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Int. J. Mol. Sci. 2010, 11(11), 4407-4416; doi:10.3390/ijms11114407

Involvement of Glutamate Transporter-1 in Neuroprotection against Global Brain Ischemia-Reperfusion Injury Induced by Postconditioning in Rats

1
Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
2
Department of Neurosurgery, YuYao People’s Hospital, Zhejiang Province, 315400, China
*
Author to whom correspondence should be addressed.
Received: 17 September 2010 / Revised: 1 October 2010 / Accepted: 22 October 2010 / Published: 3 November 2010
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Ischemic postconditioning refers to several transient reperfusion and ischemia cycles after an ischemic event and before a long duration of reperfusion. The procedure produces neuroprotective effects. The mechanisms underlying these neuroprotective effects are poorly understood. In this study, we found that most neurons in the CA1 region died after 10 minutes of ischemia and is followed by 72 hours of reperfusion. However, brain ischemic postconditioning (six cycles of 10 s/10 s reperfusion/re-occlusion) significantly reduced neuronal death. Significant up-regulation of Glutamate transporter-1 was found after 3, 6, 24, 72 hours of reperfusion. The present study showed that ischemic postconditioning decreases cell death and that upregulation of GLT-1 expression may play an important role on this effect. View Full-Text
Keywords: ischemic postconditioning; brain ischemia reperfusion injury; neuroprotection; glutamate transporter 1(GLT-1) ischemic postconditioning; brain ischemia reperfusion injury; neuroprotection; glutamate transporter 1(GLT-1)
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zhang, W.; Miao, Y.; Zhou, S.; Wang, B.; Luo, Q.; Qiu, Y. Involvement of Glutamate Transporter-1 in Neuroprotection against Global Brain Ischemia-Reperfusion Injury Induced by Postconditioning in Rats. Int. J. Mol. Sci. 2010, 11, 4407-4416.

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