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Int. J. Mol. Sci. 2012, 13(11), 14973-14991; doi:10.3390/ijms131114973

Healing, Antioxidant and Cytoprotective Properties of Indigofera truxillensis in Different Models of Gastric Ulcer in Rats

1,2,* , 3
1 Department of Biological Sciences, Federal University of Goiás, 75704-020, Catalão, Goiás, Brazil 2 Department of Structural and Functional Biology, Biology Institute, Campinas University, 13083-865, Campinas, São Paulo, Brazil 3 Department of Pharmacology, Faculty of Medical Sciences, University of Campinas, 13083-887, Campinas, São Paulo, Brazil 4 Department of Organic Chemistry, Institute of Chemistry, São Paulo State University, 14800-900, Araraquara, São Paulo, Brazil 5 Department of Physiology, Institute of Biosciences, São Paulo State University, 18618-000, Botucatu, São Paulo, Brazil
* Author to whom correspondence should be addressed.
Received: 28 June 2012 / Revised: 27 August 2012 / Accepted: 8 October 2012 / Published: 15 November 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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The present study evaluated the antiulcerogenic activity and mechanisms of the aqueous (AqF 100 mg/kg) and ethyl acetate (AcF 50 mg/kg) fractions from Indigofera truxillensis leaves. This dose was selected to assess its activity on ulcer healing and its action on gastric acid and mucus secretion, prostaglandin production and antioxidant enzyme activity (superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione reductase (GSH-Rd)). Gastric ulcer was induced by absolute ethanol. Antisecretory action, mucus and prostaglandin production, healing and antioxidant enzyme activities were evaluated for both fractions. AqF and AcF significantly inhibited the gastric mucosal damage caused by ethanol. This effect was statistically significant at 100 and 50 mg/kg compared with the vehicle. Neither fraction interfered with gastric secretion. AcF increased the PGE2 production, and both fractions increased mucus production. l-NAME did not alter the gastroprotection exerted by the fractions, but N-ethylmaleimide attenuated only AcF. In the ischemia/reperfusion model both fractions inhibited the mucosal damage. AcF increased SOD, GSH-Px and GSH-Rd activity, but AqF increased only SOD and GSH-Px. In the acetic acid-induced ulcer model AcF only accelerated ulcer healing. These results showed that Indigofera truxillensis acted as a gastroprotective agent, stimulating protective factors and antioxidants enzymes.
Keywords:  Indigofera truxillensis; gastric ulcer; medicinal plants; antioxidant enzymes  ; Indigofera truxillensis; gastric ulcer; medicinal plants; antioxidant enzymes
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Luiz-Ferreira, A.; Cola, M.; Barbastefano, V.; de-Faria, F.M.; Almeida, A.B.A.; Farias-Silva, E.; Calvo, T.R.; Hiruma-Lima, C.A.; Vilegas, W.; Souza-Brito, A.R.M. Healing, Antioxidant and Cytoprotective Properties of Indigofera truxillensis in Different Models of Gastric Ulcer in Rats. Int. J. Mol. Sci. 2012, 13, 14973-14991.

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