Next Article in Journal
Monoterpenoid Indole Alkaloids from Alstonia yunnanensis and Their Cytotoxic and Anti-inflammatory Activities
Previous Article in Journal
Organophosphorus Chemistry for the Synthesis of Dendrimers
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2012, 17(11), 13622-13630; doi:10.3390/molecules171113622

Amelioration of Dextran Sodium Sulfate-Induced Colitis in Mice by Rhodobacter sphaeroides Extract

1
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
2
Asia-Pacific Biotech Developing, Inc. Kaohsiung 806, Taiwan
3
Graduate Institute of Basic Medical Science, School of Medicine, China Medical University, Taichung 404, Taiwan
4
Department and Graduate Institute of Aquaculture, National Kaohsiung Marine University, Kaohsiung 404, Taiwan
5
Department of Microbiology, School of Medicine, China Medical University, Taichung 404, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 24 October 2012 / Revised: 13 November 2012 / Accepted: 14 November 2012 / Published: 16 November 2012
(This article belongs to the Section Natural Products)
Download PDF [1184 KB, uploaded 18 June 2014]

Abstract

Bacteria can produce some compounds in response to their environment. These compounds are widely used in cosmetic and pharmaceutical applications. Some probiotics have immunomodulatory activities and modulate the symptoms of several diseases. Autoimmune diseases represent a complex group of conditions that are thought to be mediated through the development of autoreactive immunoresponses. Inflammatory bowel disease (IBD) is common autoimmune disease that affects many individuals worldwide. Previously, we found that the extracts of Rhodobacter sphaeroides (Lycogen) inhibited nitric oxide production and inducible nitric-oxide synthase expression in activated macrophages. In this study, the effect of Lycogen™, a potent anti-inflammatory agent, was evaluated in mice with dextran sodium sulfate (DSS)-induced colitis. Oral administration of Lycogen™ reduced the expressions of proinflammatory cytokines (tumor necrosis factor-α and interleukin-1β) in female BABL/c mice. In addition, the increased number of bacterial flora in the colon induced by DSS was amelirated by Lycogen™. The histological score of intestinal inflammation in 5% DSS-treated mice after oral administration of Lycogen™ was lower than that of control mice. Meanwhile, Lycogen™ dramatically prolonged the survival of mice with severe colitis. These findings identified that Lycogen™ is an anti-inflammatory agent with the capacity to ameliorate DSS-induced colitis.
Keywords: Rhodobacter sphaeroides; Lycogen™; dextran sodium sulfate; colitis; inflammatory Rhodobacter sphaeroides; Lycogen™; dextran sodium sulfate; colitis; inflammatory
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Liu, W.-S.; Chen, M.-C.; Chiu, K.-H.; Wen, Z.-H.; Lee, C.-H. Amelioration of Dextran Sodium Sulfate-Induced Colitis in Mice by Rhodobacter sphaeroides Extract. Molecules 2012, 17, 13622-13630.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top