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Molecules 2011, 16(9), 7621-7626; doi:10.3390/molecules16097621

Synthesis of No-Carrier-Added 4-[18F]Fluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide

Institute of Neuroscience and Medicine, INM-5: Nuclear Chemistry, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany
Current address: Institute of Nuclear Chemistry, Johannes Gutenberg-University Mainz, 55128 Mainz, Germany.
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Author to whom correspondence should be addressed.
Received: 11 August 2011 / Revised: 24 August 2011 / Accepted: 31 August 2011 / Published: 6 September 2011
(This article belongs to the Special Issue Fluorine Chemistry 2016)
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Abstract

4-[18F]Fluorophenol is a versatile synthon for the synthesis of more complex radiopharmaceuticals bearing a 4-[18F]fluorophenoxy moiety. In order to prepare 4-[18F]fluorophenol in no-carrier-added (n.c.a.) form only a nucleophilic labelling method starting from [18F]fluoride is suitable. In this paper a new, two step radiosynthesis starting from 4-benzyloxyphenyl-(2-thienyl)iodonium bromide and [18F]fluoride with subsequent deprotection is described, yielding n.c.a. [18F]fluorophenol in 34 to 36% radiochemical yield.
Keywords: fluorine-18; 4-[18F]fluorophenol; diaryl iodonium salts; radiosynthesis; positron emission tomography fluorine-18; 4-[18F]fluorophenol; diaryl iodonium salts; radiosynthesis; positron emission tomography
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Ross, T.L.; Ermert, J.; Coenen, H.H. Synthesis of No-Carrier-Added 4-[18F]Fluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide. Molecules 2011, 16, 7621-7626.

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