Next Article in Journal
Silica Gel-Mediated Organic Reactions under Organic Solvent-Free Conditions
Previous Article in Journal
Chemical Characterization of Volatile Compounds of Lantana camara L. and L. radula Sw. and Their Antifungal Activity
Article Menu

Export Article

Open AccessArticle
Molecules 2012, 17(10), 11456-11468; doi:10.3390/molecules171011456

Synthesis and Anticancer Activity of Di(3-thienyl)methanol and Di(3-thienyl)methane

1
Plasma Bioscience Research Center, Kwangwoon University, Seoul 139-701, Korea
2
Department of Chemistry, Kwangwoon University, Seoul 139-701, Korea
*
Author to whom correspondence should be addressed.
Received: 2 August 2012 / Revised: 24 September 2012 / Accepted: 25 September 2012 / Published: 27 September 2012
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [517 KB, uploaded 18 June 2014]   |  

Abstract

Di(3-thienyl)methanol (2) and di(3-thienyl)methane (3) have been synthesized and screened against the T98G (brain cancer) cell line. Treatment induced cell death (MTT and macro-colony assay), growth inhibition, cytogenetic damage (micronuclei formation), were studied as cellular response parameters. Treatment with the compounds enhanced growth inhibition and cell death in a concentration dependent manner in both T98G and HEK (normal) cell lines. At higher concentrations (>20 µg/mL) the cytotoxic effects of the compounds were highly significant. The effect on clonogenic capacity and micronuclei formation observed after treatment of cells. Amongst the compounds, compound 2 exhibited potent activity against T98G brain cancer cells. Despite potent in vitro activity, both compounds exhibited less cytotoxicity against normal human HEK cells at all effective concentrations. View Full-Text
Keywords: thienyl derivatives; T98G gliomas; HEK cells thienyl derivatives; T98G gliomas; HEK cells
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kaushik, N.K.; Kim, H.S.; Chae, Y.J.; Lee, Y.N.; Kwon, G.-C.; Choi, E.H.; Kim, I.T. Synthesis and Anticancer Activity of Di(3-thienyl)methanol and Di(3-thienyl)methane. Molecules 2012, 17, 11456-11468.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top