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Molecules 2012, 17(11), 13175-13182; doi:10.3390/molecules171113175

Spiculisporic Acids B–D, Three New γ-Butenolide Derivatives from a Sea Urchin-Derived Fungus Aspergillus sp. HDf2

Hainan Provincial Fisheries Research Institute, Haikou 570203, Hainan, China
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Received: 18 October 2012 / Revised: 30 October 2012 / Accepted: 31 October 2012 / Published: 5 November 2012
(This article belongs to the Section Natural Products)
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Abstract

Three new γ-butenolide derivatives 13, named spiculisporic acids B–D, were isolated from the culture of Aspergillus sp. HDf2, a marine-derived fungus that resides in the sea urchin, Anthocidaris crassispina. The structures of 13 were elucidated on the basis of spectroscopic methods, including MS and 2D NMR techniques. Their in vitro cytotoxic activities against two cell lines (SGC-7901, human gastric adenocarcinoma and SPC-A-1, human lung adenocarcinoma) and inhibitory activities against Staphylococcus aureus ATCC 51650 were investigated.
Keywords: γ-butenolide derivatives; spiculisporic acids B–D; Aspergillus sp.; marine fungus γ-butenolide derivatives; spiculisporic acids B–D; Aspergillus sp.; marine fungus
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Wang, R.; Liu, T.-M.; Shen, M.-H.; Yang, M.-Q.; Feng, Q.-Y.; Tang, X.-M.; Li, X.-M. Spiculisporic Acids B–D, Three New γ-Butenolide Derivatives from a Sea Urchin-Derived Fungus Aspergillus sp. HDf2. Molecules 2012, 17, 13175-13182.

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