Next Article in Journal
Effects of Adenosine Extract from Pholiota adiposa (Fr.) Quel on mRNA Expressions of Superoxide Dismutase and Immunomodulatory Cytokines
Previous Article in Journal
Microwave-Enhanced Cross-Coupling Reactions Involving Alkynyltrifluoroborates with Aryl Bromides
Molecules 2013, 18(2), 1762-1774; doi:10.3390/molecules18021762

Antioxidant Capacity of Two Novel Bioactive Fe(III)-Cyclophane Complexes

1, 1,2, 2, 2, 2, 3, 1,2,*  and 1,*
1 Departamento de Investigación en Polímeros y Materiales (DIPM), Universidad de Sonora, Calle Rosales y Blvd, Luis Encinas s/n, Col. Centro, PO Box 130. Hermosillo Sonora 83000, Mexico 2 Centro de Investigación en Alimentación y Desarrollo (CIAD), A.C. Carretera a Ejido La Victoria Km 0.6, PO Box 1735, Hermosillo Sonora 83304, Mexico 3 Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México (IBT-UNAM) Av. Universidad #2001, Col. Chamilpa, Cuernavaca, Morelos 62250, Mexico
* Authors to whom correspondence should be addressed.
Received: 13 November 2012 / Revised: 6 January 2013 / Accepted: 7 January 2013 / Published: 29 January 2013
Download PDF [919 KB, uploaded 18 June 2014]


The cyclophanes 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10, 24,27,30,33-octaaza-17,40-dioxa[]paracyclophane (PO) and 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10,24,27,30,33-octaaza[]paracyclophane (PC) were coordinated with iron to form cationic binuclear Fe(III) Fe2PO and Fe2PC complexes, respectively. Their antioxidant capacity, superoxide dismutase and peroxidase mimetic activity, as well as their toxicity toward peripheral blood mononuclear cells (PBMCs) were evaluated. Both Fe2PO and Fe2PC are interesting biomimetics with antioxidant capacity similar to that of ascorbic acid that prevent mortality in cultured PBMCs, with the potential to have bioactive and protective functions in disease animal models.
Keywords: cyclophane; macrocycle; iron; biomimetic; antioxidant cyclophane; macrocycle; iron; biomimetic; antioxidant
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Salazar-Medina, A.J.; Sugich-Miranda, R.; Teran-Cabanillas, E.; Hernández, J.; González-Aguilar, G.A.; Rudiño-Piñera, E.; Sotelo-Mundo, R.R.; Velázquez-Contreras, E.F. Antioxidant Capacity of Two Novel Bioactive Fe(III)-Cyclophane Complexes. Molecules 2013, 18, 1762-1774.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert