Next Article in Journal
Synthesis, Structural Studies and Biological Evaluation of Connections of Thiosemicarbazide, 1,2,4-Triazole and 1,3,4-Thiadiazole with Palmitic Acid
Previous Article in Journal
Effect of Red and Blue Light on Anthocyanin Accumulation and Differential Gene Expression in Strawberry (Fragaria × ananassa)
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 23
Issue 4
10.3390/molecules23040821
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Synthesis of Novel C-2- or C-15-Labeled BODIPY—Estrone Conjugates

by
Ildikó Bacsa
1,
Csilla Konc
1,
Anna Boglárka Orosz
1,
Gábor Kecskeméti
2,
Réka Rigó
3,
Csilla Özvegy-Laczka
3 and
Erzsébet Mernyák
1,*
1
Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary
2
Department of Medicinal Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary
3
Membrane protein research group, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, H-1117 Budapest, Hungary
*
Author to whom correspondence should be addressed.
Molecules 2018, 23(4), 821; https://doi.org/10.3390/molecules23040821
Submission received: 6 March 2018 / Revised: 29 March 2018 / Accepted: 2 April 2018 / Published: 3 April 2018
(This article belongs to the Section Organic Chemistry)
Browse Figures
Versions Notes

Abstract

Novel BODIPY–estrone conjugates were synthesized via Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC). Estrone-alkynes or an estrone-azide as starting compounds were synthesized via Michael addition or Sonogashira reaction as key steps. Fluorescent dyes based on BODIPY-core were provided by azide or alkyne functional groups. Fluorescent labeling of estrone was efficiently achieved at the C-2 or C-15 position. The newly-elaborated coupling procedures might have a broad applicability in the synthesis of fluorescent-labeled estrone conjugates suitable for biological assays.
Keywords: BODIPY; estrone; CuAAC; fluorescent labeling; estrone conjugates BODIPY; estrone; CuAAC; fluorescent labeling; estrone conjugates
Graphical Abstract

Share and Cite

MDPI and ACS Style

Bacsa, I.; Konc, C.; Orosz, A.B.; Kecskeméti, G.; Rigó, R.; Özvegy-Laczka, C.; Mernyák, E. Synthesis of Novel C-2- or C-15-Labeled BODIPY—Estrone Conjugates. Molecules 2018, 23, 821. https://doi.org/10.3390/molecules23040821

AMA Style

Bacsa I, Konc C, Orosz AB, Kecskeméti G, Rigó R, Özvegy-Laczka C, Mernyák E. Synthesis of Novel C-2- or C-15-Labeled BODIPY—Estrone Conjugates. Molecules. 2018; 23(4):821. https://doi.org/10.3390/molecules23040821

Chicago/Turabian Style

Bacsa, Ildikó, Csilla Konc, Anna Boglárka Orosz, Gábor Kecskeméti, Réka Rigó, Csilla Özvegy-Laczka, and Erzsébet Mernyák. 2018. "Synthesis of Novel C-2- or C-15-Labeled BODIPY—Estrone Conjugates" Molecules 23, no. 4: 821. https://doi.org/10.3390/molecules23040821

APA Style

Bacsa, I., Konc, C., Orosz, A. B., Kecskeméti, G., Rigó, R., Özvegy-Laczka, C., & Mernyák, E. (2018). Synthesis of Novel C-2- or C-15-Labeled BODIPY—Estrone Conjugates. Molecules, 23(4), 821. https://doi.org/10.3390/molecules23040821

Article Metrics

Back to TopTop