Special Issue "Contrast Agents"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (30 June 2013)
Prof. Dr. Angelique Louie (Website)
Department of Biomedical Engineering, University of California Davis, CA 95616, USA
Fax: +1 530 754 5739
Interests: molecular imaging; cellular imaging; development of diagnostic and therapeutic agents; magnetic resonance imaging; novel contrast agents; fluorescence microscopy; multimodal imaging and imaging agents
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Review
Title: Strategies for Optimizing Water-exchange Rates of Contrast Agents for Magnetic Resonance Imaging
Authors: Buddhima N. Siriwardena-Mahanama and Matthew J. Allen
Affiliation: Department of Chemistry, Wayne State University, 42 W Warren Ave, Detroit, MI 48202, USA
Abstract: This review describes recent advances in tuning water-exchange rates of contrast agents for magnetic resonance imaging (MRI).
Water-exchange rate plays a critical role in determining the efficiency of contrast agents; consequently, optimization of water-exchange rates, among other parameters, of contrast agents is necessary to achieve high efficiencies. This need has resulted in extensive research efforts to
modulate water-exchange rates by chemically altering the coordination environments of the metal complexes that function as contrast agents. The focus of this review is coordination-chemistry-based strategies used to tune the water-exchange rates of metal-based contrast agents for MRI. Emphasis will be given to results published in the 21st century as well as the implications of these strategies on the future design of contrast agents.
Type of Paper: Review
Title: The Emerging Role of Ferumoxytol-Enhanced MRI in Cerebrovascular Disease
Authors: Nohra Chalouhi 2, Pascal Jabbour 2, Vincent Magnotta 1 and David Hasan 1
Affiliations: 1 Department of Neurosurgery, University of Iowa, Iowa City, Iowa, USA
2 Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania, USA
Abstract: Inflammation is increasingly being understood to be a key component to the pathophysiology of cerebrovascular lesions. Ferumoxytol, an iron oxide nanoparticle coated by a carbohydrate shell, has been used in MRI studies as an inflammatory marker because it is cleared by macrophages. Ferumoxytol-enhanced MRI has emerged as an important tool for noninvasive assessment of the inflammatory status of cerebrovascular lesions, namely aneurysms and arteriovenous malformations. Moreover, preliminary evidence suggests that ferumoxytol-enhanced MRI could be applied as a non-invasive tool to differentiate “unstable” lesions that require early intervention from “stable” lesions in which observation may be safe. Assessment of the effects of anti-inflammatory pharmacological interventions on cerebrovascular lesions is also a potentially crucial application of the technique. Future improvements in technique and MRI signal quantification will certainly pave the way for widespread and efficient use of ferumoxytol-enhanced MRI in clinical practice. In this paper, we review current data regarding ferumoxytol-enhanced MRI and discuss its potential applications, technical aspects, and future perspectives.
Type of Paper: Review
Title: Responsive Particulate MRI Contrast Agents: Design Principles and Applications
Authors: Valerie C. Pierre* and Lindsay Rymes
Affiliation: Department of Chemistry, University of Minnesota, Twin Cities, MN, USA
Abstract: Due to their high relaxivities and low toxicity, iron oxide nanoparticles have found increasing use as contrast agents for Magnetic Resonance Imaging. A decade ago, Weissleder and Josephson first reported the possibility to use the reversible aggregation of such magnetic nanoparticles for the detection of targeted biomarkers via changes in both longitudinal and transverse relaxivities. Since then, magnetic switches have been developed to report on a variety of substrates including enzymes, proteins, nucleic acids, metals, pH, and small molecules. The principles of nanoparticle magnetism which is at the basis for this responsive behavior and the parameters of the nanoparticles that affect their sensitivity and response are described. The advantages and limitations of this class of smart contrast agents are highlighted through a survey of literature examples.