Reduction and Preparation of a Phthalimide Derivative from a Furo-heliangolide
Abstract
:Introduction
Results and Discussion
H | 3 | 4 | δ(4) - δ(3) |
---|---|---|---|
5α | 2.14 | 2.44 | 0.30 |
4 | 3.33 | 3.10 | -0.23 |
5β | 2.35 | 2.14 | -0.21 |
7 | 3.06 | 3.26 | 0.20 |
2 | 5.70 | 5.89 | 0.19 |
15a | 3.85 | 3.99 | 0.14 |
15b | 3.80 | 3.93 | 0.13 |
8 | 4.93 | 5.01 | 0.08 |
9β | 2.07 | 2.10 | 0.03 |
6 | 4.23 | 4.26 | 0.03 |
9α | 2.20 | 2.18 | -0.02 |
17 | 2.53 | 2.55 | 0.02 |
18 | 1.18 | 1.20 | 0.02 |
19 | 1.17 | 1.19 | 0.02 |
11 | 2.88 | 2.89 | 0.01 |
13 | 1.11 | 1.12 | 0.01 |
14 | 1.48 | 1.49 | 0.01 |
J | 3 | 4 | J(4) – J(3) |
---|---|---|---|
4,5β | 7.0 | 3.4 | -3.6 |
8,9α | 6.8 | 5.3 | -1.5 |
6,7 | 5.5 | 4.1 | -1.4 |
4,5α | 10.0 | 8.7 | -1.3 |
4,15a | 7.9 | 6.7 | -1.2 |
2,4 | 0.0 | 1.1 | 1.1 |
5α,6 | 8.6 | 9.7 | 1.1 |
7,11 | 8.3 | 9.3 | 1.0 |
5β,6 | 0.8 | 1.4 | 0.6 |
9α,9β | 15.0 | 15.5 | 0.5 |
8,9β | 2.5 | 3.0 | 0.5 |
7,8 | 9.3 | 9.8 | 0.5 |
17,18 | 7.2 | 6.8 | -0.4 |
5α,5β | 14.0 | 14.3 | 0.3 |
15a,15b | 10.7 | 10.5 | -0.2 |
4,15b | 5.9 | 5.8 | -0.1 |
11,13 | 7.4 | 7.5 | 0.1 |
3 | 4 | |
---|---|---|
C-1 | 205.5 | 205.9 |
C-2 | 105.9 | 102.8 |
C-3 | 189.0 | 189.0 |
C-4 | 42.5 | 39.6 |
C-5 | 35.2 | 34.5 |
C-6 | 79.5 | 78.1 |
C-7 | 51.9 | 49.8 |
C-8 | 70.4 | 71.1 |
C-9 | 40.4 | 37.4 |
C-10 | 89.3 | 88.2 |
C-11 | 38.4 | 37.3 |
C-12 | 177.7 | 177.8 |
C-13 | 10.8 | 10.3 |
C-14 | 19.9 | 19.9 |
C-15 | 63.4 | 62.0 |
C-16 | 175.3 | 175.4 |
C-17 | 34.2 | 34.2 |
C-18 | 18.6 | 18.7 |
C-19 | 18.8 | 18.7 |
Irradiated Hydrogen | Enhanced Signals | |
---|---|---|
Compound 3 | Compound 4 | |
5α | 5β, 7, 15, 6 | 5β, 4, 7, 6 (small) |
(+9α+9β in 3) | (8, through 9α and 9β) | |
5β | 5α, 4, 15, 6 | 5α, 6, 15 (small) |
(+9α+9β in 4) | (8, through 9α and 9β) | |
6 | 5α, 5β, 13, 7 | 5β, 13 (small) |
7 | 11, 5α [8, 6 small] | 11, 5α |
13 | 11, 8, 6 | 8, 11, 6 (small) |
(+18+19) | (17, through 18 and 19) | (17, through 18 and 19) |
11 | 7, 13 | 7, 13 |
4 | Not effected | 15, 5α |
Experimental
General
Preparation of Compound 2
Preparation of Compound 3
Preparation of Compound 4
Compound | % lysis | |||
100 | 250 | 500 μg / mL | ||
Negative control | 0.0 | 0.0 | 0.0 | |
Goyazensolide (1) | 9.9 | 12.9 | 22.4 | |
Phthalimide derivative (2) | 50.0 | 52.9 | 61.5 | |
*positive control gentian violet 250 μg / mL |
Acknowledgements
References and Notes
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Da Silva, G.V.J.; Heleno, V.C.G.; Constantino, M.G. Reduction and Preparation of a Phthalimide Derivative from a Furo-heliangolide. Molecules 2000, 5, 908-915. https://doi.org/10.3390/50600908
Da Silva GVJ, Heleno VCG, Constantino MG. Reduction and Preparation of a Phthalimide Derivative from a Furo-heliangolide. Molecules. 2000; 5(6):908-915. https://doi.org/10.3390/50600908
Chicago/Turabian StyleDa Silva, Gil Valdo José, Vladimir Constantino Gomes Heleno, and Mauricio Gomes Constantino. 2000. "Reduction and Preparation of a Phthalimide Derivative from a Furo-heliangolide" Molecules 5, no. 6: 908-915. https://doi.org/10.3390/50600908