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Molecules 2013, 18(10), 12740-12750; doi:10.3390/molecules181012740
Article

An Efficient and Facile Methodology for Bromination of Pyrimidine and Purine Nucleosides with Sodium Monobromoisocyanurate (SMBI)

*  and *
Department of Biosciences and Nutrition, Karolinska Institute (KI), Novum, Huddinge SE-141 83, Sweden
* Authors to whom correspondence should be addressed.
Received: 2 September 2013 / Revised: 2 October 2013 / Accepted: 9 October 2013 / Published: 15 October 2013
(This article belongs to the Special Issue Synthesis of Nucleosides, Nucleotides and Their Derivatives)
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Abstract

An efficient and facile strategy has been developed for bromination of nucleosides using sodium monobromoisocyanurate (SMBI). Our methodology demonstrates bromination at the C-5 position of pyrimidine nucleosides and the C-8 position of purine nucleosides. Unprotected and also several protected nucleosides were brominated in moderate to high yields following this procedure.
Keywords: bromination; sodium monobromoisocyanurate (SMBI); pyridine-based nucleosides; purine-based nucleosides; bromonucleosides bromination; sodium monobromoisocyanurate (SMBI); pyridine-based nucleosides; purine-based nucleosides; bromonucleosides
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Maity, J.; Stromberg, R. An Efficient and Facile Methodology for Bromination of Pyrimidine and Purine Nucleosides with Sodium Monobromoisocyanurate (SMBI). Molecules 2013, 18, 12740-12750.

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