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Molecules 2012, 17(12), 14918-14927; doi:10.3390/molecules171214918

Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery

1
College of Pharmacy, Harbin Medical University, Harbin 150081, Heilongjiang, China
2
College of Pharmacy, Harbin Medical University-Daqing, Daqing 163319, Heilongjiang, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 22 October 2012 / Revised: 19 November 2012 / Accepted: 7 December 2012 / Published: 13 December 2012
(This article belongs to the Section Natural Products)
Download PDF [368 KB, 18 June 2014; original version 18 June 2014]

Abstract

Flowers of Carthamus tinctorius L. are traditionally used in China to treat cerebrovascular and cardiovascular diseases. Hydroxysafflor yellow A (HSYA), the main constituent of Carthamus tinctorius L. flowers, is known for its multiple biological activities. In the present study, HSYA was isolated from Carthamus tinctorius L. flowers by a macroporous resin adsorption chromatography method coupled with a Waters high-throughput auto-purification system and it's vasodilatation effects on pulmonary artery (PA) were explored by an assay of tension study on rat pulmonary artery (PA) rings. Results suggest that HSYA possesses vascular relaxation effects on rat PA by activating the KV channel in pulmonary vascular smooth muscle cells (PVSMCs).
Keywords: HSYA; Carthamus tinctorius L.; pulmonary arteries; vasodilatation HSYA; Carthamus tinctorius L.; pulmonary arteries; vasodilatation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Bai, Y.; Lu, P.; Han, C.; Yu, C.; Chen, M.; He, F.; Yi, D.; Wu, L. Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery. Molecules 2012, 17, 14918-14927.

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