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Molecules 2017, 22(4), 652; doi:10.3390/molecules22040652

Modification of Natural Eudesmane Scaffolds via Mizoroki-Heck Reactions

1
Institut de Chimie Organique et Analytique, University d’Orléans, UMR CNRS 7311, B.P. 6759, 45067 Orléans CEDEX 2, France
2
Laboratoire de Chimie Physique & Chimie Bioorganique, Département de chimie, URA C 22, Pôle RéPAM, F. S. T. University Hassan II de Casablanca, B.P. 146 Yasmina, 28800 Mohammedia, Morocco
*
Author to whom correspondence should be addressed.
Academic Editor: Isabel C.F.R. Ferreira
Received: 3 March 2017 / Revised: 4 April 2017 / Accepted: 5 April 2017 / Published: 20 April 2017
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [4022 KB, uploaded 20 April 2017]   |  

Abstract

The Mizoroki-Heck reaction was applied to substrates derived from isocostic and ilicic acids, important sesquiterpene components of Dittrichia viscosa L. Greuter that were extracted directly from plant material collected in Morocco. After optimization of the metallo-catalysis conditions, various aryl-groups were successfully introduced on the exocyclic double bond with an exclusive E-configuration and without racemization. View Full-Text
Keywords: eudesmane; isocostic and ilicic acids; Dittrichia viscosa L. Greuter; sesquiterpenes; Mizoroki-Heck reaction eudesmane; isocostic and ilicic acids; Dittrichia viscosa L. Greuter; sesquiterpenes; Mizoroki-Heck reaction
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zaki, M.; Akssira, M.; Berteina-Raboin, S. Modification of Natural Eudesmane Scaffolds via Mizoroki-Heck Reactions. Molecules 2017, 22, 652.

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