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Molecules 2013, 18(2), 1613-1625; doi:10.3390/molecules18021613

Microwave-Assisted Improved Synthesis of Pyrrolo[2,3,4-kl]acridine and Dihydropyrrolo[2,3,4-kl]acridine Derivatives Catalyzed by Silica Sulfuric Acid

1
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China
2
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union, Medical College, Beijing 100050, China
3
Center for Drug Evaluation, State Food and Drug Administration Office of Generic Drug Pharmaceutical Science, Beijing 100038, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 29 November 2012 / Revised: 21 December 2012 / Accepted: 5 January 2013 / Published: 28 January 2013
(This article belongs to the Section Organic Synthesis)
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Abstract

An improved synthesis of multifunctionalized pyrrolo[2,3,4-kl]acridine derivatives with different substituted patterns using silica sulfuric acid (SSA) as a heterogeneous catalyst under microwave irradiation conditions was developed. The reaction could be conducted by using readily available and inexpensive substrates within short periods of 12–15 min. under microwave irradiation. Compared with the conventional methods, the remarkable advantages of this method are milder reaction conditions, operational simplicity, higher yields, short reaction times, and an environmentally friendly procedure.
Keywords: pyrrolo[2,3,4-kl]acridine; silica sulfuric acid; microwave irradiation pyrrolo[2,3,4-kl]acridine; silica sulfuric acid; microwave irradiation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Cao, C.; Xu, C.; Lin, W.; Li, X.; Hu, M.; Wang, J.; Huang, Z.; Shi, D.; Wang, Y. Microwave-Assisted Improved Synthesis of Pyrrolo[2,3,4-kl]acridine and Dihydropyrrolo[2,3,4-kl]acridine Derivatives Catalyzed by Silica Sulfuric Acid. Molecules 2013, 18, 1613-1625.

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