Molecules 2013, 18(5), 5306-5316; doi:10.3390/molecules18055306
Isolation of Nematicidal Triterpenoid Saponins from Pulsatilla koreana Root and Their Activities against Meloidogyne incognita
1
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea
2
Technical Research Institute, Dongbang Agro Co., LTD, Buyeo, Chungnam 323-932, Korea
*
Author to whom correspondence should be addressed.
Received: 18 April 2013 / Revised: 6 May 2013 / Accepted: 7 May 2013 / Published: 8 May 2013
(This article belongs to the Section Natural Products)
Abstract
Pulsatilla koreana, a species endemic to Korea, is an important herb used in traditional medicine to treat amoebic dysentery and malaria. In the present study, 23 oleanane-type triterpenoid saponins 1–23 and eight lupane-type triterpenoid saponins 24–31 were isolated from the roots of P. koreana. Their structures were elucidated on the basis of spectroscopic data. The methanol extract and isolated compounds were next assessed for nematicidal activity against the root-knot nematode (Meloidogyne incognita). The methanol extract showed strong nematicidal activity after 48 h, with a LC50 value of 92.8 μg/mL. Compounds 2, 5, 9, 20, and 21 showed significant effects, with LC50 values ranging from 70.1 to 94.7 μg/mL after 48 h. These results suggest that triterpenoid saponins from P. koreana should be explored as potential natural nematicides for developing new agents to control root-knot nematode disease View Full-Text
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Li, W.; Sun, Y.N.; Yan, X.T.; Yang, S.Y.; Lee, S.J.; Byun, H.J.; Moon, C.S.; Han, B.S.; Kim, Y.H. Isolation of Nematicidal Triterpenoid Saponins from Pulsatilla koreana Root and Their Activities against Meloidogyne incognita. Molecules 2013, 18, 5306-5316.
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