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Molecules 2014, 19(1), 550-567; doi:10.3390/molecules19010550

[15]aneN4S: Synthesis, Thermodynamic Studies and Potential Applications in Chelation Therapy

Instituto de Investigação do Medicamento (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisboa 1649-003, Portugal
CBIOS, Universidade Lusófona Research Center in Biosciences & Health Technologies, Campo Grande 376, Lisboa 1749-024, Portugal
CQE, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, Lisboa 1049-001, Portugal
DQB, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, Lisboa 1749-001, Portugal
These authors contributed equally to the senior authorship.
Author to whom correspondence should be addressed.
Received: 2 December 2013 / Revised: 23 December 2013 / Accepted: 24 December 2013 / Published: 3 January 2014
(This article belongs to the Special Issue Macrocyclic Chemistry)
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The purpose of this work was to synthesize and characterize the thiatetraaza macrocycle 1-thia-4,7,10,13-tetraazacyclopentadecane ([15]aneN4S). Its acid-base behaviour was studied by potentiometry at 25 °C and ionic strength 0.10 M in KNO3. The protonation sequence of this ligand was investigated by 1H-NMR titration that also allowed the determination of protonation constants in D2O. Binding studies of [15]aneN4S with Mn2+, Fe2+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Hg2+ and Pb2+ metal ions were further performed under the same experimental conditions. The results demonstrated that this compound has a higher selectivity and thermodynamic stability for Hg2+ and Cu2+, followed by Ni2+. The UV-visible-near IR spectroscopies and magnetic moment data for the Co(II) and Ni(II) complexes indicated a tetragonal distorted coordination geometry for both metal centres. The value of magnetic moment and the X-band EPR spectra of the Cu(II) complex are consistent with a distorted square pyramidal geometry. View Full-Text
Keywords: macrocyclic compounds; thiatetraaza; stability constants; spectroscopic studies; chelation therapy; mercury(II) chelator; copper(II) chelator macrocyclic compounds; thiatetraaza; stability constants; spectroscopic studies; chelation therapy; mercury(II) chelator; copper(II) chelator

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Torres, N.; Gonçalves, S.; Fernandes, A.S.; Machado, J.F.; de Brito, M.J.V.; Oliveira, N.G.; Castro, M.; Costa, J.; Cabral, M.F. [15]aneN4S: Synthesis, Thermodynamic Studies and Potential Applications in Chelation Therapy. Molecules 2014, 19, 550-567.

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