Effect of β-Cyclodextrin Complexation on Solubility and Enzymatic Conversion of Naringin
AbstractIn the present paper, the effect of β-cyclodextrin (β-CD) inclusion complexation on the solubility and enzymatic hydrolysis of naringin was investigated. The inclusion complex of naringin/β-CD at the molar ratio of 1:1 was obtained by the dropping method and was characterized by differential scanning calorimetry. The solubility of naringin complexes in water at 37 ± 0.1 °C was 15 times greater than that of free naringin. Snailase-involved hydrolysis conditions were tested for the bioconversion of naringin into naringenin using the univariate experimental design. Naringin can be transformed into naringenin by snailase-involved hydrolysis. The optimum conditions for enzymatic hydrolysis were determined as follows: pH 5.0, temperature 37 °C, ratio of snailase/substrate 0.8, substrate concentration 20 mg·mL−1, and reaction time 12 h. Under the optimum conditions, the transforming rate of naringenin from naringin for inclusion complexes and free naringin was 98.7% and 56.2% respectively, suggesting that β-CD complexation can improve the aqueous solubility and consequently the enzymatic hydrolysis rate of naringin. View Full-Text
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Cui, L.; Zhang, Z.-H.; Sun, E.; Jia, X.-B. Effect of β-Cyclodextrin Complexation on Solubility and Enzymatic Conversion of Naringin. Int. J. Mol. Sci. 2012, 13, 14251-14261.
Cui L, Zhang Z-H, Sun E, Jia X-B. Effect of β-Cyclodextrin Complexation on Solubility and Enzymatic Conversion of Naringin. International Journal of Molecular Sciences. 2012; 13(11):14251-14261.Chicago/Turabian Style
Cui, Li; Zhang, Zhen-Hai; Sun, E; Jia, Xiao-Bin. 2012. "Effect of β-Cyclodextrin Complexation on Solubility and Enzymatic Conversion of Naringin." Int. J. Mol. Sci. 13, no. 11: 14251-14261.