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Molecules 2012, 17(10), 11303-11314; doi:10.3390/molecules171011303
Article

Benzopyranones from the Endophytic Fungus Hyalodendriella sp. Ponipodef12 and Their Bioactivities

1, 1, 1, 1, 1, 1, 1,*  and 2,*
1 College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China 2 College of Science, China Agricultural University, Beijing 100193, China
* Authors to whom correspondence should be addressed.
Received: 16 August 2012 / Revised: 4 September 2012 / Accepted: 19 September 2012 / Published: 25 September 2012
(This article belongs to the Section Natural Products)
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Abstract

The endophytic fungus Hyalodendriella sp. Ponipodef12 was isolated from the hybrid ‘Neva’ of Populus deltoides Marsh × P. nigra L. In this study, four benzopyranones were isolated from the ethyl acetate extract of Hyalodendriella sp. Ponipodef12, and identified as palmariol B (1), 4-hydroxymellein (2), alternariol 9-methyl ether (3), and botrallin (4) by means of physicochemical and spectroscopic analysis. All the compounds were evaluated for their antibacterial, antifungal, antinematodal and acetylcholinesterase inhibitory activities. 4-Hydroxymellein (2) exhibited stronger antibacterial activity than the other compounds. Palmariol B (1) showed stronger antimicrobial, antinematodal and acetylcholinesterase inhibitory activities than alternariol 9-methyl ether (3) which indicated that the chlorine substitution at position 2 may contribute to its bioactivity. The results indicate the potential of this endophytic fungus as a source of bioactive benzopyranones.
Keywords: poplar hybrid ‘Neva’ endophytic fungus; Hyalodendriella sp. Ponipodef12; benzopyranones; palmariol B; 4-hydroxymellein; alternariol 9-methyl ether; botrallin; bioactivities poplar hybrid ‘Neva’ endophytic fungus; Hyalodendriella sp. Ponipodef12; benzopyranones; palmariol B; 4-hydroxymellein; alternariol 9-methyl ether; botrallin; bioactivities
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Meng, X.; Mao, Z.; Lou, J.; Xu, L.; Zhong, L.; Peng, Y.; Zhou, L.; Wang, M. Benzopyranones from the Endophytic Fungus Hyalodendriella sp. Ponipodef12 and Their Bioactivities. Molecules 2012, 17, 11303-11314.

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