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Molecules 2017, 22(3), 476; doi:10.3390/molecules22030476

Analysis of Chemical Constituents of Melastoma dodecandrum Lour. by UPLC-ESI-Q-Exactive Focus-MS/MS

1
Beijing Key Laboratory for Quality Evaluation of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China
2
National Center for Natural Products Research, Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, Oxford, MS 38677, USA
3
Dongying Inspection Center for Food and Drug, Dongying 257091, Shandong, China
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas J. Schmidt
Received: 8 December 2016 / Revised: 13 March 2017 / Accepted: 16 March 2017 / Published: 17 March 2017
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Abstract

The ethnic drug Melastoma dodecandrum Lour. (MDL) is widely distributed throughout South China, and is the major component of Gong Yan Ping Tablets/Capsules and Zi Di Ning Xue San. Although the pharmacological effects of MDL have been well documented, its chemical profile has not been fully determined. In this study, we have developed a rapid and sensitive UPLC-ESI-Q-Exactive Focus-MS/MS method to characterize the chemical constituents of MDL in the positive and negative ionization modes. A comparison of the chromatographic and spectrometric data obtained using this method with data from databases, the literature and reference standards allowed us to identify or tentatively characterize 109 compounds, including 26 fatty acids, 26 organic acids, 33 flavonoids, six tannins, 10 triterpenoids, two steroids and six other compounds. Notably, 55 of the compounds characterized in this study have never been detected before in this plant. The information obtained in this study therefore enriches our understanding of the chemical composition of MDL and could be used in quality control, pharmacological research and the development of drugs based on MDL. In addition, this study represents the first reported comprehensive analysis of the chemical constituents of MDL. View Full-Text
Keywords: Melastoma dodecandrum Lour.; ultra performance liquid chromatography; mass spectrometry; chemical constituents; identification Melastoma dodecandrum Lour.; ultra performance liquid chromatography; mass spectrometry; chemical constituents; identification
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MDPI and ACS Style

Wang, J.; Jia, Z.; Zhang, Z.; Wang, Y.; Liu, X.; Wang, L.; Lin, R. Analysis of Chemical Constituents of Melastoma dodecandrum Lour. by UPLC-ESI-Q-Exactive Focus-MS/MS. Molecules 2017, 22, 476.

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