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Molecules 2013, 18(2), 2052-2060; doi:10.3390/molecules18022052

Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model

1
Department of Chemistry, Tamkang University, 151, Yingzhuan Road, Danshui Dist., New Taipei City 25137, Taiwan
2
Division of Basic Research, Koo Foundation Sun Yat-Sen Cancer Center, Taipei 11259, Taiwan
3
Department of Mathematics, Tamkang University, Danshui Dist., New Taipei City 25137, Taiwan
4
Department of Applied Chemistry, National Chia-Yi University, Chia-Yi 60004, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 18 December 2012 / Revised: 29 January 2013 / Accepted: 29 January 2013 / Published: 5 February 2013
(This article belongs to the Section Medicinal Chemistry)
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Abstract

The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line “Tg(mpx:gfp)” to visualize the effect of neutrophil recruitment dynamically. Results showed that treatment with compound 9 not only affected wound-induced neutrophil recruitment, but also affected Mpx enzymatic activity. Moreover, protein expression levels of pro-inflammatory factors (Mpx, NFκB, and TNFα) were also regulated by compound 9. Taken together, our results provide in vivo evidence of the anti-inflammatory effects of synthesized chalcone analogues on wound-induced inflammation.
Keywords: anti-inflammation; chalcone; fin; zebrafish anti-inflammation; chalcone; fin; zebrafish
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MDPI and ACS Style

Chen, Y.-H.; Wang, W.-H.; Wang, Y.-H.; Lin, Z.-Y.; Wen, C.-C.; Chern, C.-Y. Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model. Molecules 2013, 18, 2052-2060.

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