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Molecules 2013, 18(6), 7323-7335; https://doi.org/10.3390/molecules18067323

Herb-Drug Interaction of Epimedium sagittatum (Sieb. et Zucc.) Maxim Extract on the Pharmacokinetics of Sildenafil in Rats

1
Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan
2
Department of Urology, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan
3
Department of Education and Research, Taipei City Hospital, Taipei 10341, Taiwan
4
National Research Institute of Chinese Medicine, Taipei 11221, Taiwan
5
Institute of Microbiology and Immunology, National Yang-Ming University, Taipei 11221, Taiwan
6
Graduate Institute of Acupuncture Science, China Medical University, Taichung 40402, Taiwan
*
Author to whom correspondence should be addressed.
Received: 9 April 2013 / Revised: 16 May 2013 / Accepted: 19 June 2013 / Published: 21 June 2013
(This article belongs to the Section Natural Products Chemistry)
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Abstract

Epimedium sagittatum (Sieb. et Zucc.) Maxim is one of the herbs used to treat erectile dysfunction in Traditional Chinese Medicine. Sildenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction in Western Medicine. This study evaluates the herbal-drug interaction of Epimedium sagittatum extract on the pharmacokinetics of sildenafil in rats by ultra-performance liquid chromatography. The rat plasma was sampled from each anesthetized rat after pretreatment with 3-days Epimedium sagittatum extract (1/2 g/kg/day) and intravenous injection with sildenafil (10/30 mg/kg). The pharmacokinetic data demonstrate that the area under the concentration-time curve (AUC) of sildenafil (10 mg/kg) was significantly decreased in groups that received a high dose of Epimedium sagittatum extract. In conclusion, the study demonstrates that there was significant herb-drug interaction of Epimedium sagittatum extract on the pharmacokinetics of sildenafil at low and high daily doses, suggesting co-administration use of Epimedium sagittatum extract and sildenafil in clinical practice should be prevented due to possible herb-drug interactions. View Full-Text
Keywords: sildenafil; Epimedium sagittatum extract; herb-drug interaction; Traditional Chinese Medicine sildenafil; Epimedium sagittatum extract; herb-drug interaction; Traditional Chinese Medicine
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Hsueh, T.Y.; Wu, Y.-T.; Lin, L.-C.; Chiu, A.W.; Lin, C.-H.; Tsai, T.-H. Herb-Drug Interaction of Epimedium sagittatum (Sieb. et Zucc.) Maxim Extract on the Pharmacokinetics of Sildenafil in Rats. Molecules 2013, 18, 7323-7335.

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