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Molecules 2012, 17(10), 12187-12196; doi:10.3390/molecules171012187
Article

Synthesis and Herbicidal Activity of Substituted Pyrazole Isothiocyanates

1,2, 1,2, 3 and 1,2,*
1 Research & Development Center of Biorational Pesticide, Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Northwest A&F University, Yangling 712100, Shaanxi, China 2 Shaanxi Research Center of Biopesticide Engineering & Technology, Northwest A&F University, Yangling 712100, Shaanxi, China 3 Hubei Green-Tiandi Bioengineering Co., Ltd, Wuhan 430070, Hubei, China
* Author to whom correspondence should be addressed.
Received: 29 August 2012 / Revised: 8 October 2012 / Accepted: 9 October 2012 / Published: 17 October 2012
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Abstract

Isothiocyanates and substituted pyrazoles were combined to form a series of novel isothiocyanates with highly effective herbicidal activity. The target compounds were analyzed by elemental analysis, 1H-NMR, EI-MS and IR spectroscopy. The synthesized compounds, particularly compounds 3-1 and 3-7, exhibited good herbicidal activities against four weeds. The EC50 values of compound 3-1 against Echinochloa crusgalli L., Cyperus iria L., Dactylis glomerata L., and Trifolium repens L. were 64.32, 65.83, 62.42, and 67.72 µg/mL, respectively. The EC50 values of compound 3-7 against E. crusgalli L., C. iria L., D. glomerata L., T. repens L. were 65.33, 64.90, 59.41 and 67.41 µg/mL, respectively. Compounds 3-1 and 3-7 may be further optimized as lead compounds for new herbicides.
Keywords: substituted pyrazoles; isothiocyanates; synthesis; herbicidal activity substituted pyrazoles; isothiocyanates; synthesis; herbicidal activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Wu, H.; Feng, J.-T.; Lin, K.-C.; Zhang, X. Synthesis and Herbicidal Activity of Substituted Pyrazole Isothiocyanates. Molecules 2012, 17, 12187-12196.

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