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Molecules 2013, 18(2), 1477-1482; doi:10.3390/molecules18021477

Two New Derivatives of 2, 5-Dihydroxyphenylacetic Acid from the Kernel of Entada phaseoloides

1
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
2
Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study (No. BZ0150), Institute of Material Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
*
Authors to whom correspondence should be addressed.
Received: 14 January 2013 / Revised: 18 January 2013 / Accepted: 18 January 2013 / Published: 25 January 2013
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Abstract

Two new aromatic compounds, butyl 2,5-dihydroxyphenylacetate (1) and butyl 2-O-β-D-glucopyranosyloxy-5-dihydroxyphenylacetate (2), together with three known ones, methyl 2,5-dihydroxyphenylacetate (3), ethyl 2,5-dihydroxyphenylacetate (4) and 2-O-β-D-glucopyranosyloxy-5-hydroxyphenylacetic acid (5), were isolated from the EtOH extract of the kernel of Entada phaseoloides. The structures of the new compounds were elucidated by MS and NMR experiments. Compounds 1, 3 and 4 displayed potent inhibitory activities against HIV-1 replication, with EC50 values of 9.80 μM, 11.70 μM and 9.93 μM, respectively.
Keywords: Entada phaseoloides; Leguminosae; 2,5-dihydroxyphenylacetic acid; HIV-1 Entada phaseoloides; Leguminosae; 2,5-dihydroxyphenylacetic acid; HIV-1
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Chen, L.; Zhang, Y.; Ding, G.; Ba, M.; Guo, Y.; Zou, Z. Two New Derivatives of 2, 5-Dihydroxyphenylacetic Acid from the Kernel of Entada phaseoloides. Molecules 2013, 18, 1477-1482.

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