Next Article in Journal
Combined Pharmacophore Modeling, Docking, and 3D-QSAR Studies of PLK1 Inhibitors
Next Article in Special Issue
RNA Aptamer Evolution: Two Decades of SELEction
Previous Article in Journal / Special Issue
A Concise Review on Epigenetic Regulation: Insight into Molecular Mechanisms
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2011, 12(12), 8695-8712; doi:10.3390/ijms12128695

Genetic Association and Altered Gene Expression of Mir-155 in Multiple Sclerosis Patients

Dipartimento di Biologia e Genetica per le Scienze Mediche, Università degli Studi di Milano, Milano, Italia/Via Viotti 3/5, Milan 20133, Italy
Hemostasis & Thrombosis Center, Hematology Section and Department Biomedical Sciences & Advanced Therapies, University of Ferrara, Ferrara, Italy/Corso Giovecca 203, Ferrara 44121, Italy
Department of Neurological, Neuropsychological, Morphological and Movement Sciences, Policlinico G. Rossi, University of Verona, Verona, Italy/Piazzale L.A. Scuro 10,Verona 37134, Italy
Department of Medical Sciences, University of Eastern Piedmont, Novara, Italy/Via Solaroli, 17, Novara 28100, Italy
Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Eastern Piedmont, Novara, Italy/Via Solaroli, 17, Novara 28100, Italy
Department of Neurology, A.O.U. Maggiore della Carità, Novara, Italy/Corso Mazzini 18, Novara 28100, Italy
Author to whom correspondence should be addressed.
Received: 19 September 2011 / Revised: 31 October 2011 / Accepted: 22 November 2011 / Published: 1 December 2011
(This article belongs to the Special Issue Non-Coding RNAs)
View Full-Text   |   Download PDF [423 KB, uploaded 19 June 2014]   |  


Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system characterized by chronic inflammation, demyelination, and axonal damage. As microRNA (miRNA)-dependent alterations in gene expression in hematopoietic cells are critical for mounting an appropriate immune response, miRNA deregulation may result in defects in immune tolerance. In this frame, we sought to explore the possible involvement of miRNAs in MS pathogenesis by monitoring the differential expression of 22 immunity-related miRNAs in peripheral blood mononuclear cells of MS patients and healthy controls, by using a microbead-based technology. Three miRNAs resulted >2 folds up-regulated in MS vs controls, whereas none resulted down-regulated. Interestingly, the most up-regulated miRNA (mir-155; fold change = 3.30; P = 0.013) was previously reported to be up-regulated also in MS brain lesions. Mir-155 up-regulation was confirmed by qPCR experiments. The role of mir-155 in MS susceptibility was also investigated by genotyping four single nucleotide polymorphisms (SNPs) mapping in the mir-155 genomic region. A haplotype of three SNPs, corresponding to a 12-kb region encompassing the last exon of BIC (the B-cell Integration Cluster non-coding RNA, from which mir-155 is processed), resulted associated with the disease status (P = 0.035; OR = 1.36, 95% CI = 1.05–1.77), suggesting that this locus strongly deserves further investigations. View Full-Text
Keywords: multiple sclerosis; miRNA; expression profile; mir-155; association analysis multiple sclerosis; miRNA; expression profile; mir-155; association analysis

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Paraboschi, E.M.; Soldà, G.; Gemmati, D.; Orioli, E.; Zeri, G.; Benedetti, M.D.; Salviati, A.; Barizzone, N.; Leone, M.; Duga, S.; Asselta, R. Genetic Association and Altered Gene Expression of Mir-155 in Multiple Sclerosis Patients. Int. J. Mol. Sci. 2011, 12, 8695-8712.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top