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Int. J. Mol. Sci. 2012, 13(11), 14845-14864; doi:10.3390/ijms131114845

The Role of Vascular Endothelial Growth Factor A Polymorphisms in Breast Cancer

Division of Head-Neck and Breast Surgery, Department of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
* Author to whom correspondence should be addressed.
Received: 18 September 2012 / Revised: 16 October 2012 / Accepted: 1 November 2012 / Published: 13 November 2012
(This article belongs to the Special Issue Advances in Molecular Oncology (special issue))
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Breast cancer is the most common cancer in females and the leading cause of cancer death in women worldwide. Angiogenesis, the formation of new blood vessels, plays an important role in the development and progression of breast cancer. Vascular endothelial growth factor A (VEGFA), the key modulator of angiogenesis, is highly expressed in cancer tissue and correlates with its more aggressive features. Polymorphisms of VEGFA alter the levels of expression and subsequently influence the susceptibility and aggressiveness of breast cancer. Assessment of VEGFA polymorphisms may be used for the identification of patients suitable for anti-VEGFA therapy.
Keywords: angiogenesis; breast cancer; polymorphism; vascular endothelial growth factor angiogenesis; breast cancer; polymorphism; vascular endothelial growth factor
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sa-nguanraksa, D.; O-charoenrat, P. The Role of Vascular Endothelial Growth Factor A Polymorphisms in Breast Cancer. Int. J. Mol. Sci. 2012, 13, 14845-14864.

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