Eudesmane and Eremophilane Sesquiterpenes from the Fruits of Alpinia oxyphylla with Protective Effects against Oxidative Stress in Adipose-Derived Mesenchymal Stem Cells
Abstract
:1. Introduction
2. Results and Discussion
2.1. Structure Elucidation
2.2. Biological Activities of Isolated Compounds on ADMSCs
3. Materials and Methods
3.1. General Procedures
3.2. Plant Materials
3.3. Extraction and Isolation
3.4. Culture of Mouse ADMSCs
3.5. Effect of Isolated Compounds on the Viability of tBHP-Damaged ADMSCs
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Informed Consent Statement
Acknowledgments
Conflicts of Interest
Sample Availability
References
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1 | 2 | 3 | |
---|---|---|---|
Position | δH, mult (J in Hz). | δH, mult (J in Hz) | δH, mult (J in Hz) |
1α | 2.30, dd (16.2, 1.3) | 2.26, s | 5.84, d (1.5) |
1β | 2.14, dd (16.2, 1.3) | ||
2 | |||
3 | 5.90, dt (2.9, 1.3) | 5.90, dq (2.9, 1.4) | 4.39, dd (5.3, 2.2) |
4 | 2.03, dd (7.1, 5.3) | ||
5 | 2.37, m | 2.83, ddq (13.2, 2.9, 1.4) | |
6α | 1.54, m | 1.55, dd (14.0, 13.2) | 1.76, m |
6β | 2.41, m | 2.34, dt (14.0, 2.9) | 1.81, t (12.3) |
7 | 2.59, m | ||
8α | 1.78, td (14.1, 4.1) | 1.71, m | 2.07, m |
8β | 2.19, m | 1.91, m | 1.32, dd (13.1, 4.5) |
9α | 1.53, m | 1.34, m | 2.55, tdd (12.9, 4.5, 1.5) |
9β | 1.42, td (13.9, 4.1) | 1.72, m | 2.29, ddd (12.9, 4.5, 2.7) |
10 | |||
11 | |||
12a | 5.37, t (1.3) | 5.08, brs | 4.75, t (1.5) |
12b | 5.21, brs | 5.04, t (1.4) | 4.72, brs |
13 | 1.84, brs | 1.84, m | 1.72, brs |
14 | 0.96, brs | 0.89, brs | 1.28, brs |
15 | 1.93, t (1.3) | 1.91, t (1.4) | 0.92, d (7.1) |
OH | 3.26, d (2.2) |
1 | 2 | 3 | |
---|---|---|---|
Position | δC, type | δC, type | δC, type |
1 | 54.1, CH2 | 54.0, CH2 | 119.6, CH |
2 | 198.9, C | 199.5, C | 199.8, C |
3 | 127.2, CH | 127.1, CH | 73.4, CH |
4 | 162.0, C | 163.7, C | 44.0, CH |
5 | 44.5, CH | 42.4, CH | 41.3, C |
6 | 28.7, CH2 | 28.5, CH2 | 43.7, CH2 |
7 | 86.7, C | 85.1, C | 40.1, CH |
8 | 26.7, CH2 | 27.2, CH2 | 34.6, CH2 |
9 | 37.2, CH2 | 35.2, CH2 | 33.1, CH2 |
10 | 37.9, C | 37.2, C | 170.7, C |
11 | 141.5, C | 147.8, C | 148.3, C |
12 | 118.5, CH2 | 112.5, CH2 | 109.9, CH2 |
13 | 18.9, CH3 | 18.9, CH3 | 21.1, CH3 |
14 | 22.1, CH3 | 22.0, CH3 | 9.0, CH3 |
15 | 17.0, CH3 | 16.2, CH3 | 22.7, CH3 |
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Thapa, P.; Lee, Y.J.; Nguyen, T.T.; Piao, D.; Lee, H.; Han, S.; Lee, Y.J.; Han, A.-R.; Choi, H.; Jeong, J.-H.; et al. Eudesmane and Eremophilane Sesquiterpenes from the Fruits of Alpinia oxyphylla with Protective Effects against Oxidative Stress in Adipose-Derived Mesenchymal Stem Cells. Molecules 2021, 26, 1762. https://doi.org/10.3390/molecules26061762
Thapa P, Lee YJ, Nguyen TT, Piao D, Lee H, Han S, Lee YJ, Han A-R, Choi H, Jeong J-H, et al. Eudesmane and Eremophilane Sesquiterpenes from the Fruits of Alpinia oxyphylla with Protective Effects against Oxidative Stress in Adipose-Derived Mesenchymal Stem Cells. Molecules. 2021; 26(6):1762. https://doi.org/10.3390/molecules26061762
Chicago/Turabian StyleThapa, Punam, Yoo Jin Lee, Tiep Tien Nguyen, Donglan Piao, Hwaryeong Lee, Sujin Han, Yeon Jin Lee, Ah-Reum Han, Hyukjae Choi, Jee-Heon Jeong, and et al. 2021. "Eudesmane and Eremophilane Sesquiterpenes from the Fruits of Alpinia oxyphylla with Protective Effects against Oxidative Stress in Adipose-Derived Mesenchymal Stem Cells" Molecules 26, no. 6: 1762. https://doi.org/10.3390/molecules26061762