Isosakuranetin-5-O-rutinoside: A New Flavanone with Antidepressant Activity Isolated from Salvia elegans Vahl.
Abstract
:1. Introduction
2. Results and Discussion
2.1. Evaluation of the Hydroalcoholic Extract
2.2. Chromatographic Separation of the Hydroalcoholic Extract and Isolation and Elucidation of Ursolic Acid (1) and a Flavanone 2
Treatment | Dose (mg/kg) | Immobility time |
---|---|---|
SeF1 | 250 | 96.2 ± 26.1 * |
F1-1 | 50.0 | 273.1 ± 12.1 |
F1-2 | 261.7 ± 19.6 | |
F1-3 | 113.8 ± 23.6 * | |
UA | 15.0 | 235.5 ± 1.9 |
30.0 | 221.2 ± 29.6 | |
SeF2 | 250.0 | 110.3 ± 21.0 * |
F2-1 | 50.0 | 286.5 ± 9.2 |
F2-2 | 241.8 ± 7.5 | |
Isosakuranetin-5- O-rutinoside | 15.0 | 122.0 ± 19.6 * |
IMI | 15.0 | 107.9 ± 23.4 * |
Veh (TW 20, 1%) | 100 µL/10 g | 230.2 ± 28.2 |
3. Experimental
3.1. General Experimental Procedures
3.2. Plant Material
3.3. Extraction and Isolation of Ursolic acid (1) and Isosakuranetin-5-O-Rutinoside (2)
3.4. Acetylation of Isosakuranetin-5-O-rutinoside (2)
3.5. Drugs
3.6. Animals and Drug Administration
3.7. Forced Swimming Test (FST)
3.8. Data Analysis
4. Conclusions
Supplementary Materials
Acknowledgments
Conflicts of Interest
References
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González-Cortazar, M.; Maldonado-Abarca, A.M.; Jiménez-Ferrer, E.; Marquina, S.; Ventura-Zapata, E.; Zamilpa, A.; Tortoriello, J.; Herrera-Ruiz, M. Isosakuranetin-5-O-rutinoside: A New Flavanone with Antidepressant Activity Isolated from Salvia elegans Vahl. Molecules 2013, 18, 13260-13270. https://doi.org/10.3390/molecules181113260
González-Cortazar M, Maldonado-Abarca AM, Jiménez-Ferrer E, Marquina S, Ventura-Zapata E, Zamilpa A, Tortoriello J, Herrera-Ruiz M. Isosakuranetin-5-O-rutinoside: A New Flavanone with Antidepressant Activity Isolated from Salvia elegans Vahl. Molecules. 2013; 18(11):13260-13270. https://doi.org/10.3390/molecules181113260
Chicago/Turabian StyleGonzález-Cortazar, Manáses, Ana María Maldonado-Abarca, Enrique Jiménez-Ferrer, Silvia Marquina, Elsa Ventura-Zapata, Alejandro Zamilpa, Jaime Tortoriello, and Maribel Herrera-Ruiz. 2013. "Isosakuranetin-5-O-rutinoside: A New Flavanone with Antidepressant Activity Isolated from Salvia elegans Vahl." Molecules 18, no. 11: 13260-13270. https://doi.org/10.3390/molecules181113260