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Molecules 2013, 18(8), 9163-9178; doi:10.3390/molecules18089163

Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum

1
School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China
2
Jiangshu Alpha Biopharmaceuticals, Inc., Wuxi 214122, China
3
Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, Jiangsu Institute of Parasitic Diseases, Wuxi 214064, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 25 June 2013 / Revised: 24 July 2013 / Accepted: 25 July 2013 / Published: 31 July 2013
(This article belongs to the Section Medicinal Chemistry)
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Abstract

The synthesis and structure-activity relationship (SAR) studies of praziquantel derivatives with activity against adult Schistosoma japonicum are described. Several of them showed better worm killing activity than praziquantel and could serve as leads for further optimization.
Keywords: praziquantel derivatives; antischistosomal activity; Schistosoma japonicum; neglected tropical disease praziquantel derivatives; antischistosomal activity; Schistosoma japonicum; neglected tropical disease
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Wang, W.-L.; Song, L.-J.; Chen, X.; Yin, X.-R.; Fan, W.-H.; Wang, G.-P.; Yu, C.-X.; Feng, B. Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum. Molecules 2013, 18, 9163-9178.

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