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Molecules, Volume 2, Issue 9 (September 1997), Pages 129-151, Article M26

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Open AccessArticle Improved Method for the Synthesis of New 1,5-Benzothiazepine Derivatives as Analogues of Anticancer Drugs
Molecules 1997, 2(9), 129-134; doi:10.3390/20900129
Received: 10 April 1997 / Accepted: 1 August 1997 / Published: 5 September 1997
Cited by 4 | PDF Full-text (26 KB)
Abstract (±)cis-2-(4-Methoxyphenyl)-3-hydroxy/methoxy-2,3-dihydro-1,5-benzothiazepin-4[5H/5-chloroacetyl/5-(4'-methylpiperazino-1')acetyl]-ones have been synthesized by the condensation of 2-aminobenzene thiols with methyl(±)trans-3-(4-methoxyphenyl)glycidate in xylene. The synthesized compounds have been characterized by elemental analyses and spectral data and screened for their antimicrobial activity. Full article
Open AccessArticle Photoisomerization of Ethyl 2–(3–Acylselenoureido)thiophene– 3–carboxylates and Their Benzoanalogues
Molecules 1997, 2(9), 135-151; doi:10.3390/20900135
Received: 6 January 1997 / Accepted: 24 May 1997 / Published: 15 September 1997
Cited by 3 | PDF Full-text (199 KB)
Abstract
Synthesis, isomerisation and structure elucidation of the title compounds 1–6 and its isomers 7–12 by FTIR, 1H, 13C, 15N, 77Se NMR spectroscopy is reported. Ethyl 2–(3–acylselenoureido)thiophene–3–carboxylates and their benzoanalogues (where acyl is benzoyl and pivaloyl) were prepared by [...] Read more.
Synthesis, isomerisation and structure elucidation of the title compounds 1–6 and its isomers 7–12 by FTIR, 1H, 13C, 15N, 77Se NMR spectroscopy is reported. Ethyl 2–(3–acylselenoureido)thiophene–3–carboxylates and their benzoanalogues (where acyl is benzoyl and pivaloyl) were prepared by addition of ethyl 2–aminothiophene–3–carboxylates and ethyl 2–aminobenzoate on benzoyl– or pivaloylisoselenocyanate in acetone solution. An isomerization of 1–6 to the corresponding 3–acylisoselenoureas 7–12 was obtained. The isomerisation proceeds either by irradiation with light (340–400 nm) or in the case of benzoylderivatives 1, 3, 5 by treatment with acetic acid. On the other hand the acid action in the pivaloyl set inhibited this isomerisation and evoked the retroisomerisation reaction of 8, 10, 12 to 2, 4, 6. Thermal analyses showed that isomerisation can be initiated also by heating. These changes proceed in the solid phase as an exothermic process at an elevated temperature but always below the temperature of melting. The structure 2 was supported by X–ray analysis. Molecular design of 2 and 8 was modeled during application of ab initio quantum chemistry calculation. Full article

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Open AccessShort Note 3,3-Bis(5-methylfur-2-yl)-2-oxoindoline
Molecules 1997, 2(9), M26; doi:10.3390/M26
Received: 2 September 1997 / Published: 22 September 1997
PDF Full-text (70 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

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