Design, Synthesis, and Safener Activity of Novel Methyl (R)-N-Benzoyl/Dichloroacetyl-Thiazolidine-4-Carboxylates
AbstractA series of novel methyl (R)-N-benzoyl/dichloroacetyl-thiazolidine-4-carboxylates were designed by active substructure combination. The title compounds were synthesized using a one-pot route from l-cysteine methyl ester hydrochloride, acyl chloride, and ketones. All compounds were characterized by IR, 1H NMR, 13C NMR, and HRMS. The structure of 4q was determined by X-ray crystallography. The biological tests showed that the title compounds protected maize from chlorimuron-ethyl injury to some extent. The ALS activity assay showed that the title compounds increased the ALS activity of maize inhibited by chlorimuron-ethyl. Molecular docking modeling demonstrated that Compound 4e competed against chlorimuron-ethyl to combine with the herbicide target enzyme active site, causing the herbicide to be ineffective. View Full-Text
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Zhao, L.-X.; Wu, H.; Zou, Y.-L.; Wang, Q.-R.; Fu, Y.; Li, C.-Y.; Ye, F. Design, Synthesis, and Safener Activity of Novel Methyl (R)-N-Benzoyl/Dichloroacetyl-Thiazolidine-4-Carboxylates. Molecules 2018, 23, 155.
Zhao L-X, Wu H, Zou Y-L, Wang Q-R, Fu Y, Li C-Y, Ye F. Design, Synthesis, and Safener Activity of Novel Methyl (R)-N-Benzoyl/Dichloroacetyl-Thiazolidine-4-Carboxylates. Molecules. 2018; 23(1):155.Chicago/Turabian Style
Zhao, Li-Xia; Wu, Hao; Zou, Yue-Li; Wang, Qing-Rui; Fu, Ying; Li, Chun-Yan; Ye, Fei. 2018. "Design, Synthesis, and Safener Activity of Novel Methyl (R)-N-Benzoyl/Dichloroacetyl-Thiazolidine-4-Carboxylates." Molecules 23, no. 1: 155.
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