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Molecules 2013, 18(5), 5051-5058; doi:10.3390/molecules18055051

Sesquiterpenoids from the Herb of Leonurus japonicus

1
State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China
2
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China
3
Chengdu No.1 Pharmaceuticlco. Ltd., Chengdu 610031, Sichuan, China
*
Authors to whom correspondence should be addressed.
Received: 10 April 2013 / Revised: 24 April 2013 / Accepted: 25 April 2013 / Published: 29 April 2013
(This article belongs to the Section Natural Products)
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Abstract

Two new sesquiterpenoids, (−)-(1S*,2S*,3R*)-3-ethoxycupar-5-ene-1,2-diol (1) and (−)-(1S*,4S*,9S*)-1,9-epoxybisabola-2,10-diene-4-ol (2), along with six known compounds 38, were isolated from the EtOH extract of the herb of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. In the in vitro assays, compounds 7 and 8 showed obvious antibacterial activity against several bacteria strains, while compound 3 significantly inhibited abnormal increase of platelet aggregation induced by ADP. View Full-Text
Keywords: Leonurus japonicus; sesquiterpenoids; bioactivities Leonurus japonicus; sesquiterpenoids; bioactivities
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Xiong, L.; Zhou, Q.-M.; Peng, C.; Xie, X.-F.; Guo, L.; Li, X.-H.; Liu, J.; Liu, Z.-H.; Dai, O. Sesquiterpenoids from the Herb of Leonurus japonicus. Molecules 2013, 18, 5051-5058.

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