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Molecules 2013, 18(8), 9670-9683; doi:10.3390/molecules18089670

The Emerging Role of Ferumoxytol-Enhanced MRI in the Management of Cerebrovascular Lesions

1 Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA 19107, USA 2 Department of Neurosurgery, University of Iowa, Iowa City, IA 52242, USA
* Author to whom correspondence should be addressed.
Received: 14 June 2013 / Accepted: 8 August 2013 / Published: 13 August 2013
(This article belongs to the Special Issue Contrast Agents)
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Inflammation is increasingly being understood to be a key component to the pathophysiology of cerebrovascular lesions. Ferumoxytol, an iron oxide nanoparticle coated by a carbohydrate shell, has been used in MRI studies as an inflammatory marker because it is cleared by macrophages. Ferumoxytol-enhanced MRI has emerged as an important tool for noninvasive assessment of the inflammatory status of cerebrovascular lesions, namely aneurysms and arteriovenous malformations. Moreover, preliminary evidence suggests that ferumoxytol-enhanced MRI could be applied as a non-invasive tool to differentiate “unstable” lesions that require early intervention from “stable” lesions in which observation may be safe. Assessment of the effects of anti-inflammatory pharmacological interventions on cerebrovascular lesions is also a potentially crucial application of the technique. Future improvements in technique and MRI signal quantification will certainly pave the way for widespread and efficient use of ferumoxytol-enhanced MRI in clinical practice. In this paper, we review current data regarding ferumoxytol-enhanced MRI and discuss its current/potential applications and future perspectives.
Keywords: aneurysm; ferumoxytol; arteriovenous malformation; magnetic resonance imaging; inflammation aneurysm; ferumoxytol; arteriovenous malformation; magnetic resonance imaging; inflammation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Chalouhi, N.; Jabbour, P.; Magnotta, V.; Hasan, D. The Emerging Role of Ferumoxytol-Enhanced MRI in the Management of Cerebrovascular Lesions. Molecules 2013, 18, 9670-9683.

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