Promotes Aza-Michael Addition Reactions under Solvent-Free Condition as a Heterogeneous and Reusable Catalyst. Molecules. 2009; 14(11):4779-4789. https://doi.org/10.3390/molecules14114779

Chicago/Turabian Style

Wang, Yan, Yan-Qin Yuan, and Sheng-Rong Guo. 2009. "Silica Sulfuric Acid Promotes Aza-Michael Addition Reactions under Solvent-Free Condition as a Heterogeneous and Reusable Catalyst" Molecules 14, no. 11: 4779-4789. https://doi.org/10.3390/molecules14114779

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